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ZAR1 zygote arrest 1 [ Homo sapiens (human) ]

Gene ID: 326340, updated on 3-Apr-2024

Summary

Official Symbol
ZAR1provided by HGNC
Official Full Name
zygote arrest 1provided by HGNC
Primary source
HGNC:HGNC:20436
See related
Ensembl:ENSG00000182223 MIM:607520; AllianceGenome:HGNC:20436
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Z3CXXC6
Summary
This maternal effect gene is oocyte-specific and encodes a protein that is thought to function in the initiation of embryogenesis. A similar protein in mouse is required for female fertility. [provided by RefSeq, Jul 2013]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See ZAR1 in Genome Data Viewer
Location:
4p11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (48490252..48497635)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (48457286..48465127)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (48492269..48496406)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene SLAIN motif family member 2 Neighboring gene U6 snRNA-associated Sm-like protein LSm2 Neighboring gene CRISPRi-validated cis-regulatory element chr4.1483 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15408 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15409 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:48491403-48491940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15411 Neighboring gene solute carrier family 10 member 4 Neighboring gene FRY like transcription coactivator Neighboring gene RNA, U5E small nuclear 3, pseudogene Neighboring gene Sharpr-MPRA regulatory region 3875 Neighboring gene Sharpr-MPRA regulatory region 7734 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15412 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15413 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15414 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:48832895-48833458 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:48833459-48834021 Neighboring gene OCIA domain containing 1 Neighboring gene OCIAD1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA sequestering activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables mRNA 3'-UTR binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular condensate scaffold activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in mRNA stabilization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in non-membrane-bounded organelle assembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in oocyte maturation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in cytoplasmic ribonucleoprotein granule IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular non-membrane-bounded organelle ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
zygote arrest protein 1
Names
oocyte-specific maternal effect factor
zinc finger, 3CxxC-type 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175619.3NP_783318.1  zygote arrest protein 1

    See identical proteins and their annotated locations for NP_783318.1

    Status: REVIEWED

    Source sequence(s)
    AC096952, AI217763, AY191416, BC136265
    Consensus CDS
    CCDS3483.1
    UniProtKB/Swiss-Prot
    Q86SH2
    UniProtKB/TrEMBL
    B9EG67
    Related
    ENSP00000329803.4, ENST00000327939.4
    Conserved Domains (1) summary
    pfam13695
    Location:325410
    zf-3CxxC; Zinc-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    48490252..48497635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_925129.4 RNA Sequence

  2. XR_007096396.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    48457286..48465127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349911.1XP_054205886.1  zygote arrest protein 1 isoform X1

  2. XM_054349912.1XP_054205887.1  zygote arrest protein 1 isoform X1