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Zar1 zygote arrest 1 [ Mus musculus (house mouse) ]

Gene ID: 317755, updated on 5-Jan-2023

Summary

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Official Symbol
Zar1provided by MGI
Official Full Name
zygote arrest 1provided by MGI
Primary source
MGI:MGI:2180337
See related
Ensembl:ENSMUSG00000063935 AllianceGenome:MGI:2180337
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable mRNA binding activity involved in posttranscriptional gene silencing. Predicted to be involved in translation. Located in cytoplasm. Is expressed in early conceptus; ovary; and rib. Orthologous to human ZAR1 (zygote arrest 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward ovary adult (RPKM 33.1) See more
Orthologs
human all
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Genomic context

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See Zar1 in Genome Data Viewer
Location:
5; 5 C3.2
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (72734456..72738707, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (72577113..72581361, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene nuclear transcription factor, X-box binding-like 1 Neighboring gene predicted gene, 34144 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), pseudogene Neighboring gene cyclic nucleotide gated channel alpha 1 Neighboring gene predicted gene 5297

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genome transfer for the prevention of female infertility caused by maternal gene mutation. Bai D, et al. J Genet Genomics, 2020 Jun 20. PMID 32893179
  2. Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment. Cheng S, et al. Science, 2022 Oct 21. PMID 36264786
  3. Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for the oocyte-to-embryo transition. Wu X, et al. Nat Genet, 2003 Feb. PMID 12539046
  4. Cis-acting elements (E-box and NBE) in the promoter region of three maternal genes (Histone H1oo, Nucleoplasmin 2, and Zygote Arrest 1) are required for oocyte-specific gene expression in the mouse. Tsunemoto K, et al. Mol Reprod Dev, 2008 Jul. PMID 18324673
  5. Quantification of oocyte-specific transcripts in follicle-enclosed oocytes during antral development and maturation in vitro. Sánchez F, et al. Mol Hum Reprod, 2009 Sep. PMID 19553355

See all (21) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genome transfer for the prevention of female infertility caused by maternal gene mutation.
    Title: Genome transfer for the prevention of female infertility caused by maternal gene mutation.
  2. A previously unrecognized role of ZAR1/2 in regulating the maternal transcriptome and translational activation in maturing oocytes.
    Title: ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.
  3. The highest Zar1 mRNA levels were detected in oocytes in the pre-antral follicle stage.
    Title: Quantification of oocyte-specific transcripts in follicle-enclosed oocytes during antral development and maturation in vitro.
  4. Promoter activities of three mouse maternal genes (H1oo, Npm2, and Zar1) in oocytes and pre-implantation embryos, and examined the promoters and to obttain the best promoter for oocytte gene expression.
    Title: Cis-acting elements (E-box and NBE) in the promoter region of three maternal genes (Histone H1oo, Nucleoplasmin 2, and Zygote Arrest 1) are required for oocyte-specific gene expression in the mouse.
  5. The carboxyl-termini of these ZAR1 proteins contain an important functional domain that is conserved through vertebrate evolution and that may be necessary for normal female reproduction in the transition from oocyte to embryonic life.
    Title: Zygote arrest 1 (Zar1) is an evolutionarily conserved gene expressed in vertebrate ovaries.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC123986, MGC123987

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA sequestering activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular condensate scaffold activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in non-membrane-bounded organelle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oocyte maturation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in intracellular non-membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zygote arrest protein 1
Names
oocyte-specific maternal effect factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174877.3 → NP_777366.1  zygote arrest protein 1

    See identical proteins and their annotated locations for NP_777366.1

    Status: VALIDATED

    Source sequence(s)
    BC099399, DV647930
    Consensus CDS
    CCDS19331.1
    UniProtKB/Swiss-Prot
    Q4FZK8, Q80SU3
    Related
    ENSMUSP00000073221.3, ENSMUST00000073528.4
    Conserved Domains (1) summary
    pfam13695
    Location:262 → 347
    zf-3CxxC; Zinc-binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    72734456..72738707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503990.5 → XP_006504053.1  zygote arrest protein 1 isoform X1

    Conserved Domains (1) summary
    PRK07764
    Location:160 → 263
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80SU3.1 GenPept UniProtKB/Swiss-Prot:Q80SU3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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