Conserved Protein Domain Family
CLASP_N
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pfam12348: CLASP_N (this model, PSSM-Id:289144 is obsolete and has been replaced by 432496)
CLASP N terminal
This region is found at the N terminal of CLIP-associated proteins (CLASPs). CLASPs are widely conserved microtubule plus-end-tracking proteins that regulate the stability of dynamic microtubules. In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present. In mammals, a second paralogue (CLASP2) exists which has some functional overlap with CLASP1.
Links
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Statistics
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PSSM-Id: 289144
Aligned: 56 rows
Threshold Bit Score: 168.914
Created: 27-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q2UCC9        339 VEDLFRVLSPAFEgRESEDNWRHREKYITSLRRLTYG-N-APHDFPQPFFTGIKTNLDGIFKAVNSLRTTLSTNGCLLIQ 416  Aspergillus o...
Q2H0S9          6 TDDQVANLIALL---RADVSIDTKVQQVTVVKSSIKQ-HmVPESCIVPVFEALH---LASSSQHALLVNAGFTALNHLFT 78   Chaetomium gl...
Q0D0S3         77 MDMKVDDLQAAL--TNPNLSIENKYDRLISVKSDIKQ-KnVPASLIPSLFDCLR---LAIAHNNIHIYTAGFATLSHLLK 150  Aspergillus t...
Q17AR9        308 MDEHMKSINTIV--GDKNMDWEKRVDALKKIRSLLMI-N---VQNSPTFTQQLKDLSIAFLDILKELRSQVIREACITLA 381  yellow fever ...
Q54VP9         58 LQKKLDDIVSEF--RNKDKEWTFRLKALQILQRIING-NgIEFKGWSSMLRSIS---PALIEQLTELRSTIVKEACASVS 131  Dictyostelium...
Q55BD8        409 FEYKMNEIIEIL--SNSDTEWSIKLNNILKFQAIIKS-GaCKLSNFIIVFNRIK---ELLALQILDKRSILMKEACLTLS 482  Dictyostelium...
Q6K6B1         78 LSREIERVASTL---HPDNEWAIRITAMQRVEGLVLG-G---AADYSAFPMLLKQLVTPLITQILDRRSSVVKQACHLLN 150  Japanese rice
XP_002146274    1 MEARATELLGTL--KNPNVSVDAKIAALTNVKSDIKQkN-VPEPAVLPLFESLRV---AISAQHSSLSSAGFSTLAHLLK 74   Talaromyces m...
XP_001776918  276 LAKEFEKAASMLA---PTQDWSIRMSAMRRIEGIVVG-G-ATK--YSGFLQLLKQLVNPLCDQLADRRSSIVKQACQLLK 348  Physcomitrell...
XP_002521154  221 LIREFEKVASTLV---PEKDWSIRIAAMQRIEGLVLG-G-AAD--YPCFRGLLKQLVSPLSTQLSDRRSSIVKQACHLLC 293  castor bean

Q2UCC9        417 DLAKIGGSR-IDPM-VEVIMQNLIKLCGGMKKISAQNGNVSVNDVLANVTyTPRL-LQHVTSACQDKNAQLRLFAAGWLK 493  Aspergillus o...
Q2H0S9         79 RLVRQDPRS-LTKE-GTRALPLIVEKLGDQKEKFRQLASQALATLYKVAP--VEVeRSVRNIAMVGKNARAKEASLHWLL 154  Chaetomium gl...
Q0D0S3        151 RLFIEELHTeVAAH-ARSLYPTLLERLGDHKERVRALAAQAFADLWKAAP--MDAeKHVLGTALVGRNPKAKEASLTWIL 227  Aspergillus t...
Q17AR9        382 YMSKLLKNR-LDQF-VIYILQELINLIQNSAKVISSAGIIALKYVIKHTH-APKIvPIITQNLMQSKSKDIRSTLCEIMI 458  yellow fever ...
Q54VP9        132 LLGFRMKSK-FEPF-ALQYTQALIRMVPVKTTIISESAHQTLKDILESVS-TKNLlQTFLDASLDQHNEQLRKRCSEYIY 208  Dictyostelium...
Q55BD8        483 LIAKELEHH-FEPY-LEKYFDVLLKCIVVTTKIVSESSDNCIKCIISSSK-SCKIiPRIYEAISSDKSVIIRSKCTEYLY 559  Dictyostelium...
Q6K6B1        151 FLSKELLRD-FEPC-AELLIPVLLKNVVITIHVIAESSDNCIKEMLRNCK-VARIlPKIIEFAKNDKSAVLRARCCEYAI 227  Japanese rice
XP_002146274   75 RLYIQENHH-LVLFhARQLYPICLERLGDHKERLRAQASQAFTDLWIAAP--QDVeAHVLGTALVGKNARAREMSMIWLA 151  Talaromyces m...
XP_001776918  349 VLTKELKSD-FDVF-AETFLPVLFKLVVITVLVIAESADACIKSMLQHCK-VARLlPKMVDFAKHDRSAVLRARCCEYLL 425  Physcomitrell...
XP_002521154  294 FLSKELLGD-FEGC-AEMFIPVLFKLVVITVLVIAESADNCIKTMLRNCK-VGRVlLRIADCAKNDRSAILRARCCEYAL 370  castor bean

Q2UCC9        494 TLLNKQS-HHKSSLEHGGGLa----lLEKSLKRGLTDANPGIREAMRGAFWTFHQMWPARGNNIL--SDLDNKTRHLLE 565  Aspergillus or...
Q2H0S9        155 QMHQEQG----------LQFr----aYVPTMMELLEDADGMVRDVAKSTVIELFRNAPGPAKSDLkkQLKNFKVRPAIE 219  Chaetomium glo...
Q0D0S3        228 SMHTSHD----------LLFr----pYVASLVACLEDADSAVRDTAKSTVVGLFNSAPAHAKADLqrEMAEQHVRKSIV 292  Aspergillus te...
Q17AR9        459 LLFDEWP---TKTLEKNSs------lLRDALRKGISDADSEARRHSRCAFWSFRRHFPDLADNLY--SSLDPATQRMME 526  yellow fever m...
Q54VP9        209 IVLSRAI--ENDGMILVSSVp----aLEKSIQKLLIDGASETRQMARYCFWAY-SELNEKSATLY---------STLIS 271  Dictyostelium ...
Q55BD8        560 ILLRDLPsSSGNHHHHHHLFekhldsIEKSIRIGVVDANLTARSYSRKVFIQFSLNWPDRSNSLF--STLDPSAQKTIE 636  Dictyostelium ...
Q6K6B1        228 LMLELWV--DTPEIQRSVd------lYEEFIKCCIEDATSEVRSSARACYRMFSRIWPERSHQLF--SSFESSRQKMIN 296  Japanese rice
XP_002146274  152 TMTR----------EHNILFr----sHVPSLVAALEDADSGVRDTAKTTIIEIFQNAPSRAKSDLkrQLSEHGVRKSIV 216  Talaromyces ma...
XP_001776918  426 LVLERWF--DAPEMQRSAe------lYEDLIKCCCADAMSEVRSLARQCYRVFARCWPDRARRLY--QAFDPVTQKVIN 494  Physcomitrella...
XP_002521154  371 LILEHWP--DAPEIQRSAd------lYEDMIRCCVADAMSEVRSTARMCYRMFAKTWPERSRRLF--SSFDPVIQRIIN 439  castor bean
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