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HSPA8 heat shock protein family A (Hsp70) member 8 [ Homo sapiens (human) ]

Gene ID: 3312, updated on 17-Jun-2024

Summary

Official Symbol
HSPA8provided by HGNC
Official Full Name
heat shock protein family A (Hsp70) member 8provided by HGNC
Primary source
HGNC:HGNC:5241
See related
Ensembl:ENSG00000109971 MIM:600816; AllianceGenome:HGNC:5241
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAP1; HSC54; HSC70; HSC71; HSP71; HSP73; LAP-1; NIP71; HEL-33; HSPA10; HEL-S-72p
Summary
This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in brain (RPKM 443.0), kidney (RPKM 352.5) and 25 other tissues See more
Orthologs
NEW
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Genomic context

See HSPA8 in Genome Data Viewer
Location:
11q24.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (123057489..123062462, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (123086071..123093285, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (122928197..122932844, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S26 pseudogene 43 Neighboring gene ribosomal protein L31 pseudogene 47 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4011 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5676 Neighboring gene uncharacterized LOC124902775 Neighboring gene small nucleolar RNA, C/D box 14E Neighboring gene small nucleolar RNA, C/D box 14D Neighboring gene small nucleolar RNA, C/D box 14C Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4012 Neighboring gene Sharpr-MPRA regulatory region 9139 Neighboring gene CXADR like membrane protein Neighboring gene ReSE screen-validated silencer GRCh37_chr11:123005125-123005345 Neighboring gene FUN14 domain-containing protein 1-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heat shock 70kDa protein 8 (HSPA8, HSC70), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
env Over expression of hsp70 with a herpes viral amplicon vector protects cultured hippocampal rat neurons from gp120 neurotoxicity PubMed
env The exposure of permissive CD4+ cells to HIV-1 gp120 increases the synthesis and nuclear translocation of 70kDa heat shock protein PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heat shock 70kDa protein 8 (HSPA8, HSC70), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify heat shock 70kDa protein 8 (HSPA8, HSC70), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
nef Heat shock proteins Hsp40 and Hsp70 interact with HIV-1 Nef and form a complex in cells PubMed
nef HIV-1 Nef increases the production of exosomes and co-localizes with exosomal proteins CD63, AIP/Alix, AChE, Hsc70, LAMP2, and annexin A2 in HeLa cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify heat shock 70kDa protein 8 (HSPA8, HSC70), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
gag Hsc70 is specifically incorporated into HIV-1 virions, similar to Hsp70 which is incorporated into virions through an interaction with HIV-1 Gag PubMed
Tat tat Heat shock 70kDa protein 8 (HSPA8) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
tat Hsp70 and Hsp90 and Cdc37 regulate the stabilization and folding of CDK9 as well as the assembly of an active CDK9/cyclin T1 complex responsible for P-TEFb-mediated HIV-1 Tat transactivation PubMed
Vif vif HIV-1 Vif interacts with HSPA8; predicted interaction to be relevant to gene regulation PubMed
Vpr vpr HIV-1 Vpr is required for the inhibitory effect of Hsp70 on viral gene expression and replication PubMed
vpr HIV-1 Vpr competes with Hsp70 for binding to karyopherin alpha PubMed
matrix gag Hsp70 facilitates nuclear import of HIV-1 preintegration complexes by stimulating the binding of HIV-1 Matrix to karyopherin alpha PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC29929, MGC131511

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables A1 adenosine receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables ADP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP hydrolysis activity NAS
Non-traceable Author Statement
more info
PubMed 
enables ATP hydrolysis activity TAS
Traceable Author Statement
more info
 
enables ATP-dependent protein disaggregase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables C3HC4-type RING finger domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables G protein-coupled receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables MHC class II protein complex binding HDA PubMed 
enables RNA binding HDA PubMed 
enables cadherin binding HDA PubMed 
enables clathrin-uncoating ATPase activity IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables peptide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylserine binding IEA
Inferred from Electronic Annotation
more info
 
enables prostaglandin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein carrier chaperone TAS
Traceable Author Statement
more info
PubMed 
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-macromolecule adaptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables unfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in ATP metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to cadmium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to heat IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to starvation TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to steroid hormone stimulus TAS
Traceable Author Statement
more info
 
involved_in cerebellum development IEA
Inferred from Electronic Annotation
more info
 
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chaperone-mediated autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in chaperone-mediated autophagy TAS
Traceable Author Statement
more info
PubMed 
involved_in chaperone-mediated autophagy translocation complex disassembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in clathrin coat disassembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in clathrin coat disassembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in estrous cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in forebrain development IEA
Inferred from Electronic Annotation
more info
 
involved_in kidney development IEA
Inferred from Electronic Annotation
more info
 
involved_in late endosomal microautophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome NAS
Non-traceable Author Statement
more info
PubMed 
involved_in maintenance of postsynaptic specialization structure IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane organization TAS
Traceable Author Statement
more info
 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of NLRP3 inflammasome complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of supramolecular fiber organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation by host of viral genome replication IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of T cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of lysosomal membrane permeability IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of phagocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein refolding IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in protein folding NAS
Non-traceable Author Statement
more info
PubMed 
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein refolding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein targeting to lysosome involved in chaperone-mediated autophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein targeting to lysosome involved in chaperone-mediated autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein targeting to lysosome involved in chaperone-mediated autophagy TAS
Traceable Author Statement
more info
PubMed 
involved_in protein transmembrane import into intracellular organelle IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of postsynapse organization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein complex stability ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of protein import TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein-containing complex assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in response to activity IEA
Inferred from Electronic Annotation
more info
 
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to nickel cation IEA
Inferred from Electronic Annotation
more info
 
involved_in response to odorant IEA
Inferred from Electronic Annotation
more info
 
involved_in response to progesterone IEA
Inferred from Electronic Annotation
more info
 
involved_in response to unfolded protein NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
involved_in slow axonal transport IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic vesicle uncoating IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Prp19 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Prp19 complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in autophagosome IEA
Inferred from Electronic Annotation
more info
 
located_in blood microparticle HDA PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane TAS
Traceable Author Statement
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendritic shaft IEA
Inferred from Electronic Annotation
more info
 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space HDA PubMed 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
located_in focal adhesion HDA PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in glycinergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
 
located_in late endosome IEA
Inferred from Electronic Annotation
more info
 
located_in lumenal side of lysosomal membrane TAS
Traceable Author Statement
more info
PubMed 
located_in lysosomal lumen TAS
Traceable Author Statement
more info
PubMed 
located_in lysosomal matrix IEA
Inferred from Electronic Annotation
more info
 
is_active_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in photoreceptor inner segment IEA
Inferred from Electronic Annotation
more info
 
located_in photoreceptor ribbon synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
 
located_in presynaptic cytosol IEA
Inferred from Electronic Annotation
more info
 
part_of protein folding chaperone complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
 
part_of spliceosomal complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in terminal bouton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
heat shock cognate 71 kDa protein
Names
LPS-associated protein 1
N-myristoyltransferase inhibitor protein 71
constitutive heat shock protein 70
epididymis luminal protein 33
epididymis secretory sperm binding protein Li 72p
heat shock 70kDa protein 8
heat shock 70kd protein 10
heat shock cognate protein 54
heat shock protein family A member 8
lipopolysaccharide-associated protein 1
NP_006588.1
NP_694881.1
XP_011541100.1
XP_054224589.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029473.1 RefSeqGene

    Range
    5001..9648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006597.6NP_006588.1  heat shock cognate 71 kDa protein isoform 1

    See identical proteins and their annotated locations for NP_006588.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1).
    Source sequence(s)
    AK222628, AP000926, BC019816, DC395565
    Consensus CDS
    CCDS8440.1
    UniProtKB/Swiss-Prot
    P11142, Q9H3R6
    UniProtKB/TrEMBL
    Q53GZ6, V9HW22
    Related
    ENSP00000432083.1, ENST00000534624.6
    Conserved Domains (1) summary
    PTZ00009
    Location:1613
    PTZ00009; heat shock 70 kDa protein; Provisional
  2. NM_153201.4NP_694881.1  heat shock cognate 71 kDa protein isoform 2

    See identical proteins and their annotated locations for NP_694881.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses alternate splice sites, and is missing an exon in the 3' coding region compared to variant 1. However, it maintains the reading frame, and encodes a shorter isoform (2) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AB034951, AK222628, AP000926, DC395565
    Consensus CDS
    CCDS44754.1
    UniProtKB/TrEMBL
    Q53HF2
    Related
    ENSP00000404372.2, ENST00000453788.6
    Conserved Domains (1) summary
    PTZ00009
    Location:1462
    PTZ00009; heat shock 70 kDa protein; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    123057489..123062462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542798.2XP_011541100.1  heat shock cognate 71 kDa protein isoform X1

    See identical proteins and their annotated locations for XP_011541100.1

    UniProtKB/Swiss-Prot
    P11142, Q9H3R6
    UniProtKB/TrEMBL
    Q53GZ6, V9HW22
    Conserved Domains (1) summary
    PTZ00009
    Location:1613
    PTZ00009; heat shock 70 kDa protein; Provisional

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    123086071..123093285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368614.1XP_054224589.1  heat shock cognate 71 kDa protein isoform X1

    UniProtKB/Swiss-Prot
    P11142, Q9H3R6
    UniProtKB/TrEMBL
    Q53GZ6, V9HW22