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HMGN1 high mobility group nucleosome binding domain 1 [ Homo sapiens (human) ]

Gene ID: 3150, updated on 9-Jul-2021

Summary

Official Symbol
HMGN1provided by HGNC
Official Full Name
high mobility group nucleosome binding domain 1provided by HGNC
Primary source
HGNC:HGNC:4984
See related
Ensembl:ENSG00000205581 MIM:163920
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HMG14
Summary
The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 44.3), lymph node (RPKM 41.2) and 25 other tissues See more
Orthologs
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Genomic context

See HMGN1 in Genome Data Viewer
Location:
21q22.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (39342315..39349088, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (40714241..40721014, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene bromodomain and WD repeat domain containing 1 Neighboring gene BRWD1 antisense RNA 2 Neighboring gene BRWD1 antisense RNA 1 Neighboring gene uncharacterized LOC105372804 Neighboring gene ring finger protein 6 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat specifically associates with HMGN1 promoter to upregulate HMGN1 expression in T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ27265, FLJ31471, MGC104230, MGC117425

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding TAS
Traceable Author Statement
more info
PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleosomal DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
non-histone chromosomal protein HMG-14
Names
high mobility group nucleosome-binding domain-containing protein 1
high-mobility group (nonhistone chromosomal) protein 14
high-mobility group nucleosome binding 1
nonhistone chromosomal protein HMG-14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004965.7NP_004956.5  non-histone chromosomal protein HMG-14

    See identical proteins and their annotated locations for NP_004956.5

    Status: REVIEWED

    Source sequence(s)
    AL582106, BC070154, BE779939
    Consensus CDS
    CCDS33559.1
    UniProtKB/Swiss-Prot
    P05114
    UniProtKB/TrEMBL
    Q6NSG7
    Related
    ENSP00000370125.5, ENST00000380749.10
    Conserved Domains (1) summary
    pfam01101
    Location:194
    HMG14_17; HMG14 and HMG17

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    39342315..39349088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529549.2XP_011527851.1  non-histone chromosomal protein HMG-14 isoform X1

    See identical proteins and their annotated locations for XP_011527851.1

  2. XM_024452069.1XP_024307837.1  non-histone chromosomal protein HMG-14 isoform X1

  3. XM_017028336.2XP_016883825.1  non-histone chromosomal protein HMG-14 isoform X1

  4. XM_024452068.1XP_024307836.1  non-histone chromosomal protein HMG-14 isoform X1

  5. XM_017028333.2XP_016883822.1  non-histone chromosomal protein HMG-14 isoform X1

  6. XM_011529544.2XP_011527846.1  non-histone chromosomal protein HMG-14 isoform X1

    See identical proteins and their annotated locations for XP_011527846.1

  7. XM_011529543.2XP_011527845.1  non-histone chromosomal protein HMG-14 isoform X1

    See identical proteins and their annotated locations for XP_011527845.1

  8. XM_024452067.1XP_024307835.1  non-histone chromosomal protein HMG-14 isoform X1

    Related
    ENST00000486741.5
  9. XM_017028335.2XP_016883824.1  non-histone chromosomal protein HMG-14 isoform X1

  10. XM_024452070.1XP_024307838.1  non-histone chromosomal protein HMG-14 isoform X1

  11. XM_017028334.1XP_016883823.1  non-histone chromosomal protein HMG-14 isoform X1

    Related
    ENST00000492280.5
  12. XM_024452071.1XP_024307839.1  non-histone chromosomal protein HMG-14 isoform X1

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