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HMOX1 heme oxygenase 1 [ Homo sapiens (human) ]

Gene ID: 3162, updated on 1-Jun-2020

Summary

Official Symbol
HMOX1provided by HGNC
Official Full Name
heme oxygenase 1provided by HGNC
Primary source
HGNC:HGNC:5013
See related
Ensembl:ENSG00000100292 MIM:141250
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HO-1; HSP32; HMOX1D; bK286B10
Summary
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 208.2), ovary (RPKM 68.8) and 17 other tissues See more
Orthologs

Genomic context

See HMOX1 in Genome Data Viewer
Location:
22q12.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (35381096..35394207)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (35777060..35790207)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene target of myb1 membrane trafficking protein Neighboring gene microRNA 3909 Neighboring gene microRNA 6069 Neighboring gene minichromosome maintenance complex component 5 Neighboring gene tRNA methyltransferase 11 homolog (S. cerevisiae) pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Chronic obstructive pulmonary disease
MedGen: C0024117 OMIM: 606963 GeneReviews: Not available
Compare labs
Heme oxygenase 1 deficiency
MedGen: C1841651 OMIM: 614034 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 (BAL-1, Jago, SF162, YU2, ADA, 89.6, Doge, JR-CSF, BL-3, JRFL and HIV-2 TYBE) replication decreases HMOX1 expression in monocyte-derived macrophages; extent of replication appears to be proportional to extent HMOX1 deficiency PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 significantly upregulates Nrf2 in human astrocytes and is associated with increased levels of key antioxidant defensive enzymes Hemoxygenase (HO-1) and NAD(P)H dehydrogenase quinone1 (Nqo1) PubMed
Nef nef HMOX1 mRNA is selectively retained in HIV-1 Nef-expressing cellular exosomes, and five miRNAs (miR-15b, miR-26b*, miR-125b, let-7a, and let-7e*) which target HMOX1 mRNA are selectively secreted in exosomes from these cells PubMed
Tat tat HIV-1 Tat upregulates NQO1, CAT, SOD1, SOD2, and HMOX1 (HO1) mRNA levels in SH-SY5Y cells PubMed
tat HO-1 modulates the inhibitory effect of celastro on HIV-1 Tat-induced upregulation of ICAM-1 and VCAM-1, and release of CXCL10, IL-8, and MCP-1 in human astroglioma cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heme binding IDA
Inferred from Direct Assay
more info
PubMed 
heme oxygenase (decyclizing) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heme oxygenase (decyclizing) activity IDA
Inferred from Direct Assay
more info
PubMed 
heme oxygenase (decyclizing) activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phospholipase D activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
structural molecule activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
angiogenesis TAS
Traceable Author Statement
more info
PubMed 
cell death ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular iron ion homeostasis TAS
Traceable Author Statement
more info
 
cellular response to arsenic-containing substance IEA
Inferred from Electronic Annotation
more info
 
cellular response to cadmium ion IEA
Inferred from Electronic Annotation
more info
 
cellular response to cisplatin IEA
Inferred from Electronic Annotation
more info
 
cellular response to heat IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to nutrient IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
endothelial cell proliferation TAS
Traceable Author Statement
more info
PubMed 
erythrocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
excretion IC
Inferred by Curator
more info
PubMed 
heme catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heme catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
heme catabolic process TAS
Traceable Author Statement
more info
 
heme oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heme oxidation IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 
iron ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
iron ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
liver regeneration IEA
Inferred from Electronic Annotation
more info
 
low-density lipoprotein particle clearance TAS
Traceable Author Statement
more info
PubMed 
negative regulation of DNA binding IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epithelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of leukocyte migration TAS
Traceable Author Statement
more info
PubMed 
negative regulation of macroautophagy IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mast cell cytokine production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mast cell degranulation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of vascular smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling HMP PubMed 
positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood vessel diameter IC
Inferred by Curator
more info
PubMed 
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell migration involved in sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of chemokine biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of macroautophagy IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of angiogenesis TAS
Traceable Author Statement
more info
PubMed 
regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription from RNA polymerase II promoter in response to iron IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription from RNA polymerase II promoter in response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
response to estrogen IEA
Inferred from Electronic Annotation
more info
 
response to hydrogen peroxide ISS
Inferred from Sequence or Structural Similarity
more info
 
response to nicotine IDA
Inferred from Direct Assay
more info
PubMed 
response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
smooth muscle hyperplasia TAS
Traceable Author Statement
more info
PubMed 
wound healing involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
caveola IEA
Inferred from Electronic Annotation
more info
 
cell IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
extracellular space TAS
Traceable Author Statement
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
heme oxygenase 1
Names
heat shock protein, 32-kD
heme oxygenase (decycling) 1
NP_002124.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023030.1 RefSeqGene

    Range
    5030..18141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002133.3NP_002124.1  heme oxygenase 1

    See identical proteins and their annotated locations for NP_002124.1

    Status: REVIEWED

    Source sequence(s)
    BP288767, CA306357, X06985
    Consensus CDS
    CCDS13914.1
    UniProtKB/Swiss-Prot
    P09601
    UniProtKB/TrEMBL
    Q6FH11
    Related
    ENSP00000216117.8, ENST00000216117.9
    Conserved Domains (1) summary
    pfam01126
    Location:11216
    Heme_oxygenase; Heme oxygenase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    35381096..35394207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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