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Ephb2 Eph receptor B2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313633, updated on 10-Feb-2026
Symbol
Ephb2provided by RGD
Full Name
Eph receptor B2provided by RGD
Primary source
RGD:1564232
See related
Ensembl:ENSRNOG00000012531 AllianceGenome:RGD:1564232
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564232
Summary
Predicted to enable several functions, including amyloid-beta binding activity; identical protein binding activity; and transmembrane signaling receptor activity. Involved in several processes, including cell junction assembly; positive regulation of nervous system development; and positive regulation of protein localization. Located in cell surface; dendritic spine; and neuronal cell body. Is active in glutamatergic synapse. Used to study irritable bowel syndrome and ulcerative colitis. Biomarker of irritable bowel syndrome and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in blood platelet disease. Orthologous to human EPHB2 (EPH receptor B2). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Thymus (RPKM 50.5), Kidney (RPKM 28.4) and 8 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Ephb2 in Genome Data Viewer
Location:
5q36
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (154179065..154360459, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (148889574..149077027, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (155024478..155143539, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103012 Neighboring gene testis expressed 46 Neighboring gene lactamase beta like 1 Neighboring gene uncharacterized LOC134487018 Neighboring gene complement C1q B chain Neighboring gene complement C1q C chain

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. The ephrin receptor EphB2 regulates the connectivity and activity of enteric neurons. Bodin R, et al. J Biol Chem, 2021 Nov. PMID 34648765, Free PMC Article
  2. Expression of EphB2 in the development of anorectal malformations in fetal rats. Wang DJ, et al. J Pediatr Surg, 2009 Mar. PMID 19302865
  3. Blockade of EphB2 enhances neurogenesis in the subventricular zone and improves neurological function after cerebral cortical infarction in hypertensive rats. Xing S, et al. Brain Res, 2008 Sep 16. PMID 18639535
  4. Preferential control of basal dendritic protrusions by EphB2. Kayser MS, et al. PLoS One, 2011 Feb 25. PMID 21364901, Free PMC Article
  5. EphB controls NMDA receptor function and synaptic targeting in a subunit-specific manner. Nolt MJ, et al. J Neurosci, 2011 Apr 6. PMID 21471370, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of EphB2 in the basolateral amygdala is crucial for inducing visceral pain sensitization in rats subjected to water avoidance stress.
    Title: Overexpression of EphB2 in the basolateral amygdala is crucial for inducing visceral pain sensitization in rats subjected to water avoidance stress.
  2. EphB2 knockdown decreases the formation of astroglial-fibrotic scars to promote nerve regeneration after spinal cord injury in rats.
    Title: EphB2 knockdown decreases the formation of astroglial-fibrotic scars to promote nerve regeneration after spinal cord injury in rats.
  3. The ephrin receptor EphB2 regulates the connectivity and activity of enteric neurons.
    Title: The ephrin receptor EphB2 regulates the connectivity and activity of enteric neurons.
  4. Extracellular vesicles derived from EphB2-overexpressing bone marrow mesenchymal stem cells ameliorate DSS-induced colitis by modulating immune balance.
    Title: Extracellular vesicles derived from EphB2-overexpressing bone marrow mesenchymal stem cells ameliorate DSS-induced colitis by modulating immune balance.
  5. Study identified a RhoA guanine nucleotide exchange factor, Ephexin5, which negatively regulates excitatory synapse development until EphrinB binding to the EphB receptor triggers Ephexin5 phosphorylation, ubiquitination, and degradation.
    Title: EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation.
  6. EphB2 regulates the actions of filopodia through a combination of precise subcellular localization and induction of specific intracellular signals within filopodia. Simple differences in the kinetics of EphB kinase signaling at the tips of filopodia mediate the choice between retraction and synaptogenesis.
    Title: Filopodia Conduct Target Selection in Cortical Neurons Using Differences in Signal Kinetics of a Single Kinase.
  7. Results show that EphB2 acts downstream of Ascl1, its direct target, in regulating tangential migration.
    Title: Ascl1 promotes tangential migration and confines migratory routes by induction of Ephb2 in the telencephalon.
  8. Overexpression of EphB2 also rescued the ADDLs-induced depletion of the expression of EphB2 and GluN2B-containing NMDA receptors trafficking in cultured hippocampal neurons.
    Title: Overexpression of EphB2 in hippocampus rescues impaired NMDA receptors trafficking and cognitive dysfunction in Alzheimer model.
  9. we revealed that stimulation with the extracellular domain of EphB2 to activate Eph/ephrin reverse signalling induced axonal retraction in hippocampal neurons.
    Title: Eph/ephrin reverse signalling induces axonal retraction through RhoA/ROCK pathway.
  10. elevated GluA2 trafficking induced by activated EphB2/ephrinB2 reverse signaling likely contributes to Retinal Ganglion Cell apoptosis in Chronic Ocular Hypertension rats.
    Title: GluA2 trafficking is involved in apoptosis of retinal ganglion cells induced by activation of EphB/EphrinB reverse signaling in a rat chronic ocular hypertension model.
Submit: New GeneRIF Correction See all GeneRIFs (17)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
ephrin type-B receptor 2
Names
ephrin type-B receptor 2-like
NP_001120791.2
XP_038965983.1
XP_038965984.1
XP_038965985.1
XP_038965986.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127319.4 → NP_001120791.2  ephrin type-B receptor 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    B2B9B0
    Conserved Domains (5) summary
    cd05065
    Location:616 → 884
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:910 → 980
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:19 → 196
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:437 → 520
    fn3; Fibronectin type III domain
    pfam14575
    Location:567 → 617
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    154179065..154360459 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110058.2 → XP_038965986.1  ephrin type-B receptor 2 isoform X4

    UniProtKB/TrEMBL
    B2B9B0
    Conserved Domains (5) summary
    cd05065
    Location:586 → 854
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:880 → 950
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:19 → 196
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:326 → 421
    fn3; Fibronectin type III domain
    pfam14575
    Location:534 → 587
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

  2. XM_039110055.2 → XP_038965983.1  ephrin type-B receptor 2 isoform X1

    UniProtKB/TrEMBL
    B2B9B0
    Related
    ENSRNOP00000016983.8, ENSRNOT00000016983.9
    Conserved Domains (5) summary
    cd05065
    Location:618 → 886
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:912 → 982
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:19 → 196
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:437 → 521
    fn3; Fibronectin type III domain
    pfam14575
    Location:566 → 619
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

  3. XM_039110057.2 → XP_038965985.1  ephrin type-B receptor 2 isoform X3

    UniProtKB/TrEMBL
    B2B9B0
    Conserved Domains (5) summary
    cd05065
    Location:617 → 885
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:911 → 981
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:19 → 196
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:437 → 520
    fn3; Fibronectin type III domain
    pfam14575
    Location:565 → 618
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

  4. XM_039110056.2 → XP_038965984.1  ephrin type-B receptor 2 isoform X2

    UniProtKB/TrEMBL
    B2B9B0
    Conserved Domains (5) summary
    cd05065
    Location:617 → 885
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:911 → 981
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:19 → 196
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:437 → 521
    fn3; Fibronectin type III domain
    pfam14575
    Location:568 → 618
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RNA

  1. XR_010066401.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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