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Hspb2 heat shock protein 2 [ Mus musculus (house mouse) ]

Gene ID: 69253, updated on 8-May-2024

Summary

Official Symbol
Hspb2provided by MGI
Official Full Name
heat shock protein 2provided by MGI
Primary source
MGI:MGI:1916503
See related
Ensembl:ENSMUSG00000038086 AllianceGenome:MGI:1916503
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MKBP; 27kDa; HSP27; 2810021G24Rik
Summary
Predicted to be a structural constituent of eye lens. Acts upstream of or within somatic muscle development. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including adrenal gland; cardiovascular system; gut; limb segment; and skeletal musculature. Orthologous to human HSPB2 (heat shock protein family B (small) member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 66.3), lung adult (RPKM 22.9) and 11 other tissues See more
Orthologs
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Genomic context

Location:
9 A5.3; 9 27.75 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (50662372..50663654, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (50751072..50752354, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene DIX domain containing 1 Neighboring gene predicted gene, 39337 Neighboring gene predicted gene, 51674 Neighboring gene STARR-seq mESC enhancer starr_24116 Neighboring gene STARR-seq mESC enhancer starr_24117 Neighboring gene RIKEN cDNA 2310030G06 gene Neighboring gene STARR-seq mESC enhancer starr_24121 Neighboring gene crystallin, alpha B Neighboring gene STARR-positive B cell enhancer ABC_E3828 Neighboring gene cilia and flagella associated protein 68 Neighboring gene ferredoxin-fold anticodon binding domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of eye lens IEA
Inferred from Electronic Annotation
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to heat IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within somatic muscle development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
heat shock protein beta-2
Names
heat shock 27kD protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164708.1NP_001158180.1  heat shock protein beta-2 isoform 2

    See identical proteins and their annotated locations for NP_001158180.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site, compared to variant 1. The resulting protein (isoform 2) is missing an internal segment when it is compared to isoform 1.
    Source sequence(s)
    AK012780, BU704695
    Consensus CDS
    CCDS90564.1
    UniProtKB/Swiss-Prot
    Q99PR8
    Related
    ENSMUSP00000148970.2, ENSMUST00000217159.2
    Conserved Domains (1) summary
    cl00175
    Location:3254
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.
  2. NM_024441.3NP_077761.3  heat shock protein beta-2 isoform 1

    See identical proteins and their annotated locations for NP_077761.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AK012780, BC064051, BU704695
    Consensus CDS
    CCDS23171.1
    UniProtKB/Swiss-Prot
    E9QKE3, Q99PR8, Q9CZC2
    UniProtKB/TrEMBL
    Q6P3C8
    Related
    ENSMUSP00000042374.4, ENSMUST00000042790.5
    Conserved Domains (1) summary
    cl00175
    Location:67148
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    50662372..50663654 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)