Kr-h1 Kruppel homolog 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Kr-h1provided by FlyBase
Official Full Name: Kruppel homolog 1provided by FlyBase
Primary source: FLYBASE:FBgn0266450
Locus tag: Dmel_CG45074
See related: AllianceGenome:FB:FBgn0266450
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 44/11; CG18783; CG45074; CG9167; Dmel\CG45074; Kr h; Kr-h; kr-h1; Kr-H1; l(2)05208; l(2)10642; P381; Pow
Old locus tag: Dmel_CG18783
Summary: Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of compound eye photoreceptor development; negative regulation of neuron projection development; and response to ecdysone. Located in cytosol and nucleus. Is expressed in several structures, including dorsal ectoderm; embryonic/larval digestive system; embryonic/larval nervous system; extended germ band embryo; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 2. Orthologous to several human genes including ZBTB24 (zinc finger and BTB domain containing 24); ZBTB48 (zinc finger and BTB domain containing 48); and ZNF358 (zinc finger protein 358). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 26B5-26B5; 2-18 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (6082603..6096498)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (6082603..6096498)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Juvenile hormone signal transducer hairy inhibits Kruppel homolog1 expression.
Title: Juvenile hormone signal transducer hairy inhibits Krüppel homolog1 expression.
Fat body-derived juvenile hormone acid methyltransferase functions to maintain iron homeostasis in Drosophila melanogaster.
Title: Fat body-derived juvenile hormone acid methyltransferase functions to maintain iron homeostasis in Drosophila melanogaster.
Juvenile hormone inhibits adult cuticle formation in Drosophila melanogaster through Kr-h1/Dnmt2-mediated DNA methylation of Acp65A promoter.
Title: Juvenile hormone inhibits adult cuticle formation in Drosophila melanogaster through Kr-h1/Dnmt2-mediated DNA methylation of Acp65A promoter.
MicroRNA miR-927 targets the juvenile hormone primary response gene Kruppel homolog1 to control Drosophila developmental growth.
Title: MicroRNA miR-927 targets the juvenile hormone primary response gene Krüppel homolog1 to control Drosophila developmental growth.
Kr-h1 represses ecdysone biosynthesis by directly inhibiting the transcription of steroidogenic enzymes in both Drosophila and Bombyx.
Title: Krüppel homolog 1 represses insect ecdysone biosynthesis by directly inhibiting the transcription of steroidogenic enzymes.
During photoreceptor differentiation, transient repression of Kr-h1 represents a key step regulating neuronal maturation.
Title: Orthodenticle and Kruppel homolog 1 regulate Drosophila photoreceptor maturation.
KR-H1 has a potential for modulating neuronal morphogenesis, it appears physiologically involved in coordinating general ecdysone signaling.
Title: Roles of Drosophila Kruppel-homolog 1 in neuronal morphogenesis.
At the chromosomal level, KR-H localisation is dynamic and that the protein is recruited to, and released from, loci harbouring an important subset of the known regulatory genes as the response advances.
Title: Dynamic localisation of KR-H during an ecdysone response in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0696 (e-PCR)
- UniSTS:80277

Dm0374 (e-PCR)
- UniSTS:41453

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in metamorphosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of compound eye photoreceptor development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to ecdysone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: kruppel homolog 1

Names: CG45074-PA; CG45074-PB; Kr-h1-PA; Kr-h1-PB; Krueppel-homolog alpha-isoform; Kruppel-homolog 1; Kruppel-homolog-1; krupple homolog 1; passion of white

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

6082603..6096498

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058119.5 → NP_477467.1 kruppel homolog 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477467.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08155

Related

FBpp0310809

Conserved Domains (4) summary

COG5048
Location:216 → 366

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:219 → 239

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:387 → 409

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:259 → 284

zf-H2C2_2; Zinc-finger double domain
NM_058118.5 → NP_477466.1 kruppel homolog 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477466.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08155, Q9VMH5

Related

FBpp0310810

Conserved Domains (4) summary

COG5048
Location:270 → 420

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:273 → 293

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:441 → 463

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:313 → 338

zf-H2C2_2; Zinc-finger double domain