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Fndc7 fibronectin type III domain containing 7 [ Mus musculus (house mouse) ]

Gene ID: 320181, updated on 17-Aug-2024

Summary

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Official Symbol
Fndc7provided by MGI
Official Full Name
fibronectin type III domain containing 7provided by MGI
Primary source
MGI:MGI:2443535
See related
Ensembl:ENSMUSG00000045326 AllianceGenome:MGI:2443535
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E230011A21Rik
Summary
Predicted to be located in extracellular region. Is expressed in adrenal gland; genitourinary system; gut; thymus; and trachea. Orthologous to human FNDC7 (fibronectin type III domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 10.0), genital fat pad adult (RPKM 1.3) and 2 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F3; 3 47.84 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (108760898..108797324, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (108853678..108890008, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene AKNA domain containing 1 Neighboring gene syntaxin binding protein 3 Neighboring gene STARR-positive B cell enhancer mm9_chr3:108642483-108642783 Neighboring gene STARR-positive B cell enhancer mm9_chr3:108643371-108643672 Neighboring gene STARR-positive B cell enhancer ABC_E3460 Neighboring gene STARR-positive B cell enhancer ABC_E4576 Neighboring gene PRP38 pre-mRNA processing factor 38 (yeast) domain containing B Neighboring gene HEN1 methyltransferase homolog 1 (Arabidopsis) Neighboring gene EEIG family member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

General gene information

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Homology

Clone Names

  • MGC132926

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fibronectin type III domain-containing protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165965.1 → NP_001159437.1  fibronectin type III domain-containing protein 7 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001159437.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AK054241, AK160805, AL671894, BC111898, BG069833
    Consensus CDS
    CCDS51050.1
    UniProtKB/TrEMBL
    J3QMB8
    Related
    ENSMUSP00000051172.5, ENSMUST00000053065.8
    Conserved Domains (3) summary
    smart00060
    Location:115 → 188
    FN3; Fibronectin type 3 domain
    cd00063
    Location:289 → 369
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:28 → 96
    fn3; Fibronectin type III domain

  2. NM_177091.5 → NP_796065.2  fibronectin type III domain-containing protein 7 isoform 1 precursor

    See identical proteins and their annotated locations for NP_796065.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK053989, AK054241, AK160805, AL671894, BG069833
    Consensus CDS
    CCDS17769.1
    UniProtKB/Swiss-Prot
    A2AED1, A2AED2, A2AED3, Q14DI4, Q14DS1, Q3TNR1, Q8BW61, Q8BW83
    UniProtKB/TrEMBL
    J3QMB8
    Related
    ENSMUSP00000099680.4, ENSMUST00000102620.10
    Conserved Domains (3) summary
    smart00060
    Location:115 → 188
    FN3; Fibronectin type 3 domain
    cd00063
    Location:375 → 455
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:28 → 96
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    108760898..108797324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163132.1 → XP_036019025.1  fibronectin type III domain-containing protein 7 isoform X1

    UniProtKB/TrEMBL
    J3QMB8
    Conserved Domains (3) summary
    smart00060
    Location:115 → 188
    FN3; Fibronectin type 3 domain
    cd00063
    Location:375 → 455
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:28 → 96
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. XM_011240139.2 → XP_011238441.1  fibronectin type III domain-containing protein 7 isoform X2

    UniProtKB/TrEMBL
    J3QMB8
    Conserved Domains (3) summary
    smart00060
    Location:115 → 188
    FN3; Fibronectin type 3 domain
    cd00063
    Location:375 → 455
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:28 → 96
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AED3.1 GenPept UniProtKB/Swiss-Prot:A2AED3

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