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Hnrnpl heterogeneous nuclear ribonucleoprotein L [ Mus musculus (house mouse) ]

Gene ID: 15388, updated on 21-Apr-2024

Summary

Official Symbol
Hnrnplprovided by MGI
Official Full Name
heterogeneous nuclear ribonucleoprotein Lprovided by MGI
Primary source
MGI:MGI:104816
See related
Ensembl:ENSMUSG00000015165 AllianceGenome:MGI:104816
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hnrpl; D830027H13Rik
Summary
Enables RNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Located in pronucleus. Is expressed in several structures, including central nervous system; early conceptus; sensory organ; tail unsegmented mesenchyme; and tooth. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and systemic scleroderma. Orthologous to human HNRNPL (heterogeneous nuclear ribonucleoprotein L). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 136.9), limb E14.5 (RPKM 90.8) and 28 other tissues See more
Orthologs
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Genomic context

Location:
7 B1; 7 16.93 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28507971..28521693)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28808546..28822268)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene sirtuin 2 Neighboring gene predicted gene, 19897 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29565175-29565376 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29565964-29566190 Neighboring gene STARR-positive B cell enhancer ABC_E6528 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29577451-29577634 Neighboring gene Ras and Rab interactor-like Neighboring gene nuclear encoded tRNA lysine 24 (anticodon TTT) Neighboring gene STARR-seq mESC enhancer starr_18438 Neighboring gene STARR-positive B cell enhancer ABC_E156 Neighboring gene STARR-positive B cell enhancer ABC_E8158 Neighboring gene STARR-seq mESC enhancer starr_18440 Neighboring gene enoyl coenzyme A hydratase 1, peroxisomal Neighboring gene lectin, galactose binding, soluble 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA CDS binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables pre-mRNA intronic binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in pronucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 
located_in ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
heterogeneous nuclear ribonucleoprotein L
Names
hnRNP L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402935.1NP_001389864.1  heterogeneous nuclear ribonucleoprotein L isoform a

    Status: VALIDATED

    Source sequence(s)
    AC171210
    Related
    ENSMUSP00000134734.2, ENSMUST00000174477.8
  2. NM_001402936.1NP_001389865.1  heterogeneous nuclear ribonucleoprotein L isoform c

    Status: VALIDATED

    Source sequence(s)
    AC171210
    Conserved Domains (1) summary
    TIGR01649
    Location:1491
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
  3. NM_001402937.1NP_001389866.1  heterogeneous nuclear ribonucleoprotein L isoform c

    Status: VALIDATED

    Source sequence(s)
    AC171210
    Conserved Domains (1) summary
    TIGR01649
    Location:1491
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
  4. NM_001402938.1NP_001389867.1  heterogeneous nuclear ribonucleoprotein L isoform d

    Status: VALIDATED

    Source sequence(s)
    AC171210
    UniProtKB/TrEMBL
    G3UY38
    Related
    ENSMUSP00000133932.2, ENSMUST00000172529.8
  5. NM_001402939.1NP_001389868.1  heterogeneous nuclear ribonucleoprotein L isoform d

    Status: VALIDATED

    Source sequence(s)
    AC171210
    UniProtKB/TrEMBL
    G3UY38
  6. NM_177301.6NP_796275.3  heterogeneous nuclear ribonucleoprotein L isoform b

    See identical proteins and their annotated locations for NP_796275.3

    Status: VALIDATED

    Source sequence(s)
    AC171210
    Consensus CDS
    CCDS39864.2
    UniProtKB/Swiss-Prot
    O54789, Q499X2, Q8K0S7, Q8R081
    UniProtKB/TrEMBL
    Q3UMT7
    Related
    ENSMUSP00000133728.2, ENSMUST00000174548.8
    Conserved Domains (1) summary
    TIGR01649
    Location:97584
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

RNA

  1. NR_175319.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC171210
  2. NR_175320.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC171210
    Related
    ENSMUST00000174882.8
  3. NR_175321.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC171210
  4. NR_175322.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC171210
  5. NR_175323.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC171210

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    28507971..28521693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539560.2XP_006539623.1  heterogeneous nuclear ribonucleoprotein L isoform X5

    Conserved Domains (1) summary
    TIGR01649
    Location:97291
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
  2. XM_036152696.1XP_036008589.1  heterogeneous nuclear ribonucleoprotein L isoform X6

    Conserved Domains (1) summary
    TIGR01649
    Location:97292
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

RNA

  1. XR_003946390.1 RNA Sequence

  2. XR_004934017.1 RNA Sequence