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Rps6kc1 ribosomal protein S6 kinase polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 320119, updated on 12-May-2024

Summary

Official Symbol
Rps6kc1provided by MGI
Official Full Name
ribosomal protein S6 kinase polypeptide 1provided by MGI
Primary source
MGI:MGI:2443419
See related
Ensembl:ENSMUSG00000089872 AllianceGenome:MGI:2443419
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rpk118; B130003F20Rik
Summary
Predicted to enable ATP binding activity; phosphatidylinositol binding activity; and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within phosphorylation. Is active in postsynaptic density. Is expressed in olfactory epithelium and vomeronasal organ. Orthologous to human RPS6KC1 (ribosomal protein S6 kinase C1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 3.4), CNS E14 (RPKM 3.1) and 28 other tissues See more
Orthologs
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Genomic context

See Rps6kc1 in Genome Data Viewer
Location:
1 H6; 1 96.2 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (190505076..190645207, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (190772879..190913010, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38452 Neighboring gene STARR-seq mESC enhancer starr_03419 Neighboring gene predicted gene, 39738 Neighboring gene STARR-seq mESC enhancer starr_03421 Neighboring gene predicted gene, 51740 Neighboring gene STARR-positive B cell enhancer mm9_chr1:192705345-192705646 Neighboring gene STARR-positive B cell enhancer ABC_E3353 Neighboring gene angel homolog 2 Neighboring gene predicted gene, 53493 Neighboring gene vasohibin 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic density EXP
Inferred from Experiment
more info
PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ribosomal protein S6 kinase delta-1
Names
52 kDa ribosomal protein S6 kinase
S6K-delta-1
ribosomal protein S6 kinase, 52kDa, polypeptide 1
NP_848890.3
XP_006497235.1
XP_006497236.1
XP_006497237.1
XP_006497238.1
XP_011237223.1
XP_030110821.1
XP_030110822.1
XP_036021590.1
XP_036021591.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178775.4NP_848890.3  ribosomal protein S6 kinase delta-1

    Status: VALIDATED

    Source sequence(s)
    AK149858, BC058403, BG079911, CJ045347
    UniProtKB/Swiss-Prot
    Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49
    UniProtKB/TrEMBL
    E9QMX4
    Related
    ENSMUSP00000061769.9, ENSMUST00000061611.15
    Conserved Domains (5) summary
    cd07287
    Location:11128
    PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
    smart00220
    Location:8641046
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd02677
    Location:237309
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:8691046
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:334427
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    190505076..190645207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497172.4XP_006497235.1  ribosomal protein S6 kinase delta-1 isoform X1

    UniProtKB/Swiss-Prot
    Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49
    Conserved Domains (4) summary
    cd02677
    Location:225297
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:8571034
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl02563
    Location:11116
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl21453
    Location:322415
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006497175.4XP_006497238.1  ribosomal protein S6 kinase delta-1 isoform X4

    UniProtKB/Swiss-Prot
    Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49
    Conserved Domains (4) summary
    cd07287
    Location:11128
    PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
    cd05576
    Location:749926
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl00299
    Location:155189
    MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    cl21453
    Location:214307
    PKc_like; Protein Kinases, catalytic domain
  3. XM_006497173.4XP_006497236.1  ribosomal protein S6 kinase delta-1 isoform X2

    UniProtKB/Swiss-Prot
    Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49
    Conserved Domains (4) summary
    cd07287
    Location:11128
    PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
    cd02677
    Location:237309
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:8381015
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:305396
    PKc_like; Protein Kinases, catalytic domain
  4. XM_006497174.4XP_006497237.1  ribosomal protein S6 kinase delta-1 isoform X3

    UniProtKB/Swiss-Prot
    Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49
    Conserved Domains (3) summary
    cd07287
    Location:11128
    PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
    cd02677
    Location:237309
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cl21453
    Location:869960
    PKc_like; Protein Kinases, catalytic domain
  5. XM_030254962.1XP_030110822.1  ribosomal protein S6 kinase delta-1 isoform X6

    Conserved Domains (3) summary
    cd02677
    Location:56128
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:657834
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:124215
    PKc_like; Protein Kinases, catalytic domain
  6. XM_030254961.1XP_030110821.1  ribosomal protein S6 kinase delta-1 isoform X5

    UniProtKB/Swiss-Prot
    Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49
    Conserved Domains (3) summary
    cd02677
    Location:56128
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:688865
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:153246
    PKc_like; Protein Kinases, catalytic domain
  7. XM_011238921.2XP_011237223.1  ribosomal protein S6 kinase delta-1 isoform X5

    UniProtKB/Swiss-Prot
    Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49
    Conserved Domains (3) summary
    cd02677
    Location:56128
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:688865
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:153246
    PKc_like; Protein Kinases, catalytic domain
  8. XM_036165697.1XP_036021590.1  ribosomal protein S6 kinase delta-1 isoform X5

    UniProtKB/Swiss-Prot
    Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49
    Conserved Domains (3) summary
    cd02677
    Location:56128
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:688865
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:153246
    PKc_like; Protein Kinases, catalytic domain
  9. XM_036165698.1XP_036021591.1  ribosomal protein S6 kinase delta-1 isoform X7

    Conserved Domains (1) summary
    cd05576
    Location:434611
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

RNA

  1. XR_004942884.1 RNA Sequence