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HMGN1 high mobility group nucleosome binding domain 1 [ Homo sapiens (human) ]

Gene ID: 3150, updated on 11-Sep-2019

Summary

Official Symbol
HMGN1provided by HGNC
Official Full Name
high mobility group nucleosome binding domain 1provided by HGNC
Primary source
HGNC:HGNC:4984
See related
Ensembl:ENSG00000205581 MIM:163920
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HMG14
Summary
The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 44.3), lymph node (RPKM 41.2) and 25 other tissues See more
Orthologs

Genomic context

See HMGN1 in Genome Data Viewer
Location:
21q22.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (39342315..39349088, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (40714241..40721047, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene bromodomain and WD repeat domain containing 1 Neighboring gene BRWD1 antisense RNA 2 Neighboring gene BRWD1 antisense RNA 1 Neighboring gene uncharacterized LOC105372804 Neighboring gene ring finger protein 6 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat specifically associates with HMGN1 promoter to upregulate HMGN1 expression in T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • ATM Signaling Network in Development and Disease, organism-specific biosystem (from WikiPathways)
    ATM Signaling Network in Development and Disease, organism-specific biosystemThis pathway is modeled after Figure 4 in the article "The ATM signaling network in development and disease" (See Bibliography). When DNA is damaged, DDR begins to work on recuperating the damage th...
  • DNA Repair, organism-specific biosystem (from REACTOME)
    DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
  • Dual incision in TC-NER, organism-specific biosystem (from REACTOME)
    Dual incision in TC-NER, organism-specific biosystemIn transcription-coupled nucleotide excision repair (TC-NER), similar to global genome nucleotide excision repair (GG-NER), the oligonucleotide that contains the lesion is excised from the open bubbl...
  • Formation of TC-NER Pre-Incision Complex, organism-specific biosystem (from REACTOME)
    Formation of TC-NER Pre-Incision Complex, organism-specific biosystemFormation of TC-NER pre-incision complex is initiated when the RNA polymerase II (RNA Pol II) complex stalls at a DNA damage site. The stalling is caused by misincorporation of a ribonucleotide oppos...
  • Gap-filling DNA repair synthesis and ligation in TC-NER, organism-specific biosystem (from REACTOME)
    Gap-filling DNA repair synthesis and ligation in TC-NER, organism-specific biosystemIn transcription-coupled nucleotide excision repair (TC-NER), similar to global genome nucleotide excision repair (GG-NER), DNA polymerases delta or epsilon, or the Y family DNA polymerase kappa, fil...
  • Herpes simplex infection, organism-specific biosystem (from KEGG)
    Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Herpes simplex infection, conserved biosystem (from KEGG)
    Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Nucleotide Excision Repair, organism-specific biosystem (from REACTOME)
    Nucleotide Excision Repair, organism-specific biosystemNucleotide excision repair (NER) was first described in the model organism E. coli in the early 1960s as a process whereby bulky base damage is enzymatically removed from DNA, facilitating the recove...
  • Transcription-Coupled Nucleotide Excision Repair (TC-NER), organism-specific biosystem (from REACTOME)
    Transcription-Coupled Nucleotide Excision Repair (TC-NER), organism-specific biosystemDNA damage in transcribed strands of active genes is repaired through a specialized nucleotide excision repair (NER) pathway known as transcription-coupled nucleotide excision repair (TC-NER). TC-NER...
  • p38 MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    p38 MAPK Signaling Pathway, organism-specific biosystemp38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ27265, FLJ31471, MGC104230, MGC117425

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
nucleosomal DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA-templated transcription, elongation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of NAD+ ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
post-embryonic camera-type eye morphogenesis IEA
Inferred from Electronic Annotation
more info
 
pyrimidine dimer repair by nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
 
regulation of development, heterochronic IEA
Inferred from Electronic Annotation
more info
 
regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
response to UV-B IEA
Inferred from Electronic Annotation
more info
 
response to UV-C IEA
Inferred from Electronic Annotation
more info
 
transcription-coupled nucleotide-excision repair TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
chromatin IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
non-histone chromosomal protein HMG-14
Names
high mobility group nucleosome-binding domain-containing protein 1
high-mobility group (nonhistone chromosomal) protein 14
high-mobility group nucleosome binding 1
nonhistone chromosomal protein HMG-14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004965.7NP_004956.5  non-histone chromosomal protein HMG-14

    See identical proteins and their annotated locations for NP_004956.5

    Status: REVIEWED

    Source sequence(s)
    AL582106, BC070154, BE779939
    Consensus CDS
    CCDS33559.1
    UniProtKB/Swiss-Prot
    P05114
    UniProtKB/TrEMBL
    Q6NSG7
    Related
    ENSP00000370125.5, ENST00000380749.10
    Conserved Domains (1) summary
    pfam01101
    Location:194
    HMG14_17; HMG14 and HMG17

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    39342315..39349088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529549.2XP_011527851.1  non-histone chromosomal protein HMG-14 isoform X1

    See identical proteins and their annotated locations for XP_011527851.1

  2. XM_024452069.1XP_024307837.1  non-histone chromosomal protein HMG-14 isoform X1

  3. XM_017028336.2XP_016883825.1  non-histone chromosomal protein HMG-14 isoform X1

  4. XM_024452068.1XP_024307836.1  non-histone chromosomal protein HMG-14 isoform X1

  5. XM_017028333.2XP_016883822.1  non-histone chromosomal protein HMG-14 isoform X1

  6. XM_011529544.2XP_011527846.1  non-histone chromosomal protein HMG-14 isoform X1

    See identical proteins and their annotated locations for XP_011527846.1

  7. XM_011529543.2XP_011527845.1  non-histone chromosomal protein HMG-14 isoform X1

    See identical proteins and their annotated locations for XP_011527845.1

  8. XM_024452067.1XP_024307835.1  non-histone chromosomal protein HMG-14 isoform X1

  9. XM_017028335.2XP_016883824.1  non-histone chromosomal protein HMG-14 isoform X1

  10. XM_024452070.1XP_024307838.1  non-histone chromosomal protein HMG-14 isoform X1

  11. XM_017028334.1XP_016883823.1  non-histone chromosomal protein HMG-14 isoform X1

  12. XM_024452071.1XP_024307839.1  non-histone chromosomal protein HMG-14 isoform X1

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