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B4GALNT4 beta-1,4-N-acetyl-galactosaminyltransferase 4 [ Homo sapiens (human) ]

Gene ID: 338707, updated on 23-Nov-2021

Summary

Official Symbol
B4GALNT4provided by HGNC
Official Full Name
beta-1,4-N-acetyl-galactosaminyltransferase 4provided by HGNC
Primary source
HGNC:HGNC:26315
See related
Ensembl:ENSG00000182272 MIM:618560
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 7.9), ovary (RPKM 4.2) and 5 other tissues See more
Orthologs
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Genomic context

See B4GALNT4 in Genome Data Viewer
Location:
11p15.5
Exon count:
21
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (369499..382117)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (369499..382117)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376505 Neighboring gene CRISPRi-validated cis-regulatory element chr11.30 Neighboring gene plakophilin 3 Neighboring gene single Ig and TIR domain containing

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of beta-1,4-N-acetyl-galactosaminyl transferase 4 (B4GALNT4) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ25045

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1
Names
N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase
NGalNAc-T1
beta-1,4-N-acetyl-galactosaminyl transferase 4
beta-1,4-N-acetylgalactosaminyltransferase IV
beta1,4-N-acetylgalactosaminyltransferases IV
beta4GalNAc-T4
beta4GalNAcT4
betaGT4
NP_848632.2
XP_016873143.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178537.5NP_848632.2  N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1

    See identical proteins and their annotated locations for NP_848632.2

    Status: VALIDATED

    Source sequence(s)
    AB089939, AC138230, BF058197, CN348077
    Consensus CDS
    CCDS7694.1
    UniProtKB/Swiss-Prot
    Q76KP1
    Related
    ENSP00000328277.6, ENST00000329962.11
    Conserved Domains (2) summary
    cl08459
    Location:142263
    PA14; PA14 domain
    cl11394
    Location:7111020
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    369499..382117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017654.1XP_016873143.1  N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1 isoform X1

RNA

  1. XR_001747858.1 RNA Sequence

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