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RPS6KC1 ribosomal protein S6 kinase C1 [ Homo sapiens (human) ]

Gene ID: 26750, updated on 24-Nov-2020

Summary

Official Symbol
RPS6KC1provided by HGNC
Official Full Name
ribosomal protein S6 kinase C1provided by HGNC
Primary source
HGNC:HGNC:10439
See related
Ensembl:ENSG00000136643 MIM:617517
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RSKL1; RPK118; S6PKh1; humS6PKh1; S6K-delta-1
Summary
Sphingosine kinase catalyzes the formation of sphingosine 1 phosphate, a lipid cellular messenger. The protein encoded by this gene can bind to sphingosine kinase and to phosphatidylinositol 3-phosphate, suggesting a role in sphingosine 1 phophate signaling. The encoded protein can also bind to peroxiredoxin-3 and may help transport it to mitochondria. [provided by RefSeq, Mar 2017]
Expression
Ubiquitous expression in testis (RPKM 12.3), brain (RPKM 7.8) and 25 other tissues See more
Orthologs

Genomic context

See RPS6KC1 in Genome Data Viewer
Location:
1q32.3
Exon count:
22
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (213051241..213378753)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (213224588..213446808)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr1.11646 Neighboring gene angel homolog 2 Neighboring gene VISTA enhancer hs1324 Neighboring gene uncharacterized LOC105372912 Neighboring gene VISTA enhancer hs204 Neighboring gene ribosomal protein L31 pseudogene 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ribosomal protein S6 kinase delta-1
Names
52 kDa ribosomal protein S6 kinase
SPHK1-binding protein
ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein
ribosomal protein S6 kinase, 52kDa, polypeptide 1
NP_001129610.1
NP_001274147.1
NP_001274148.1
NP_001274149.1
NP_001274150.1
NP_001336575.1
NP_001336576.1
NP_001336577.1
NP_001336578.1
NP_001336579.1
NP_001336580.1
NP_001336581.1
NP_001336582.1
NP_001336583.1
NP_001336586.1
NP_001336587.1
NP_001336588.1
NP_001336589.1
NP_001336590.1
NP_001336591.1
NP_001336592.1
NP_001336593.1
NP_001336594.1
NP_001336595.1
NP_001336596.1
NP_001336597.1
NP_001336598.1
NP_001336599.1
NP_001336600.1
NP_001336601.1
NP_036556.2
XP_016856513.1
XP_016856519.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136138.4NP_001129610.1  ribosomal protein S6 kinase delta-1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.
    Source sequence(s)
    AK122921, AL583826, AL645860, DC323473
    Consensus CDS
    CCDS44317.1
    UniProtKB/Swiss-Prot
    Q96S38
    Related
    ENSP00000355926.3, ENST00000366959.4
    Conserved Domains (5) summary
    smart00220
    Location:8631044
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd02677
    Location:226300
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:8671044
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl02563
    Location:11116
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl21453
    Location:323409
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001287218.3NP_001274147.1  ribosomal protein S6 kinase delta-1 isoform c

    See identical proteins and their annotated locations for NP_001274147.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR, initiates translation at a downstream start codon, and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a. Variants 3, 4, and 15 all encode the same isoform (c).
    Source sequence(s)
    AL583826, AL645860, BC143449, DC323473
    Consensus CDS
    CCDS73029.1
    UniProtKB/TrEMBL
    F5H7T0
    Related
    ENSP00000483873.1, ENST00000614059.4
    Conserved Domains (3) summary
    cd02677
    Location:57131
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:667844
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:134209
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001287219.3NP_001274148.1  ribosomal protein S6 kinase delta-1 isoform c

    See identical proteins and their annotated locations for NP_001274148.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR, initiates translation at a downstream start codon, and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a. Variants 3, 4, and 15 all encode the same isoform (c).
    Source sequence(s)
    AK299298, AL512449, AL583826, AL645860, DC323473
    Consensus CDS
    CCDS73029.1
    UniProtKB/TrEMBL
    F5H7T0
    Related
    ENSP00000442306.1, ENST00000543470.5
    Conserved Domains (3) summary
    cd02677
    Location:57131
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:667844
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:134209
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001287220.3NP_001274149.1  ribosomal protein S6 kinase delta-1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Variants 5 and 22-30 all encode the same isoform (d).
    Source sequence(s)
    AL583826, AL645860, BC143473, DC323473
    Consensus CDS
    CCDS73030.1
    UniProtKB/TrEMBL
    A0A087X1U5
    Related
    ENSP00000484471.1, ENST00000615329.4
    Conserved Domains (1) summary
    cd05576
    Location:414591
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
  5. NM_001287221.3NP_001274150.1  ribosomal protein S6 kinase delta-1 isoform e

    See identical proteins and their annotated locations for NP_001274150.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (e) has a shorter N-terminus, compared to isoform a. Variants 6 and 9-14 all encode the same isoform (e).
    Source sequence(s)
    AL583826, BC143474, DC323473
    Consensus CDS
    CCDS73028.1
    UniProtKB/TrEMBL
    F6RJM5
    Related
    ENSP00000439282.2, ENST00000543354.5
    Conserved Domains (3) summary
    cd02677
    Location:57131
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:698875
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:154240
    PKc_like; Protein Kinases, catalytic domain
  6. NM_001349646.2NP_001336575.1  ribosomal protein S6 kinase delta-1 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) encodes isoform f.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Conserved Domains (4) summary
    cd07287
    Location:11128
    PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
    cd02677
    Location:238312
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:8481025
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:315390
    PKc_like; Protein Kinases, catalytic domain
  7. NM_001349647.2NP_001336576.1  ribosomal protein S6 kinase delta-1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) encodes isoform g.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Conserved Domains (4) summary
    cd07287
    Location:11128
    PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
    cd05576
    Location:758935
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl00299
    Location:158191
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    cl21453
    Location:214300
    PKc_like; Protein Kinases, catalytic domain
  8. NM_001349648.2NP_001336577.1  ribosomal protein S6 kinase delta-1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 6 and 10-14, encodes isoform e.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73028.1
    Conserved Domains (3) summary
    cd02677
    Location:57131
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:698875
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:154240
    PKc_like; Protein Kinases, catalytic domain
  9. NM_001349649.2NP_001336578.1  ribosomal protein S6 kinase delta-1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 6, 9, and 11-14, encodes isoform e.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73028.1
    Conserved Domains (3) summary
    cd02677
    Location:57131
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:698875
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:154240
    PKc_like; Protein Kinases, catalytic domain
  10. NM_001349650.2NP_001336579.1  ribosomal protein S6 kinase delta-1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 6, 9, 10, and 12-14, encodes isoform e.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73028.1
    Conserved Domains (3) summary
    cd02677
    Location:57131
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:698875
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:154240
    PKc_like; Protein Kinases, catalytic domain
  11. NM_001349651.2NP_001336580.1  ribosomal protein S6 kinase delta-1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 6, 9-11, 13, and 14, encodes isoform e.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73028.1
    Conserved Domains (3) summary
    cd02677
    Location:57131
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:698875
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:154240
    PKc_like; Protein Kinases, catalytic domain
  12. NM_001349652.2NP_001336581.1  ribosomal protein S6 kinase delta-1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 6, 9-12, and 14, encodes isoform e.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73028.1
    Conserved Domains (3) summary
    cd02677
    Location:57131
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:698875
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:154240
    PKc_like; Protein Kinases, catalytic domain
  13. NM_001349653.2NP_001336582.1  ribosomal protein S6 kinase delta-1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 6 and 9-13, encodes isoform e.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73028.1
    Conserved Domains (3) summary
    cd02677
    Location:57131
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:698875
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:154240
    PKc_like; Protein Kinases, catalytic domain
  14. NM_001349654.2NP_001336583.1  ribosomal protein S6 kinase delta-1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 3 and 4, encodes isoform c.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73029.1
    Conserved Domains (3) summary
    cd02677
    Location:57131
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:667844
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:134209
    PKc_like; Protein Kinases, catalytic domain
  15. NM_001349657.2NP_001336586.1  ribosomal protein S6 kinase delta-1 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variant 17, encodes isoform h.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Conserved Domains (2) summary
    cd05576
    Location:582759
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:38124
    PKc_like; Protein Kinases, catalytic domain
  16. NM_001349658.2NP_001336587.1  ribosomal protein S6 kinase delta-1 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variant 16, encodes isoform h.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Conserved Domains (2) summary
    cd05576
    Location:582759
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:38124
    PKc_like; Protein Kinases, catalytic domain
  17. NM_001349659.2NP_001336588.1  ribosomal protein S6 kinase delta-1 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 19-21, encodes isoform i.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Conserved Domains (2) summary
    cd05576
    Location:527704
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:169
    PKc_like; Protein Kinases, catalytic domain
  18. NM_001349660.2NP_001336589.1  ribosomal protein S6 kinase delta-1 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variants 18, 20, and 21, encodes isoform i.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Conserved Domains (2) summary
    cd05576
    Location:527704
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:169
    PKc_like; Protein Kinases, catalytic domain
  19. NM_001349661.2NP_001336590.1  ribosomal protein S6 kinase delta-1 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variants 18, 19, and 21, encodes isoform i.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Conserved Domains (2) summary
    cd05576
    Location:527704
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:169
    PKc_like; Protein Kinases, catalytic domain
  20. NM_001349662.2NP_001336591.1  ribosomal protein S6 kinase delta-1 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variants 18-20, encodes isoform i.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Conserved Domains (2) summary
    cd05576
    Location:527704
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:169
    PKc_like; Protein Kinases, catalytic domain
  21. NM_001349663.2NP_001336592.1  ribosomal protein S6 kinase delta-1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variants 5 and 23-30, encodes isoform d.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73030.1
    Conserved Domains (1) summary
    cd05576
    Location:414591
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
  22. NM_001349664.2NP_001336593.1  ribosomal protein S6 kinase delta-1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variants 5, 22, and 24-30, encodes isoform d.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73030.1
    Conserved Domains (1) summary
    cd05576
    Location:414591
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
  23. NM_001349665.2NP_001336594.1  ribosomal protein S6 kinase delta-1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24), as well as variants 5, 23, and 25-30, encodes isoform d.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73030.1
    Conserved Domains (1) summary
    cd05576
    Location:414591
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
  24. NM_001349666.2NP_001336595.1  ribosomal protein S6 kinase delta-1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variants 5, 23, 24, and 26-30, encodes isoform d.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73030.1
    Conserved Domains (1) summary
    cd05576
    Location:414591
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
  25. NM_001349667.2NP_001336596.1  ribosomal protein S6 kinase delta-1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26), as well as variants 5, 23-25, and 27-30, encodes isoform d.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73030.1
    Conserved Domains (1) summary
    cd05576
    Location:414591
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
  26. NM_001349668.2NP_001336597.1  ribosomal protein S6 kinase delta-1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (27), as well as variants 5, 23-26, and 28-30, encodes isoform d.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73030.1
    Conserved Domains (1) summary
    cd05576
    Location:414591
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
  27. NM_001349669.2NP_001336598.1  ribosomal protein S6 kinase delta-1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (28), as well as variants 5, 23-27, 29, and 30, encodes isoform d.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73030.1
    Conserved Domains (1) summary
    cd05576
    Location:414591
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
  28. NM_001349670.2NP_001336599.1  ribosomal protein S6 kinase delta-1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (29), as well as variants 5, 23-28, and 30, encodes isoform d.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73030.1
    Conserved Domains (1) summary
    cd05576
    Location:414591
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
  29. NM_001349671.2NP_001336600.1  ribosomal protein S6 kinase delta-1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (30), as well as variants 5 and 23-29, encodes isoform d.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Consensus CDS
    CCDS73030.1
    Conserved Domains (1) summary
    cd05576
    Location:414591
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
  30. NM_001349672.2NP_001336601.1  ribosomal protein S6 kinase delta-1 isoform j

    Status: REVIEWED

    Description
    Transcript Variant: This variant (31) encodes isoform j.
    Source sequence(s)
    AL512449, AL583826, AL645860
    Conserved Domains (1) summary
    cl21453
    Location:414561
    PKc_like; Protein Kinases, catalytic domain
  31. NM_012424.6NP_036556.2  ribosomal protein S6 kinase delta-1 isoform a

    See identical proteins and their annotated locations for NP_036556.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK122989, AL512449, AL583826, AL645860, DC323473
    Consensus CDS
    CCDS1513.1
    UniProtKB/Swiss-Prot
    Q96S38
    Related
    ENSP00000355927.3, ENST00000366960.8
    Conserved Domains (5) summary
    cd07287
    Location:11128
    PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
    smart00220
    Location:8751056
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd02677
    Location:238312
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:8791056
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:335421
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_146207.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL512449, AL583826, AL645860
  2. NR_146208.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL512449, AL583826, AL645860
  3. NR_146209.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL512449, AL583826, AL645860
  4. NR_146210.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL512449, AL583826, AL645860

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    213051241..213378753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001030.1XP_016856519.1  ribosomal protein S6 kinase delta-1 isoform X2

    Conserved Domains (2) summary
    cd05576
    Location:527704
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:169
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017001024.1XP_016856513.1  ribosomal protein S6 kinase delta-1 isoform X1

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