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HSPB2 heat shock protein family B (small) member 2 [ Homo sapiens (human) ]

Gene ID: 3316, updated on 5-Aug-2018

Summary

Official Symbol
HSPB2provided by HGNC
Official Full Name
heat shock protein family B (small) member 2provided by HGNC
Primary source
HGNC:HGNC:5247
See related
Ensembl:ENSG00000170276 MIM:602179; Vega:OTTHUMG00000166886
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MKBP; HSP27; Hs.78846; LOH11CR1K
Summary
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The protein is expressed preferentially in the heart and skeletal muscle. This protein regulates Myotonic Dystrophy Protein Kinase, which plays an important role in maintenance of muscle structure and function. [provided by RefSeq, Dec 2012]
Expression
Biased expression in heart (RPKM 45.3), fat (RPKM 26.7) and 13 other tissues See more
Orthologs

Genomic context

See HSPB2 in Genome Data Viewer
Location:
11q23.1
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (111912736..111914093)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (111783460..111784817)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ferredoxin-fold anticodon binding domain containing 1 Neighboring gene chromosome 11 open reading frame 1 Neighboring gene ribosomal protein L37a pseudogene 8 Neighboring gene HSPB2-C11orf52 readthrough (NMD candidate) Neighboring gene crystallin alpha B Neighboring gene chromosome 11 open reading frame 52 Neighboring gene RNA, 5S ribosomal pseudogene 351 Neighboring gene DIX domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
    Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
  • Epstein-Barr virus infection, conserved biosystem (from KEGG)
    Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
  • IL-1 signaling pathway, organism-specific biosystem (from WikiPathways)
    IL-1 signaling pathway, organism-specific biosystemThe IL-1 family of cytokines currently consists of 11 members which are encoded by distinct genes and includes IL-1?, IL-1?, and the IL-1 Receptor antagonist (IL-1RA). The major role of IL-1 type cyt...
  • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough HSPB2-C11orf52

Readthrough gene: HSPB2-C11orf52, Included gene: C11orf52

Homology

Clone Names

  • MGC133245

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme activator activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
response to unfolded protein NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
heat shock protein beta-2
Names
DMPK-binding protein
heat shock 27kDa protein 2
heat-shock protein beta-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033080.1 RefSeqGene

    Range
    5001..6358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001541.3NP_001532.1  heat shock protein beta-2

    See identical proteins and their annotated locations for NP_001532.1

    Status: REVIEWED

    Source sequence(s)
    AB096250, AI131288
    Consensus CDS
    CCDS8352.1
    UniProtKB/Swiss-Prot
    Q16082
    UniProtKB/TrEMBL
    A8KAH6
    Related
    ENSP00000302476.3, OTTHUMP00000234293, ENST00000304298.3, OTTHUMT00000391669
    Conserved Domains (1) summary
    cl00175
    Location:67148
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    111912736..111914093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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