These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
-
NM_001159995.3 → NP_001153467.1 pro-neuregulin-1, membrane-bound isoform isoform HRG-beta1c
Status: REVIEWED
- Description
- Transcript Variant: This variant (HRG-beta1c), which uses the type IV promoter, contains an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region, and it also lacks an in-frame exon in the central coding region, compared to variant HRG-beta1. The resulting isoform (HRG-beta1c, also known as type IV fetal C beta 1a or fetal b IV-beta 1a) has a distinct N-terminus, lacks an internal segment, and is shorter than isoform HRG-beta1.
- Source sequence(s)
-
AC113209, CA429204, DA805080, EF517297, GQ983557, M94166
- Consensus CDS
-
CCDS94272.1
- UniProtKB/Swiss-Prot
-
Q02297
- UniProtKB/TrEMBL
- A0A494C1F8, A6MW56, E3SFM9
- Related
- ENSP00000499008.1, ENST00000652698.1
- Conserved Domains (4) summary
-
- cd05895
Location:32 → 106
- Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
- smart00410
Location:22 → 108
- IG_like; Immunoglobulin like
- pfam00008
Location:152 → 182
- EGF; EGF-like domain
- pfam02158
Location:202 → 595
- Neuregulin; Neuregulin family
-
NM_001159996.3 → NP_001153468.1 pro-neuregulin-1, membrane-bound isoform isoform ndf43c
See identical proteins and their annotated locations for NP_001153468.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (ndf43c), which uses the type VI promoter, lacks multiple 5' exons but contains an alternate 5' terminal exon, and it also lacks two in-frame exons in the central coding region and includes an additional exon that results in an alternate 3' coding region, compared to variant HRG-beta1. The resulting isoform (ndf43c, also known as ndf43) has distinct N- and C-termini, lacks an internal segment, and is shorter than isoform HRG-beta1.
- Source sequence(s)
-
AC113209, AK293240, BC144446, CA429204, DA805080, DC425692
- Consensus CDS
-
CCDS75727.1
- UniProtKB/TrEMBL
- B7Z1D7, E5RHP6, F6RJN6
- Related
- ENSP00000430862.2, ENST00000522402.6
- Conserved Domains (3) summary
-
- PHA03099
Location:28 → 120
- PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
- cd00054
Location:36 → 68
- EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
- pfam02158
Location:113 → 270
- Neuregulin; Neuregulin family
-
NM_001159999.3 → NP_001153471.1 pro-neuregulin-1, membrane-bound isoform isoform HRG-beta1b
Status: REVIEWED
- Description
- Transcript Variant: This variant (HRG-beta1b), which uses the type IV promoter, contains an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region, compared to variant HRG-beta1. The resulting isoform (HRG-beta1b, also known as type IV fetal B beta 1a) has a distinct N-terminus and is shorter than isoform HRG-beta1.
- Source sequence(s)
-
AC113209, CA429204, CN603652, DA805080, EF517296, GQ983557, M94165, U02328
- Consensus CDS
-
CCDS94271.1
- UniProtKB/Swiss-Prot
-
Q02297
- UniProtKB/TrEMBL
- A0A494C1F5, A6MW55, E3SFM9
- Related
- ENSP00000499045.1, ENST00000650866.1
- Conserved Domains (4) summary
-
- cd05895
Location:32 → 106
- Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
- smart00410
Location:22 → 108
- IG_like; Immunoglobulin like
- pfam00008
Location:169 → 199
- EGF; EGF-like domain
- pfam02158
Location:219 → 612
- Neuregulin; Neuregulin family
-
NM_001160001.3 → NP_001153473.1 pro-neuregulin-1, membrane-bound isoform isoform HRG-beta1d
Status: REVIEWED
- Description
- Transcript Variant: This variant (HRG-beta1d), which uses the type IV promoter, contains an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region, and it also lacks two in-frame exons in the central coding region, compared to variant HRG-beta1. The resulting isoform (HRG-beta1d, also known as IV-beta 1a or type IV fetal A beta 1a) has a distinct N-terminus, lacks an internal segment, and is shorter than isoform HRG-beta1.
- Source sequence(s)
-
AC113209, CA429204, CN603654, DA805080, EF372273, GQ983557, M94165
- Consensus CDS
-
CCDS55218.1
- UniProtKB/Swiss-Prot
-
Q02297
- UniProtKB/TrEMBL
-
E3SFM9
- Related
- ENSP00000429582.1, ENST00000519301.6
- Conserved Domains (4) summary
-
- cd05895
Location:32 → 106
- Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
- smart00410
Location:22 → 108
- IG_like; Immunoglobulin like
- pfam00008
Location:135 → 165
- EGF; EGF-like domain
- pfam02158
Location:185 → 578
- Neuregulin; Neuregulin family
-
NM_001160002.2 → NP_001153474.1 pro-neuregulin-1, membrane-bound isoform isoform HRG-gamma2
Status: REVIEWED
- Description
- Transcript Variant: This variant (HRG-gamma2), which uses the type I promoter, lacks an internal in-frame exon and multiple 3' exons, but contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant HRG-beta1. The resulting isoform (HRG-gamma2, also known as gamma protein isoform 1) lacks an internal segment, has a distinct C-terminus, and is shorter than isoform HRG-beta1.
- Source sequence(s)
-
AC083977, AC103675, EU363508
- UniProtKB/TrEMBL
-
B0FYA7
- Conserved Domains (2) summary
-
- smart00410
Location:43 → 129
- IG_like; Immunoglobulin like
- cl11960
Location:53 → 127
- Ig; Immunoglobulin domain
-
NM_001160004.3 → NP_001153476.1 pro-neuregulin-1, membrane-bound isoform isoform ndf43b
See identical proteins and their annotated locations for NP_001153476.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (ndf43b), which uses the type I promoter, lacks an alternate in-frame exon in the central coding region, and contains an additional exon that results in an alternate 3' coding region, compared to variant HRG-beta1. The resulting isoform (ndf43b, also known as ndf43-beta2) lacks an internal segment, has a distinct C-terminus, and is shorter than isoform HRG-beta1.
- Source sequence(s)
-
AC083977, AC113209, BC144446, CA429204, DA805080, EU363510
- Consensus CDS
-
CCDS94273.1
- UniProtKB/TrEMBL
- A0A494C0K4, B0FYA9
- Related
- ENSP00000498583.1, ENST00000650980.1
- Conserved Domains (3) summary
-
- cd05895
Location:53 → 127
- Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
- pfam02158
Location:232 → 421
- Neuregulin; Neuregulin family
- cl28647
Location:182 → 271
- PHA02887; EGF-like protein; Provisional
-
NM_001160005.2 → NP_001153477.1 pro-neuregulin-1, membrane-bound isoform isoform HRG-beta3b
See identical proteins and their annotated locations for NP_001153477.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (HRG-beta3b), which uses the type I promoter, lacks two internal in-frame exons and multiple 3' exons, but contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant HRG-beta1. The resulting isoform (HRG-beta3b, also known as HRG-beta 3 protein isoform) lacks an internal segment, has a distinct C-terminus, and is shorter than isoform HRG-beta1.
- Source sequence(s)
-
AC083977, EU359055, M94168
- Consensus CDS
-
CCDS94275.1
- UniProtKB/Swiss-Prot
-
Q02297
- UniProtKB/TrEMBL
- A0A494C114, B0FWZ3
- Related
- ENSP00000498833.1, ENST00000650967.1
- Conserved Domains (2) summary
-
- smart00410
Location:43 → 129
- IG_like; Immunoglobulin like
- cl11960
Location:53 → 127
- Ig; Immunoglobulin domain
-
NM_001160007.2 → NP_001153479.1 pro-neuregulin-1, membrane-bound isoform isoform HRG-gamma3
Status: REVIEWED
- Description
- Transcript Variant: This variant (HRG-gamma3), which uses the type I promoter, lacks two internal in-frame exons and multiple 3' exons, but contains an alternate 3' terminal exon that results in an early stop codon and an alternate 3' UTR, compared to variant HRG-beta1. The resulting isoform (HRG-gamma3, also known as gamma protein isoform 2) lacks an internal segment and is shorter at the C-terminus, compared to isoform HRG-beta1.
- Source sequence(s)
-
AC083977, AC103675, EU363509
- UniProtKB/TrEMBL
-
B0FYA8
- Conserved Domains (2) summary
-
- cd00096
Location:37 → 43
- Ig; putative Ig strand A [structural motif]
- cl11960
Location:37 → 129
- Ig; Immunoglobulin domain
-
NM_001160008.2 → NP_001153480.1 pro-neuregulin-1, membrane-bound isoform isoform HRG-beta2b
Status: REVIEWED
- Description
- Transcript Variant: This variant (HRG-beta2b), which uses the type I promoter, lacks an alternate in-frame exon in the central coding region, and it also contains alternate 3' exon structure resulting an in early stop codon and alternate 3' UTR, compared to variant HRG-beta1. The resulting isoform (HRG-beta2b) lacks an internal segment and is shorter at the C-terminus, compared to isoform HRG-beta1.
- Source sequence(s)
-
AC113209, AK097005, AK298132, BC006492, BQ018711
- Consensus CDS
-
CCDS55219.1
- UniProtKB/Swiss-Prot
-
Q02297
- UniProtKB/TrEMBL
- B0FYA9, Q6PK61
- Related
- ENSP00000430120.1, ENST00000523079.5
- Conserved Domains (3) summary
-
- cd05895
Location:53 → 127
- Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
- pfam02158
Location:232 → 420
- Neuregulin; Neuregulin family
- cl28647
Location:182 → 271
- PHA02887; EGF-like protein; Provisional
-
NM_001322197.2 → NP_001309126.1 pro-neuregulin-1, membrane-bound isoform isoform VI-1
Status: REVIEWED
- Description
- Transcript Variant: This variant (VI-1), which uses the type VI promoter, lacks multiple 5' exons but contains an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region, and it also lacks an in-frame exon in the central coding region, compared to variant HRG-beta1. The resulting isoform (VI-1) has a distinct N-terminus, lacks an internal segment, and is shorter than isoform HRG-beta1.
- Source sequence(s)
-
AC113209, AK293270, CA429204, CN603661
- UniProtKB/TrEMBL
- B7Z1E3, E3SFM9
- Conserved Domains (2) summary
-
- PHA03099
Location:28 → 117
- PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
- pfam02158
Location:78 → 471
- Neuregulin; Neuregulin family
-
NM_001322201.2 → NP_001309130.1 pro-neuregulin-1, membrane-bound isoform isoform a
Status: REVIEWED
- Description
- Transcript Variant: This variant (fetal-a-IV-1), which uses the type IV promoter, contains an alternate 5' terminal exon and lacks three internal exons, and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant HRG-beta1. The resulting isoform (a) is shorter at the N-terminus, compared to isoform HRG-beta1. Both variants fetal-a-IV-1 and fetal-c-IV-2 encode isoform a.
- Source sequence(s)
-
AC083977, AC103675, AC113209, CA429204, EF372275, GQ983557
- UniProtKB/TrEMBL
- A5YAK6, E3SFM9
- Conserved Domains (1) summary
-
- pfam02158
Location:1 → 370
- Neuregulin; Neuregulin family
-
NM_001322202.2 → NP_001309131.1 pro-neuregulin-1, membrane-bound isoform isoform a
Status: REVIEWED
- Description
- Transcript Variant: This variant (fetal-c-IV-2), which uses the type IV promoter, contains an alternate 5' terminal exon and lacks four internal exons, and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The resulting isoform (a) is shorter at the N-terminus, compared to isoform HRG-beta1. Both variants fetal-a-IV-1 and fetal-c-IV-2 encode isoform a.
- Source sequence(s)
-
AC103675, AC113209, CA429204, EF372277, GQ983557
- UniProtKB/TrEMBL
- A5YAK8, E3SFM9
- Conserved Domains (1) summary
-
- pfam02158
Location:1 → 370
- Neuregulin; Neuregulin family
-
NM_001322205.2 → NP_001309134.1 pro-neuregulin-1, membrane-bound isoform isoform NRG-III-beta1a
Status: REVIEWED
- Description
- Transcript Variant: This variant (NRG-III-beta1a), which uses the type III promoter, lacks several 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant HRG-beta1. The resulting isoform (NRG-III-beta1a, also known as nARIAbeta1a or CRD-NRGbeta1a) has a distinct N-terminus and is longer than isoform HRG-beta1.
- Source sequence(s)
-
AC103675, AC113209, AK289927, CA429204, EF517295
- Consensus CDS
-
CCDS94277.1
- UniProtKB/Swiss-Prot
-
Q02297
- UniProtKB/TrEMBL
- A0A494C0Q4, A6MW54
- Related
- ENSP00000498646.1, ENST00000652592.1
- Conserved Domains (2) summary
-
- PHA02887
Location:236 → 279
- PHA02887; EGF-like protein; Provisional
- pfam02158
Location:295 → 688
- Neuregulin; Neuregulin family
-
NM_001322206.2 → NP_001309135.1 pro-neuregulin-1, membrane-bound isoform isoform III-2
Status: REVIEWED
- Description
- Transcript Variant: This variant (III-2), which uses the type III promoter, lacks several 5' exons but contains an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region, and it also includes an additional exon that results in an alternate 3' coding region, compared to variant HRG-beta1. The resulting isoform (III-2) has distinct N- and C-termini and is shorter than isoform HRG-beta1.
- Source sequence(s)
-
AC113209, AK289927, BC144446, CA429204, M94166
- Consensus CDS
-
CCDS94276.1
- UniProtKB/Swiss-Prot
-
Q02297
- UniProtKB/TrEMBL
-
A0A494C0L9
- Related
- ENSP00000498590.1, ENST00000651333.2
- Conserved Domains (2) summary
-
- PHA02887
Location:236 → 279
- PHA02887; EGF-like protein; Provisional
- pfam02158
Location:295 → 484
- Neuregulin; Neuregulin family
-
NM_001322207.2 → NP_001309136.1 pro-neuregulin-1, membrane-bound isoform isoform III-3
Status: REVIEWED
- Description
- Transcript Variant: This variant (III-3), which uses the type III promoter, lacks several 5' exons but contains an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region, and it also contains an alternate 3' terminal exon that results in an early stop codon, compared to variant HRG-beta1. The resulting isoform (III-3) has distinct N- and C-termini and is shorter than isoform HRG-beta1.
- Source sequence(s)
-
AC113209, AK289927, AK298132, BC144446, BQ018711, M94166
- Consensus CDS
-
CCDS94278.1
- UniProtKB/Swiss-Prot
-
Q02297
- UniProtKB/TrEMBL
-
A0A494C1B5
- Related
- ENSP00000498946.1, ENST00000650819.1
- Conserved Domains (2) summary
-
- PHA02887
Location:236 → 279
- PHA02887; EGF-like protein; Provisional
- pfam02158
Location:295 → 483
- Neuregulin; Neuregulin family
-
NM_004495.4 → NP_004486.2 pro-neuregulin-1, membrane-bound isoform isoform HRG-gamma
See identical proteins and their annotated locations for NP_004486.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (HRG-gamma), which uses the type I promoter, lacks multiple 3' exons but contains an alternate 3' terminal exon that results in an early stop codon, compared to variant HRG-beta1. The resulting isoform (HRG-gamma) is shorter at the C-terminus, compared to isoform HRG-beta1.
- Source sequence(s)
-
AC083977, AC103675, BC144446
- UniProtKB/TrEMBL
- B5BU95, Q7RTW5
- Related
-
ENST00000651807.1
- Conserved Domains (2) summary
-
- smart00410
Location:43 → 129
- IG_like; Immunoglobulin like
- cl11960
Location:53 → 127
- Ig; Immunoglobulin domain
-
NM_013956.5 → NP_039250.2 pro-neuregulin-1, membrane-bound isoform isoform HRG-beta1
See identical proteins and their annotated locations for NP_039250.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (HRG-beta1), which uses the type I promoter, encodes isoform HRG-beta1 (also known as NDF-beta1a or HRG-beta1a).
- Source sequence(s)
-
AC113209, AK097005, AK298132, BC006492, BC144446, CA429204, DA805080, M94166
- Consensus CDS
-
CCDS6083.1
- UniProtKB/Swiss-Prot
-
Q02297
- UniProtKB/TrEMBL
- Q6PK61, Q7RTW4
- Related
- ENSP00000287842.4, ENST00000287842.7
- Conserved Domains (4) summary
-
- cd05895
Location:53 → 127
- Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
- smart00410
Location:43 → 129
- IG_like; Immunoglobulin like
- pfam00008
Location:190 → 220
- EGF; EGF-like domain
- pfam02158
Location:240 → 633
- Neuregulin; Neuregulin family
-
NM_013957.5 → NP_039251.2 pro-neuregulin-1, membrane-bound isoform isoform HRG-beta2
See identical proteins and their annotated locations for NP_039251.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (HRG-beta2), which uses the type I promoter, lacks an alternate in-frame exon in the central coding region, compared to variant HRG-beta1, resulting in an isoform (HRG-beta2) that is shorter than isoform HRG-beta1.
- Source sequence(s)
-
AC113209, AK097005, AK290730, AK298132, BC006492, CA429204, DA805080, M94165
- Consensus CDS
-
CCDS6084.1
- UniProtKB/Swiss-Prot
-
Q02297
- UniProtKB/TrEMBL
- Q6PK61, Q7RTW3
- Related
- ENSP00000349275.6, ENST00000356819.7
- Conserved Domains (3) summary
-
- PHA03099
Location:182 → 271
- PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
- smart00409
Location:43 → 129
- IG; Immunoglobulin
- cd00054
Location:190 → 222
- EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
-
NM_013958.4 → NP_039252.2 pro-neuregulin-1, membrane-bound isoform isoform HRG-beta3
See identical proteins and their annotated locations for NP_039252.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (HRG-beta3), which uses the type I promoter, lacks multiple 3' exons but contains an alternate 3' terminal exon that results in an early stop codon, compared to variant HRG-beta1. The resulting isoform (HRG-beta3, also known as GGF or GGFHFB1) is shorter at the C-terminus, compared to isoform HRG-beta1.
- Source sequence(s)
-
AK097005, AK298132, M94165, M94168
- Consensus CDS
-
CCDS94274.1
- UniProtKB/Swiss-Prot
-
Q02297
- UniProtKB/TrEMBL
- A0A024QY88, Q6PK61
- Related
- ENSP00000498811.1, ENST00000650919.1
- Conserved Domains (3) summary
-
- smart00410
Location:43 → 129
- IG_like; Immunoglobulin like
- pfam00008
Location:190 → 220
- EGF; EGF-like domain
- cl11960
Location:53 → 127
- Ig; Immunoglobulin domain
-
NM_013959.4 → NP_039253.1 pro-neuregulin-1, membrane-bound isoform isoform SMDF
See identical proteins and their annotated locations for NP_039253.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (SMDF), which uses the type III promoter, is expressed mainly in the nervous system. It lacks multiple 5' and 3' exons but has alternate 5' and 3' terminal exons, and it thus differs in the 5' and 3' coding regions and in both UTRs, compared to variant HRG-beta1. The resulting isoform (SMDF, also known as NRG-III-beta3) has distinct N- and C-termini and is shorter than isoform HRG-beta1.
- Source sequence(s)
-
AK289927, M94168
- Consensus CDS
-
CCDS6087.1
- UniProtKB/Swiss-Prot
-
Q02297
- UniProtKB/TrEMBL
- Q53F54, Q6ICV5, Q96IB3
- Related
- ENSP00000433289.1, ENST00000520502.7
- Conserved Domains (1) summary
-
- PHA02887
Location:236 → 279
- PHA02887; EGF-like protein; Provisional
-
NM_013960.5 → NP_039254.1 pro-neuregulin-1, membrane-bound isoform isoform ndf43 proprotein
See identical proteins and their annotated locations for NP_039254.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (ndf43), which uses the type I promoter, lacks two in-frame exons but contains a different in-frame exon in the central coding region, and it also contains an additional exon that results in an alternate 3' coding region, compared to variant HRG-beta1. The resulting isoform (ndf43) has an alternate internal segment and a distinct C-terminus, and is shorter than isoform HRG-beta1.
- Source sequence(s)
-
AC113209, AK097005, AK298132, BC006492, CA429204, DA805080, M94165, U02326
- Consensus CDS
-
CCDS6086.1
- UniProtKB/Swiss-Prot
-
Q02297
- UniProtKB/TrEMBL
- B0FYA9, Q6PK61
- Related
- ENSP00000428828.1, ENST00000521670.5
- Conserved Domains (3) summary
-
- cd05895
Location:53 → 127
- Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
- pfam00008
Location:190 → 220
- EGF; EGF-like domain
- pfam02158
Location:235 → 424
- Neuregulin; Neuregulin family
-
NM_013962.3 → NP_039256.2 pro-neuregulin-1, membrane-bound isoform isoform GGF2 precursor
See identical proteins and their annotated locations for NP_039256.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (GGF2), which uses the type II promoter, is expressed in the nervous system and functions as a neuronal signal that promotes the proliferation and survival of the oligodendrocyte and the myelinating cell. This variant contains alternate 5' and 3' terminal exons and thus differs in the 5' and 3' coding regions and in both UTRs, and it also lacks two alternate in-frame exons in the central coding region, compared to variant HRG-beta1. The resulting isoform (GGF2, also known as GGFHBS5) has distinct N- and C-termini, lacks an internal segment, and is shorter than isoform HRG-beta1.
- Source sequence(s)
-
AC104000, L12260, M94165, M94168
- Consensus CDS
-
CCDS47836.1
- UniProtKB/Swiss-Prot
-
Q02297
- Related
- ENSP00000434640.1, ENST00000520407.5
- Conserved Domains (2) summary
-
- cd05895
Location:268 → 342
- Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
- cl28647
Location:362 → 405
- PHA02887; EGF-like protein; Provisional
-
NM_013964.5 → NP_039258.1 pro-neuregulin-1, membrane-bound isoform isoform HRG-alpha proprotein
See identical proteins and their annotated locations for NP_039258.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (HRG-alpha), which uses the type I promoter, lacks two in-frame exons but contains a different in-frame exon in the central coding region, compared to variant HRG-beta1. The resulting isoform (HRG-alpha, also known as erbB2 or gp30/alpha 1) contains an alternate internal segment and is shorter than isoform HRG-beta1.
- Source sequence(s)
-
AC113209, AK097005, AK298132, BC006492, CA429204, DA805080, M94165
- Consensus CDS
-
CCDS6085.1
- UniProtKB/Swiss-Prot
- A5YAK4, A5YAK5, A8K1L2, B7Z4Z3, E9PHH4, O14667, P98202, Q02297, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q15491, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3
- UniProtKB/TrEMBL
- Q6PK61, Q7RTV8
- Related
- ENSP00000384620.2, ENST00000405005.8
- Conserved Domains (4) summary
-
- cd05895
Location:53 → 127
- Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
- smart00410
Location:43 → 129
- IG_like; Immunoglobulin like
- pfam00008
Location:190 → 220
- EGF; EGF-like domain
- pfam02158
Location:235 → 628
- Neuregulin; Neuregulin family