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Islr2 immunoglobulin superfamily containing leucine-rich repeat 2 [ Mus musculus (house mouse) ]

Gene ID: 320563, updated on 26-Sep-2022

Summary

Official Symbol
Islr2provided by MGI
Official Full Name
immunoglobulin superfamily containing leucine-rich repeat 2provided by MGI
Primary source
MGI:MGI:2444277
See related
Ensembl:ENSMUSG00000051243 AllianceGenome:MGI:2444277
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Linx; Mbu-3; mKIAA1465; B930052A04Rik
Summary
Involved in positive regulation of axon extension. Located in cell surface. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Orthologous to human ISLR2 (immunoglobulin superfamily containing leucine rich repeat 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 62.5), CNS E14 (RPKM 61.4) and 5 other tissues See more
Orthologs
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Genomic context

See Islr2 in Genome Data Viewer
Location:
9; 9 B
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (58103580..58113563, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (58196297..58204319, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily containing leucine-rich repeat Neighboring gene predicted gene, 39344 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene microRNA 6385 Neighboring gene promyelocytic leukemia Neighboring gene stomatin-like 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of axon extension IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
immunoglobulin superfamily containing leucine-rich repeat protein 2
Names
leucine-rich repeat domain and immunoglobulin domain containing axon extension protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161535.1NP_001155007.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    BC096531
    Consensus CDS
    CCDS52812.1
    UniProtKB/Swiss-Prot
    Q5RKR3
    UniProtKB/TrEMBL
    E9Q9N7
    Related
    ENSMUSP00000130879.2, ENSMUST00000163200.3
    Conserved Domains (5) summary
    smart00082
    Location:225273
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:8096
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:144183
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:164227
    LRR_8; Leucine rich repeat
    pfam13895
    Location:288417
    Ig_2; Immunoglobulin domain
  2. NM_001161536.1NP_001155008.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform b precursor

    See identical proteins and their annotated locations for NP_001155008.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 2-8 encode the same isoform.
    Source sequence(s)
    BC096531, CA325040, CA328406
    Consensus CDS
    CCDS23238.1
    UniProtKB/Swiss-Prot
    Q5RKR3, Q6ZPQ3
    Related
    ENSMUSP00000130322.2, ENSMUST00000163897.8
    Conserved Domains (6) summary
    TIGR00864
    Location:154228
    PCC; polycystin cation channel protein
    sd00033
    Location:3652
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99159
    LRR_8; Leucine rich repeat
    pfam13927
    Location:232360
    Ig_3; Immunoglobulin domain
    cd00096
    Location:256263
    Ig; Ig strand B [structural motif]
    cl11960
    Location:351373
    Ig; Immunoglobulin domain
  3. NM_001161537.1NP_001155009.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform b precursor

    See identical proteins and their annotated locations for NP_001155009.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 2-8 encode the same isoform.
    Source sequence(s)
    BC096531, CB526596
    Consensus CDS
    CCDS23238.1
    UniProtKB/Swiss-Prot
    Q5RKR3, Q6ZPQ3
    Conserved Domains (6) summary
    TIGR00864
    Location:154228
    PCC; polycystin cation channel protein
    sd00033
    Location:3652
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99159
    LRR_8; Leucine rich repeat
    pfam13927
    Location:232360
    Ig_3; Immunoglobulin domain
    cd00096
    Location:256263
    Ig; Ig strand B [structural motif]
    cl11960
    Location:351373
    Ig; Immunoglobulin domain
  4. NM_001161538.1NP_001155010.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform b precursor

    See identical proteins and their annotated locations for NP_001155010.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 2-8 encode the same isoform.
    Source sequence(s)
    BC096531, CA750352
    Consensus CDS
    CCDS23238.1
    UniProtKB/Swiss-Prot
    Q5RKR3, Q6ZPQ3
    Related
    ENSMUSP00000127228.2, ENSMUST00000170421.8
    Conserved Domains (6) summary
    TIGR00864
    Location:154228
    PCC; polycystin cation channel protein
    sd00033
    Location:3652
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99159
    LRR_8; Leucine rich repeat
    pfam13927
    Location:232360
    Ig_3; Immunoglobulin domain
    cd00096
    Location:256263
    Ig; Ig strand B [structural motif]
    cl11960
    Location:351373
    Ig; Immunoglobulin domain
  5. NM_001161539.1NP_001155011.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform b precursor

    See identical proteins and their annotated locations for NP_001155011.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 2-8 encode the same isoform.
    Source sequence(s)
    BC096531, CD350184
    Consensus CDS
    CCDS23238.1
    UniProtKB/Swiss-Prot
    Q5RKR3, Q6ZPQ3
    Conserved Domains (6) summary
    TIGR00864
    Location:154228
    PCC; polycystin cation channel protein
    sd00033
    Location:3652
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99159
    LRR_8; Leucine rich repeat
    pfam13927
    Location:232360
    Ig_3; Immunoglobulin domain
    cd00096
    Location:256263
    Ig; Ig strand B [structural motif]
    cl11960
    Location:351373
    Ig; Immunoglobulin domain
  6. NM_001161540.1NP_001155012.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform b precursor

    See identical proteins and their annotated locations for NP_001155012.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 2-8 encode the same isoform.
    Source sequence(s)
    BC096531, BQ443868, BY111208
    Consensus CDS
    CCDS23238.1
    UniProtKB/Swiss-Prot
    Q5RKR3, Q6ZPQ3
    Related
    ENSMUSP00000129328.2, ENSMUST00000165276.2
    Conserved Domains (6) summary
    TIGR00864
    Location:154228
    PCC; polycystin cation channel protein
    sd00033
    Location:3652
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99159
    LRR_8; Leucine rich repeat
    pfam13927
    Location:232360
    Ig_3; Immunoglobulin domain
    cd00096
    Location:256263
    Ig; Ig strand B [structural motif]
    cl11960
    Location:351373
    Ig; Immunoglobulin domain
  7. NM_001161541.1NP_001155013.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform b precursor

    See identical proteins and their annotated locations for NP_001155013.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 2-8 encode the same isoform.
    Source sequence(s)
    BB611833, BC096531
    Consensus CDS
    CCDS23238.1
    UniProtKB/Swiss-Prot
    Q5RKR3, Q6ZPQ3
    Related
    ENSMUSP00000109781.3, ENSMUST00000114144.9
    Conserved Domains (6) summary
    TIGR00864
    Location:154228
    PCC; polycystin cation channel protein
    sd00033
    Location:3652
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99159
    LRR_8; Leucine rich repeat
    pfam13927
    Location:232360
    Ig_3; Immunoglobulin domain
    cd00096
    Location:256263
    Ig; Ig strand B [structural motif]
    cl11960
    Location:351373
    Ig; Immunoglobulin domain
  8. NM_177193.5NP_796167.2  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform b precursor

    See identical proteins and their annotated locations for NP_796167.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 2-8 encode the same isoform.
    Source sequence(s)
    BC059068, BY079125, CA328406
    Consensus CDS
    CCDS23238.1
    UniProtKB/Swiss-Prot
    Q5RKR3, Q6ZPQ3
    Related
    ENSMUSP00000149095.2, ENSMUST00000215950.2
    Conserved Domains (6) summary
    TIGR00864
    Location:154228
    PCC; polycystin cation channel protein
    sd00033
    Location:3652
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99159
    LRR_8; Leucine rich repeat
    pfam13927
    Location:232360
    Ig_3; Immunoglobulin domain
    cd00096
    Location:256263
    Ig; Ig strand B [structural motif]
    cl11960
    Location:351373
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    58103580..58113563 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155062.1XP_036010955.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZPQ3
    Conserved Domains (6) summary
    TIGR00864
    Location:154228
    PCC; polycystin cation channel protein
    sd00033
    Location:3652
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99159
    LRR_8; Leucine rich repeat
    pfam13927
    Location:232360
    Ig_3; Immunoglobulin domain
    cd00096
    Location:256263
    Ig; Ig strand B [structural motif]
    cl11960
    Location:351373
    Ig; Immunoglobulin domain
  2. XM_036155064.1XP_036010957.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZPQ3
    Conserved Domains (6) summary
    TIGR00864
    Location:154228
    PCC; polycystin cation channel protein
    sd00033
    Location:3652
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99159
    LRR_8; Leucine rich repeat
    pfam13927
    Location:232360
    Ig_3; Immunoglobulin domain
    cd00096
    Location:256263
    Ig; Ig strand B [structural motif]
    cl11960
    Location:351373
    Ig; Immunoglobulin domain
  3. XM_036155061.1XP_036010954.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZPQ3
    Conserved Domains (6) summary
    TIGR00864
    Location:154228
    PCC; polycystin cation channel protein
    sd00033
    Location:3652
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99159
    LRR_8; Leucine rich repeat
    pfam13927
    Location:232360
    Ig_3; Immunoglobulin domain
    cd00096
    Location:256263
    Ig; Ig strand B [structural motif]
    cl11960
    Location:351373
    Ig; Immunoglobulin domain
  4. XM_030244418.2XP_030100278.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZPQ3
    Conserved Domains (6) summary
    TIGR00864
    Location:154228
    PCC; polycystin cation channel protein
    sd00033
    Location:3652
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99159
    LRR_8; Leucine rich repeat
    pfam13927
    Location:232360
    Ig_3; Immunoglobulin domain
    cd00096
    Location:256263
    Ig; Ig strand B [structural motif]
    cl11960
    Location:351373
    Ig; Immunoglobulin domain
  5. XM_006511230.3XP_006511293.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006511293.1

    UniProtKB/Swiss-Prot
    Q5RKR3, Q6ZPQ3
    Conserved Domains (6) summary
    TIGR00864
    Location:154228
    PCC; polycystin cation channel protein
    sd00033
    Location:3652
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99159
    LRR_8; Leucine rich repeat
    pfam13927
    Location:232360
    Ig_3; Immunoglobulin domain
    cd00096
    Location:256263
    Ig; Ig strand B [structural motif]
    cl11960
    Location:351373
    Ig; Immunoglobulin domain
  6. XM_036155065.1XP_036010958.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZPQ3
    Conserved Domains (6) summary
    TIGR00864
    Location:154228
    PCC; polycystin cation channel protein
    sd00033
    Location:3652
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99159
    LRR_8; Leucine rich repeat
    pfam13927
    Location:232360
    Ig_3; Immunoglobulin domain
    cd00096
    Location:256263
    Ig; Ig strand B [structural motif]
    cl11960
    Location:351373
    Ig; Immunoglobulin domain
  7. XM_006511229.4XP_006511292.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006511292.1

    UniProtKB/Swiss-Prot
    Q5RKR3, Q6ZPQ3
    Conserved Domains (6) summary
    TIGR00864
    Location:154228
    PCC; polycystin cation channel protein
    sd00033
    Location:3652
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99159
    LRR_8; Leucine rich repeat
    pfam13927
    Location:232360
    Ig_3; Immunoglobulin domain
    cd00096
    Location:256263
    Ig; Ig strand B [structural motif]
    cl11960
    Location:351373
    Ig; Immunoglobulin domain
  8. XM_006511232.4XP_006511295.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006511295.1

    UniProtKB/Swiss-Prot
    Q5RKR3, Q6ZPQ3
    Conserved Domains (6) summary
    TIGR00864
    Location:154228
    PCC; polycystin cation channel protein
    sd00033
    Location:3652
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99159
    LRR_8; Leucine rich repeat
    pfam13927
    Location:232360
    Ig_3; Immunoglobulin domain
    cd00096
    Location:256263
    Ig; Ig strand B [structural motif]
    cl11960
    Location:351373
    Ig; Immunoglobulin domain
  9. XM_030244417.1XP_030100277.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZPQ3
    Conserved Domains (6) summary
    TIGR00864
    Location:154228
    PCC; polycystin cation channel protein
    sd00033
    Location:3652
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99159
    LRR_8; Leucine rich repeat
    pfam13927
    Location:232360
    Ig_3; Immunoglobulin domain
    cd00096
    Location:256263
    Ig; Ig strand B [structural motif]
    cl11960
    Location:351373
    Ig; Immunoglobulin domain
  10. XM_006511231.5XP_006511294.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006511294.1

    UniProtKB/Swiss-Prot
    Q5RKR3, Q6ZPQ3
    Conserved Domains (6) summary
    TIGR00864
    Location:154228
    PCC; polycystin cation channel protein
    sd00033
    Location:3652
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99159
    LRR_8; Leucine rich repeat
    pfam13927
    Location:232360
    Ig_3; Immunoglobulin domain
    cd00096
    Location:256263
    Ig; Ig strand B [structural motif]
    cl11960
    Location:351373
    Ig; Immunoglobulin domain
  11. XM_006511234.5XP_006511297.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006511297.1

    UniProtKB/Swiss-Prot
    Q5RKR3, Q6ZPQ3
    Conserved Domains (6) summary
    TIGR00864
    Location:154228
    PCC; polycystin cation channel protein
    sd00033
    Location:3652
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99159
    LRR_8; Leucine rich repeat
    pfam13927
    Location:232360
    Ig_3; Immunoglobulin domain
    cd00096
    Location:256263
    Ig; Ig strand B [structural motif]
    cl11960
    Location:351373
    Ig; Immunoglobulin domain
  12. XM_030244419.2XP_030100279.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZPQ3
    Conserved Domains (6) summary
    TIGR00864
    Location:154228
    PCC; polycystin cation channel protein
    sd00033
    Location:3652
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99159
    LRR_8; Leucine rich repeat
    pfam13927
    Location:232360
    Ig_3; Immunoglobulin domain
    cd00096
    Location:256263
    Ig; Ig strand B [structural motif]
    cl11960
    Location:351373
    Ig; Immunoglobulin domain
  13. XM_036155063.1XP_036010956.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZPQ3
    Conserved Domains (6) summary
    TIGR00864
    Location:154228
    PCC; polycystin cation channel protein
    sd00033
    Location:3652
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99159
    LRR_8; Leucine rich repeat
    pfam13927
    Location:232360
    Ig_3; Immunoglobulin domain
    cd00096
    Location:256263
    Ig; Ig strand B [structural motif]
    cl11960
    Location:351373
    Ig; Immunoglobulin domain