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HNRNPL heterogeneous nuclear ribonucleoprotein L [ Homo sapiens (human) ]

Gene ID: 3191, updated on 17-Jun-2019

Summary

Official Symbol
HNRNPLprovided by HGNC
Official Full Name
heterogeneous nuclear ribonucleoprotein Lprovided by HGNC
Primary source
HGNC:HGNC:5045
See related
Ensembl:ENSG00000104824 MIM:603083
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HNRPL; hnRNP-L; P/OKcl.14
Summary
Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 99.2), lymph node (RPKM 60.1) and 25 other tissues See more
Orthologs

Genomic context

See HNRNPL in Genome Data Viewer
Location:
19q13.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (38836370..38852347, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39327028..39342979, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene galectin 4 Neighboring gene enoyl-CoA hydratase 1 Neighboring gene Ras and Rab interactor like Neighboring gene sirtuin 2 Neighboring gene NFKB inhibitor beta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human heterogeneous nuclear ribonucleoprotein L (HNRNPL) at amino acid residues 392-393 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
    Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
  • mRNA Processing, organism-specific biosystem (from WikiPathways)
    mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
  • mRNA Splicing, organism-specific biosystem (from REACTOME)
    mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
  • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
    mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35509

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
pre-mRNA intronic binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA metabolic process TAS
Traceable Author Statement
more info
 
RNA processing TAS
Traceable Author Statement
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
membrane HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
heterogeneous nuclear ribonucleoprotein L
Names
epididymis secretory sperm binding protein
hnRNP L

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005335.2NP_001005335.1  heterogeneous nuclear ribonucleoprotein L isoform b

    See identical proteins and their annotated locations for NP_001005335.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AB044547, AC008982, AK094966, AV743120, BC069184, BI256815, BM997815, BQ334900, X16135
    Consensus CDS
    CCDS33016.1
    UniProtKB/Swiss-Prot
    P14866
    UniProtKB/TrEMBL
    Q6NTA2
    Related
    ENSP00000470231.1, ENST00000600873.5
    Conserved Domains (1) summary
    TIGR01649
    Location:1454
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
  2. NM_001533.2NP_001524.2  heterogeneous nuclear ribonucleoprotein L isoform a

    See identical proteins and their annotated locations for NP_001524.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AB044547, AK094966, AV743120, BC069184, BI461733, BM997815, BQ334900, X16135
    Consensus CDS
    CCDS33015.1
    UniProtKB/Swiss-Prot
    P14866
    UniProtKB/TrEMBL
    Q6NTA2
    Related
    ENSP00000221419.4, ENST00000221419.9
    Conserved Domains (1) summary
    TIGR01649
    Location:100587
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    38836370..38852347 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451482.1XP_024307250.1  heterogeneous nuclear ribonucleoprotein L isoform X5

    Conserved Domains (1) summary
    TIGR01649
    Location:1491
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
  2. XM_024451483.1XP_024307251.1  heterogeneous nuclear ribonucleoprotein L isoform X5

    Conserved Domains (1) summary
    TIGR01649
    Location:1491
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
  3. XM_024451479.1XP_024307247.1  heterogeneous nuclear ribonucleoprotein L isoform X1

    Conserved Domains (1) summary
    TIGR01649
    Location:100624
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
  4. XM_011526888.2XP_011525190.1  heterogeneous nuclear ribonucleoprotein L isoform X4

    Conserved Domains (5) summary
    cd12699
    Location:322395
    RRM3_hnRNPL; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)
    cd12704
    Location:438521
    RRM4_hnRNPL; RNA recognition motif 4 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)
    cd12780
    Location:100179
    RRM1_hnRNPL; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)
    TIGR01649
    Location:100526
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    cl17169
    Location:189227
    RRM_SF; RNA recognition motif (RRM) superfamily
  5. XM_024451481.1XP_024307249.1  heterogeneous nuclear ribonucleoprotein L isoform X3

    Conserved Domains (1) summary
    TIGR01649
    Location:43567
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
  6. XM_024451480.1XP_024307248.1  heterogeneous nuclear ribonucleoprotein L isoform X2

    Related
    ENSP00000497920.1, ENST00000647557.1
    Conserved Domains (1) summary
    TIGR01649
    Location:29553
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

RNA

  1. XR_243927.2 RNA Sequence

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_014040929.1 Reference GRCh38.p13 PATCHES

    Range
    246042..262019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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