HSPA1B heat shock protein family A (Hsp70) member 1B [Homo sapiens (human)] - Gene

Summary

Official Symbol: HSPA1Bprovided by HGNC
Official Full Name: heat shock protein family A (Hsp70) member 1Bprovided by HGNC
Primary source: HGNC:HGNC:5233
See related: Ensembl:ENSG00000204388 MIM:603012
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HSP72; HSPA1; HSX70; HSP70-1; HSP70-2; HSP70.1; HSP70.2; HSP70-1B
Summary: This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]
Orthologs: all

Genomic context

Location:: 6p21.33

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
109.20200228	current	GRCh38.p13 (GCF_000001405.39)	6	NC_000006.12 (31827738..31830254)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (31789964..31798032)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that phosphorylation of HSP72 heat-shock protein (Hsp72) on threonine Thr(66) by during mitosis promotes its localization to the spindle by stabilizing its interactions with components of the mitotic spindle.
Title: Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release.
HSPA1A and HSPA1B, are major orchestrators of the cellular stress response and are associated with several human diseases. The phylogenetic analyses revealed that the duplication of HSPA1A and HSPA1B originated in a lineage proceeding to placental mammals, and henceforth they remained in conserved synteny.
Title: Concurrent action of purifying selection and gene conversion results in extreme conservation of the major stress-inducible Hsp70 genes in mammals.
Data show that HSPA1B exerts a positive effect on hepatocellular carcinoma (HCC) cell growth and may be involved in the HBV-miR- 340- 5p- ATF7 axis.
Title: Hepatitis B virus-regulated growth of liver cancer cells occurs through the microRNA-340-5p-activating transcription factor 7-heat shock protein A member 1B axis.
the presence of HSPA1B 1267GG genotype significantly increases the risk of glaucoma in northern Iran
Title: [The GG genotype of the HSPA1B gene is associated with increased risk of glaucoma in northern Iran].
Downregulation of HSPA1b impaired mesenchymal stem cell osteogenic and chondrogenic differentiation.
Title: Downregulation of Heat Shock Protein 70 Impairs Osteogenic and Chondrogenic Differentiation in Human Mesenchymal Stem Cells.
Heat shock protein 70-2 (HSP70-2) expression was detected in 78 % of colorectal cancer (CRC) patients.
Title: Heat shock protein 70-2 (HSP70-2) is a novel therapeutic target for colorectal cancer and is associated with tumor growth.
The rs2763979 locus of the HSP70 genes may be associated with susceptibility to noise-induced hearing loss (NIHL) in Chinese individuals, and other HSP70 genes may also be susceptibility genes for NIHL, but the results must be further replicated in additional independent sample sets.
Title: Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study.
HSPA1B was down-regulated in atrial fibrillation subjects who suffered a stroke.
Title: Hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis without increased bleeding risk.
The 1267HSP70-2 polymorphism is associated with obesity in an Iranian population, supporting a possible potential genetic link between obesity and cardiovascular diseases.
Title: Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity.
Polymorphism of HSP70 A1B gene is associated with the development of esophageal Carcinoma.
Title: Polymorphisms in Heat Shock Proteins A1B and A1L (HOM) as Risk Factors for Oesophageal Carcinoma in Northeast India.

Submit: New GeneRIF Correction See all GeneRIFs (87)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Tandem affinity purification and mass spectrometry analysis identify heat shock 70kDa protein 1B (HSPA1B), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
	env	Over expression of hsp70 with a herpes viral amplicon vector protects cultured hippocampal rat neurons from gp120 neurotoxicity	PubMed
	env	The exposure of permissive CD4+ cells to HIV-1 gp120 increases the synthesis and nuclear translocation of 70kDa heat shock protein	PubMed
Gag-Pol	gag-pol	Tandem affinity purification and mass spectrometry analysis identify heat shock 70kDa protein 1B (HSPA1B), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Nef	nef	Tandem affinity purification and mass spectrometry analysis identify heat shock 70kDa protein 1B (HSPA1B), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
	nef	Heat shock proteins Hsp40 and Hsp70 interact with HIV-1 Nef and form a complex in cells	PubMed
	nef	HIV-1 Nef suppresses Hsp70-mediated HIV-1 Tat activation	PubMed
Pr55(Gag)	gag	Tandem affinity purification and mass spectrometry analysis identify heat shock 70kDa protein 1B (HSPA1B), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
	gag	Hsp70 co-sediments with HIV-1 capsid protein in sucrose density gradients, providing evidence that it is specifically incorporated into HIV-1 virions through an interaction with HIV-1 Gag proteins	PubMed
	gag	Hsp70 is incorporated into HIV-1 virions through an interaction with HIV-1 Gag	PubMed
Tat	tat	HIV-1 Nef suppresses Hsp70-mediated HIV-1 Tat activation	PubMed
	tat	Hsp70 and Hsp90 and Cdc37 regulate the stabilization and folding of CDK9 as well as the assembly of an active CDK9/cyclin T1 complex responsible for P-TEFb-mediated HIV-1 Tat transactivation	PubMed
Vpr	vpr	HIV-1 Vpr is required for the inhibitory effect of Hsp70 on viral gene expression and replication	PubMed
	vpr	HIV-1 Vpr competes with Hsp70 for binding to karyopherin alpha	PubMed
matrix	gag	Hsp70 facilitates nuclear import of HIV-1 preintegration complexes by stimulating the binding of HIV-1 Matrix to karyopherin alpha	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G30153 (e-PCR)
- UniSTS:17447

PMC314357P1 (e-PCR)
- UniSTS:272944

HSPA1B_126 (e-PCR)
- UniSTS:277331

GDB:204303 (e-PCR)
- UniSTS:156113

GDB:592864 (e-PCR)
- UniSTS:157927

PMC117401P1 (e-PCR)
- UniSTS:270334

Homology

Homologs of the HSPA1B gene: The HSPA1B gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, fruit fly, S.cerevisiae, K.lactis, E.gossypii, A.thaliana, and frog.
Orthologs from Annotation Pipeline: 13 organisms have orthologs with human gene HSPA1B
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
ATP binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
ATP binding	IDA Inferred from Direct Assay more info	PubMed
ATPase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
ATPase activity	IDA Inferred from Direct Assay more info	PubMed
ATPase activity	TAS Traceable Author Statement more info
C3HC4-type RING finger domain binding	IPI Inferred from Physical Interaction more info	PubMed
G protein-coupled receptor binding	IDA Inferred from Direct Assay more info	PubMed
RNA binding	HDA more info	PubMed
enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
heat shock protein binding	IPI Inferred from Physical Interaction more info	PubMed
histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
misfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein N-terminus binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding involved in protein folding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein binding involved in protein folding	IDA Inferred from Direct Assay more info	PubMed
signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
unfolded protein binding	IDA Inferred from Direct Assay more info	PubMed
unfolded protein binding	NAS Non-traceable Author Statement more info	PubMed
unfolded protein binding	TAS Traceable Author Statement more info	PubMed
virus receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
ATP metabolic process	IDA Inferred from Direct Assay more info	PubMed
cellular heat acclimation	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to heat	IDA Inferred from Direct Assay more info	PubMed
cellular response to oxidative stress	TAS Traceable Author Statement more info	PubMed
cellular response to unfolded protein	IBA Inferred from Biological aspect of Ancestor more info	PubMed
chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
mRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
negative regulation of cell death	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell death	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of inclusion body assembly	IDA Inferred from Direct Assay more info	PubMed
negative regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
neutrophil degranulation	TAS Traceable Author Statement more info
positive regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of interleukin-8 production	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of microtubule nucleation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of tumor necrosis factor-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
protein refolding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein refolding	IDA Inferred from Direct Assay more info	PubMed
protein refolding	IMP Inferred from Mutant Phenotype more info	PubMed
protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
protein stabilization	TAS Traceable Author Statement more info	PubMed
NOT regulation of cell death	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cellular response to heat	TAS Traceable Author Statement more info
regulation of mitotic spindle assembly	IBA Inferred from Biological aspect of Ancestor more info	PubMed
regulation of mitotic spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
response to unfolded protein	IBA Inferred from Biological aspect of Ancestor more info	PubMed
vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
viral entry into host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
colocalizes_with COP9 signalosome	IBA Inferred from Biological aspect of Ancestor more info	PubMed
aggresome	IDA Inferred from Direct Assay more info	PubMed
blood microparticle	HDA more info	PubMed
centriole	IDA Inferred from Direct Assay more info	PubMed
centrosome	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	TAS Traceable Author Statement more info	PubMed
cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cytosol	IDA Inferred from Direct Assay more info	PubMed
cytosol	TAS Traceable Author Statement more info
endoplasmic reticulum	TAS Traceable Author Statement more info	PubMed
extracellular exosome	HDA more info	PubMed
extracellular region	TAS Traceable Author Statement more info
ficolin-1-rich granule lumen	TAS Traceable Author Statement more info
focal adhesion	HDA more info	PubMed
inclusion body	IDA Inferred from Direct Assay more info	PubMed
mitochondrion	TAS Traceable Author Statement more info	PubMed
nuclear speck	IDA Inferred from Direct Assay more info	PubMed
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein-containing complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
vesicle	HDA more info	PubMed

General protein information

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Preferred Names: heat shock 70 kDa protein 1B

Names: HSP70-1/HSP70-2; HSP70.1/HSP70.2; Heat shock 70 kDa protein 1; Heat shock 70 kDa protein 1A; heat shock 70 kDa protein 1/2; heat shock 70 kDa protein 1A/1B; heat shock 70 kDa protein 2; heat shock 70kD protein 1B; heat shock 70kDa protein 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.