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Hmox1 heme oxygenase 1 [ Mus musculus (house mouse) ]

Gene ID: 15368, updated on 29-Jan-2023

Summary

Official Symbol
Hmox1provided by MGI
Official Full Name
heme oxygenase 1provided by MGI
Primary source
MGI:MGI:96163
See related
Ensembl:ENSMUSG00000005413 AllianceGenome:MGI:96163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HO1; HO-1; Hmox; Hemox; Hsp32; D8Wsu38e
Summary
Predicted to enable several functions, including heme binding activity; heme oxygenase (decyclizing) activity; and protein homodimerization activity. Acts upstream of or within several processes, including cellular response to cisplatin; cellular response to metal ion; and regulation of macroautophagy. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study hemochromatosis and malaria. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); factor VIII deficiency; lung disease (multiple); and sickle cell anemia. Orthologous to human HMOX1 (heme oxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 123.6), spleen adult (RPKM 121.0) and 13 other tissues See more
Orthologs
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Genomic context

See Hmox1 in Genome Data Viewer
Location:
8 35.59 cM; 8 C1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (75820246..75827221)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (75093618..75100593)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene target of myb1 trafficking protein Neighboring gene dpy-30 homolog pseudogene Neighboring gene minichromosome maintenance complex component 5 Neighboring gene RASD family, member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (11)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heme binding ISO
Inferred from Sequence Orthology
more info
 
enables heme oxygenase (decyclizing) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heme oxygenase (decyclizing) activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase D activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables structural molecule activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to arsenic-containing substance IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to cadmium ion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to cisplatin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in erythrocyte homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in heme catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in heme catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heme metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in heme oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in heme oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
involved_in iron ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in liver regeneration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mast cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mast cell degranulation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of transcription from RNA polymerase II promoter in response to iron IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription from RNA polymerase II promoter in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to nicotine ISO
Inferred from Sequence Orthology
more info
 
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
heme oxygenase 1
Names
P32 protein
heme oxygenase (decycling) 1
hemoxygenase
NP_034572.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010442.2NP_034572.1  heme oxygenase 1

    See identical proteins and their annotated locations for NP_034572.1

    Status: VALIDATED

    Source sequence(s)
    AA186175, AK150934, BY319630
    Consensus CDS
    CCDS22423.1
    UniProtKB/Swiss-Prot
    P14901
    UniProtKB/TrEMBL
    Q3U5U6
    Related
    ENSMUSP00000005548.7, ENSMUST00000005548.8
    Conserved Domains (1) summary
    pfam01126
    Location:11216
    Heme_oxygenase; Heme oxygenase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    75820246..75827221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)