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Togaram2 TOG array regulator of axonemal microtubules 2 [ Mus musculus (house mouse) ]

Gene ID: 320159, updated on 2-Nov-2024

Summary

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Official Symbol
Togaram2provided by MGI
Official Full Name
TOG array regulator of axonemal microtubules 2provided by MGI
Primary source
MGI:MGI:2443498
See related
Ensembl:ENSMUSG00000045761 AllianceGenome:MGI:2443498
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam179a; 4632412N22Rik
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be located in microtubule cytoskeleton. Predicted to be active in cilium and cytoplasmic microtubule. Orthologous to human TOGARAM2 (TOG array regulator of axonemal microtubules 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in lung adult (RPKM 5.5), ovary adult (RPKM 3.3) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Togaram2 in Genome Data Viewer
Location:
17 E1.3; 17 42.06 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (71980153..72036666)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (71673156..71729671)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 43 Neighboring gene small nucleolar RNA, C/D box 53 Neighboring gene predicted gene, 22858 Neighboring gene STARR-positive B cell enhancer ABC_E10969 Neighboring gene photoreceptor cilium actin regulator Neighboring gene STARR-seq mESC enhancer starr_43179 Neighboring gene CAP-GLY domain containing linker protein family, member 4 Neighboring gene predicted gene, 30140

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
  2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of supramolecular fiber organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TOG array regulator of axonemal microtubules protein 2
Names
crescerin-2
family with sequence similarity 179, member A
protein FAM179A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177087.4 → NP_796061.2  TOG array regulator of axonemal microtubules protein 2

    See identical proteins and their annotated locations for NP_796061.2

    Status: VALIDATED

    Source sequence(s)
    AK158647, BB868766
    Consensus CDS
    CCDS28961.2
    UniProtKB/Swiss-Prot
    Q3TYG6, Q8C7B2
    UniProtKB/TrEMBL
    F6YU21
    Related
    ENSMUSP00000094886.4, ENSMUST00000097284.10
    Conserved Domains (1) summary
    pfam12348
    Location:496 → 679
    CLASP_N; CLASP N terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    71980153..72036666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160646.1 → XP_036016539.1  TOG array regulator of axonemal microtubules protein 2 isoform X5

    UniProtKB/TrEMBL
    F6YU21
    Conserved Domains (2) summary
    PHA03247
    Location:24 → 315
    PHA03247; large tegument protein UL36; Provisional
    pfam12348
    Location:496 → 672
    CLASP_N; CLASP N terminal

  2. XM_006524399.5 → XP_006524462.1  TOG array regulator of axonemal microtubules protein 2 isoform X4

    See identical proteins and their annotated locations for XP_006524462.1

    UniProtKB/TrEMBL
    F6YU21
    Conserved Domains (2) summary
    PHA03247
    Location:24 → 315
    PHA03247; large tegument protein UL36; Provisional
    pfam12348
    Location:496 → 672
    CLASP_N; CLASP N terminal

  3. XM_006524396.4 → XP_006524459.2  TOG array regulator of axonemal microtubules protein 2 isoform X1

    UniProtKB/TrEMBL
    F6YU21
    Conserved Domains (2) summary
    PHA03247
    Location:16 → 398
    PHA03247; large tegument protein UL36; Provisional
    pfam12348
    Location:579 → 755
    CLASP_N; CLASP N terminal

  4. XM_006524406.5 → XP_006524469.1  TOG array regulator of axonemal microtubules protein 2 isoform X6

    UniProtKB/TrEMBL
    F6YU21
    Conserved Domains (1) summary
    pfam12348
    Location:420 → 596
    CLASP_N; CLASP N terminal

  5. XM_006524397.5 → XP_006524460.2  TOG array regulator of axonemal microtubules protein 2 isoform X2

    UniProtKB/TrEMBL
    F6YU21
    Conserved Domains (2) summary
    PHA03247
    Location:16 → 398
    PHA03247; large tegument protein UL36; Provisional
    pfam12348
    Location:579 → 755
    CLASP_N; CLASP N terminal

  6. XM_006524403.5 → XP_006524466.1  TOG array regulator of axonemal microtubules protein 2 isoform X4

    See identical proteins and their annotated locations for XP_006524466.1

    UniProtKB/TrEMBL
    F6YU21
    Conserved Domains (2) summary
    PHA03247
    Location:24 → 315
    PHA03247; large tegument protein UL36; Provisional
    pfam12348
    Location:496 → 672
    CLASP_N; CLASP N terminal

  7. XM_006524398.5 → XP_006524461.1  TOG array regulator of axonemal microtubules protein 2 isoform X3

    UniProtKB/TrEMBL
    F6YU21
    Conserved Domains (2) summary
    PHA03247
    Location:83 → 374
    PHA03247; large tegument protein UL36; Provisional
    pfam12348
    Location:555 → 731
    CLASP_N; CLASP N terminal

  8. XM_006524400.5 → XP_006524463.1  TOG array regulator of axonemal microtubules protein 2 isoform X4

    See identical proteins and their annotated locations for XP_006524463.1

    UniProtKB/TrEMBL
    F6YU21
    Conserved Domains (2) summary
    PHA03247
    Location:24 → 315
    PHA03247; large tegument protein UL36; Provisional
    pfam12348
    Location:496 → 672
    CLASP_N; CLASP N terminal

  9. XM_006524402.5 → XP_006524465.1  TOG array regulator of axonemal microtubules protein 2 isoform X4

    See identical proteins and their annotated locations for XP_006524465.1

    UniProtKB/TrEMBL
    F6YU21
    Conserved Domains (2) summary
    PHA03247
    Location:24 → 315
    PHA03247; large tegument protein UL36; Provisional
    pfam12348
    Location:496 → 672
    CLASP_N; CLASP N terminal

  10. XM_006524401.4 → XP_006524464.1  TOG array regulator of axonemal microtubules protein 2 isoform X4

    See identical proteins and their annotated locations for XP_006524464.1

    UniProtKB/TrEMBL
    F6YU21
    Related
    ENSMUSP00000114359.2, ENSMUST00000144479.2
    Conserved Domains (2) summary
    PHA03247
    Location:24 → 315
    PHA03247; large tegument protein UL36; Provisional
    pfam12348
    Location:496 → 672
    CLASP_N; CLASP N terminal

  11. XM_036160647.1 → XP_036016540.1  TOG array regulator of axonemal microtubules protein 2 isoform X7

    Conserved Domains (1) summary
    pfam12348
    Location:136 → 312
    CLASP_N; CLASP N terminal

RNA

  1. XR_004939537.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TYG6.1 GenPept UniProtKB/Swiss-Prot:Q3TYG6

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