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Hspa8 heat shock protein 8 [ Mus musculus (house mouse) ]

Gene ID: 15481, updated on 7-Apr-2019

Summary

Official Symbol
Hspa8provided by MGI
Official Full Name
heat shock protein 8provided by MGI
Primary source
MGI:MGI:105384
See related
Ensembl:ENSMUSG00000015656
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hsc70; Hsc71; Hsc73; Hsp73; Hspa10; 2410008N15Rik
Expression
Ubiquitous expression in placenta adult (RPKM 956.1), CNS E11.5 (RPKM 802.7) and 28 other tissues See more
Orthologs

Genomic context

See Hspa8 in Genome Data Viewer
Location:
9 A5.1; 9 21.55 cM
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (40801273..40805199)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (40609356..40613282)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 35371 Neighboring gene CXADR-like membrane protein Neighboring gene small nucleolar RNA, C/D box 14C Neighboring gene small nucleolar RNA, C/D box 14D Neighboring gene small nucleolar RNA, C/D box 14E Neighboring gene brain specific homeobox Neighboring gene junctional cadherin complex regulator Neighboring gene ubiquitin specific peptidase 10 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102007, MGC106514, MGC118485

Gene Ontology Provided by MGI

Function Evidence Code Pubs
A1 adenosine receptor binding ISO
Inferred from Sequence Orthology
more info
 
ADP binding ISO
Inferred from Sequence Orthology
more info
 
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding ISO
Inferred from Sequence Orthology
more info
 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity ISO
Inferred from Sequence Orthology
more info
 
ATPase activity, coupled IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity, coupled IDA
Inferred from Direct Assay
more info
PubMed 
ATPase activity, coupled ISO
Inferred from Sequence Orthology
more info
 
C3HC4-type RING finger domain binding ISO
Inferred from Sequence Orthology
more info
 
G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
RNA binding ISO
Inferred from Sequence Orthology
more info
 
chaperone binding ISO
Inferred from Sequence Orthology
more info
 
clathrin-uncoating ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
clathrin-uncoating ATPase activity ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
peptide binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylserine binding IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding involved in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding, bridging ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
unfolded protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
ATP metabolic process ISO
Inferred from Sequence Orthology
more info
 
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
axo-dendritic transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular protein complex disassembly ISO
Inferred from Sequence Orthology
more info
 
cellular response to heat IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to unfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone cofactor-dependent protein refolding IGI
Inferred from Genetic Interaction
more info
PubMed 
chaperone-mediated autophagy ISO
Inferred from Sequence Orthology
more info
 
chaperone-mediated autophagy translocation complex disassembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone-mediated autophagy translocation complex disassembly ISO
Inferred from Sequence Orthology
more info
 
chaperone-mediated protein folding EXP
Inferred from Experiment
more info
PubMed 
chaperone-mediated protein folding IDA
Inferred from Direct Assay
more info
PubMed 
chaperone-mediated protein folding ISO
Inferred from Sequence Orthology
more info
 
chaperone-mediated protein transport involved in chaperone-mediated autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone-mediated protein transport involved in chaperone-mediated autophagy ISO
Inferred from Sequence Orthology
more info
 
clathrin coat disassembly IGI
Inferred from Genetic Interaction
more info
PubMed 
clathrin coat disassembly ISO
Inferred from Sequence Orthology
more info
 
late endosomal microautophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
late endosomal microautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
maintenance of postsynaptic specialization structure ISO
Inferred from Sequence Orthology
more info
 
modulation by host of viral process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of supramolecular fiber organization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation by host of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lysosomal membrane permeability ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein refolding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein folding IDA
Inferred from Direct Assay
more info
PubMed 
protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein refolding ISO
Inferred from Sequence Orthology
more info
 
protein targeting to lysosome involved in chaperone-mediated autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein targeting to lysosome involved in chaperone-mediated autophagy ISO
Inferred from Sequence Orthology
more info
 
regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
regulation of postsynapse organization EXP
Inferred from Experiment
more info
PubMed 
regulation of postsynapse organization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein complex stability ISO
Inferred from Sequence Orthology
more info
 
regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
response to unfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
slow axonal transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Prp19 complex ISO
Inferred from Sequence Orthology
more info
 
asymmetric synapse ISO
Inferred from Sequence Orthology
more info
 
autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome ISO
Inferred from Sequence Orthology
more info
 
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
chaperone complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
 
dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
glycinergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glycinergic synapse ISO
Inferred from Sequence Orthology
more info
 
intermediate filament ISO
Inferred from Sequence Orthology
more info
 
late endosome IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal matrix ISO
Inferred from Sequence Orthology
more info
 
lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosome ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
messenger ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 
microtubule ISO
Inferred from Sequence Orthology
more info
 
myelin sheath HDA PubMed 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuron spine ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perikaryon ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
photoreceptor inner segment ISO
Inferred from Sequence Orthology
more info
 
photoreceptor ribbon synapse IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynapse ISO
Inferred from Sequence Orthology
more info
 
postsynaptic cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic cytosol ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
PubMed 
presynapse EXP
Inferred from Experiment
more info
PubMed 
presynapse IDA
Inferred from Direct Assay
more info
PubMed 
presynapse ISO
Inferred from Sequence Orthology
more info
 
presynaptic cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
presynaptic cytosol ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 
spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
terminal bouton ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
heat shock cognate 71 kDa protein
Names
heat shock 70 kDa protein 8
heat shock cognate hsc73
heat shock protein cognate 70

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364480.1NP_001351409.1  heat shock cognate 71 kDa protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158355
    Conserved Domains (1) summary
    cl26953
    Location:1594
    HSP70; Hsp70 protein
  2. NM_031165.5NP_112442.2  heat shock cognate 71 kDa protein isoform 1

    See identical proteins and their annotated locations for NP_112442.2

    Status: VALIDATED

    Source sequence(s)
    AK151775, CD774246
    Consensus CDS
    CCDS23083.1
    UniProtKB/Swiss-Prot
    P63017
    Related
    ENSMUSP00000015800.9, ENSMUST00000015800.15
    Conserved Domains (2) summary
    cd10233
    Location:6381
    HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
    PTZ00009
    Location:1613
    PTZ00009; heat shock 70 kDa protein; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

    Range
    40801273..40805199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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