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HNRNPL heterogeneous nuclear ribonucleoprotein L [ Homo sapiens (human) ]

Gene ID: 3191, updated on 4-Dec-2022

Summary

Official Symbol
HNRNPLprovided by HGNC
Official Full Name
heterogeneous nuclear ribonucleoprotein Lprovided by HGNC
Primary source
HGNC:HGNC:5045
See related
Ensembl:ENSG00000104824 MIM:603083; AllianceGenome:HGNC:5045
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HNRPL; hnRNP-L; P/OKcl.14
Summary
Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 99.2), lymph node (RPKM 60.1) and 25 other tissues See more
Orthologs
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Genomic context

See HNRNPL in Genome Data Viewer
Location:
19q13.2
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (38836370..38852347, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (41640403..41656404, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39327010..39342987, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene galectin 4 Neighboring gene uncharacterized LOC124904712 Neighboring gene enoyl-CoA hydratase 1 Neighboring gene Sharpr-MPRA regulatory region 3140 Neighboring gene Ras and Rab interactor like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human heterogeneous nuclear ribonucleoprotein L (HNRNPL) at amino acid residues 392-393 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35509

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables mRNA 3'-UTR binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA CDS binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables pre-mRNA intronic binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA processing TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to amino acid starvation IEA
Inferred from Electronic Annotation
more info
 
involved_in circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mRNA binding IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to peptide IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in membrane HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
heterogeneous nuclear ribonucleoprotein L
Names
epididymis secretory sperm binding protein
hnRNP L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005335.2NP_001005335.1  heterogeneous nuclear ribonucleoprotein L isoform b

    See identical proteins and their annotated locations for NP_001005335.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AB044547, AC008982, AK094966, AV743120, BC069184, BI256815, BM997815, BQ334900, X16135
    Consensus CDS
    CCDS33016.1
    UniProtKB/Swiss-Prot
    P14866
    UniProtKB/TrEMBL
    Q6NTA2
    Related
    ENSP00000470231.1, ENST00000600873.5
    Conserved Domains (1) summary
    TIGR01649
    Location:1454
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
  2. NM_001385651.1NP_001372580.1  heterogeneous nuclear ribonucleoprotein L isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a retained intron compared to variant 1. The encoded isoform (c) is longer than isoform a
    Source sequence(s)
    AC008982
    Related
    ENSP00000497920.1, ENST00000647557.1
    Conserved Domains (1) summary
    TIGR01649
    Location:100624
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
  3. NM_001533.3NP_001524.2  heterogeneous nuclear ribonucleoprotein L isoform a

    See identical proteins and their annotated locations for NP_001524.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AB044547, AC008982
    Consensus CDS
    CCDS33015.1
    UniProtKB/Swiss-Prot
    P14866, Q9H3P3
    UniProtKB/TrEMBL
    Q6NTA2
    Related
    ENSP00000221419.4, ENST00000221419.10
    Conserved Domains (1) summary
    TIGR01649
    Location:100587
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    38836370..38852347 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438739.1XP_047294695.1  heterogeneous nuclear ribonucleoprotein L isoform X4

  2. XM_011526888.3XP_011525190.1  heterogeneous nuclear ribonucleoprotein L isoform X2

    Conserved Domains (5) summary
    cd12699
    Location:322395
    RRM3_hnRNPL; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)
    cd12704
    Location:438521
    RRM4_hnRNPL; RNA recognition motif 4 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)
    cd12780
    Location:100179
    RRM1_hnRNPL; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)
    TIGR01649
    Location:100526
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    cl17169
    Location:189227
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. XM_047438738.1XP_047294694.1  heterogeneous nuclear ribonucleoprotein L isoform X3

  4. XM_047438737.1XP_047294693.1  heterogeneous nuclear ribonucleoprotein L isoform X1

    Related
    ENSP00000469349.1, ENST00000601449.5
  5. XM_047438740.1XP_047294696.1  heterogeneous nuclear ribonucleoprotein L isoform X5

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_014040929.1 Reference GRCh38.p14 PATCHES

    Range
    246042..262019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    41640403..41656404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)