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TOGARAM2 TOG array regulator of axonemal microtubules 2 [ Homo sapiens (human) ]

Gene ID: 165186, updated on 23-Nov-2021

Summary

Official Symbol
TOGARAM2provided by HGNC
Official Full Name
TOG array regulator of axonemal microtubules 2provided by HGNC
Primary source
HGNC:HGNC:33715
See related
Ensembl:ENSG00000189350
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM179A
Expression
Broad expression in lung (RPKM 1.7), spleen (RPKM 1.2) and 19 other tissues See more
Orthologs
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Genomic context

See TOGARAM2 in Genome Data Viewer
Location:
2p23.2
Exon count:
27
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (28981298..29052230)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (29204164..29275096)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene WD repeat domain 43 Neighboring gene small nucleolar RNA, C/D box 53B Neighboring gene small nucleolar RNA, C/D box 53 Neighboring gene photoreceptor cilium actin regulator Neighboring gene uncharacterized LOC105374386

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
GeneReviews: Not available
Genome-wide association study of recurrent early-onset major depressive disorder.
GeneReviews: Not available

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
TOG array regulator of axonemal microtubules protein 2
Names
crescerin-2
family with sequence similarity 179 member A
protein FAM179A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321538.3NP_001308467.1  TOG array regulator of axonemal microtubules protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC105398
    UniProtKB/TrEMBL
    B4DLF7
    Conserved Domains (1) summary
    pfam12348
    Location:448623
    CLASP_N; CLASP N terminal
  2. NM_001321539.3NP_001308468.1  TOG array regulator of axonemal microtubules protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC105398
    Conserved Domains (1) summary
    pfam12348
    Location:345487
    CLASP_N; CLASP N terminal
  3. NM_199280.4NP_954974.2  TOG array regulator of axonemal microtubules protein 2 isoform 1

    See identical proteins and their annotated locations for NP_954974.2

    Status: VALIDATED

    Source sequence(s)
    AC105398
    Consensus CDS
    CCDS1769.2
    UniProtKB/Swiss-Prot
    Q6ZUX3
    Related
    ENSP00000368876.3, ENST00000379558.5
    Conserved Domains (1) summary
    pfam12348
    Location:503678
    CLASP_N; CLASP N terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    28981298..29052230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532628.2XP_011530930.1  TOG array regulator of axonemal microtubules protein 2 isoform X4

    Conserved Domains (1) summary
    pfam12348
    Location:503671
    CLASP_N; CLASP N terminal
  2. XM_017003512.2XP_016859001.1  TOG array regulator of axonemal microtubules protein 2 isoform X7

  3. XM_017003507.1XP_016858996.1  TOG array regulator of axonemal microtubules protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZUX3
    Conserved Domains (1) summary
    pfam12348
    Location:503678
    CLASP_N; CLASP N terminal
  4. XM_017003508.1XP_016858997.1  TOG array regulator of axonemal microtubules protein 2 isoform X2

  5. XM_017003509.1XP_016858998.1  TOG array regulator of axonemal microtubules protein 2 isoform X3

  6. XM_011532631.1XP_011530933.1  TOG array regulator of axonemal microtubules protein 2 isoform X10

    See identical proteins and their annotated locations for XP_011530933.1

    UniProtKB/Swiss-Prot
    Q6ZUX3
    Related
    ENST00000465300.5
    Conserved Domains (1) summary
    pfam12348
    Location:30205
    CLASP_N; CLASP N terminal
  7. XM_017003511.1XP_016859000.1  TOG array regulator of axonemal microtubules protein 2 isoform X6

  8. XM_017003516.1XP_016859005.1  TOG array regulator of axonemal microtubules protein 2 isoform X11

  9. XM_017003510.1XP_016858999.1  TOG array regulator of axonemal microtubules protein 2 isoform X5

  10. XM_017003514.1XP_016859003.1  TOG array regulator of axonemal microtubules protein 2 isoform X9

  11. XM_017003515.2XP_016859004.1  TOG array regulator of axonemal microtubules protein 2 isoform X10

    UniProtKB/Swiss-Prot
    Q6ZUX3
    Conserved Domains (1) summary
    pfam12348
    Location:30205
    CLASP_N; CLASP N terminal
  12. XM_017003513.1XP_016859002.1  TOG array regulator of axonemal microtubules protein 2 isoform X8

RNA

  1. XR_939669.1 RNA Sequence

  2. XR_939670.1 RNA Sequence

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