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Nrg1 neuregulin 1 [ Mus musculus (house mouse) ]

Gene ID: 211323, updated on 8-Feb-2024

Summary

Official Symbol
Nrg1provided by MGI
Official Full Name
neuregulin 1provided by MGI
Primary source
MGI:MGI:96083
See related
Ensembl:ENSMUSG00000062991 AllianceGenome:MGI:96083
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GGF; HRG; Hgl; NDF; ARIA; SMDF; GGFII; HRGalpha; Pro-NRG1; 6030402G23Rik; D230005F13Rik
Summary
Enables ErbB-2 class receptor binding activity and chemorepellent activity. Involved in several processes, including positive regulation of cardiac muscle cell differentiation; postsynapse to nucleus signaling pathway; and synapse assembly. Acts upstream of or within several processes, including neurogenesis; positive regulation of intracellular signal transduction; and positive regulation of macromolecule metabolic process. Located in several cellular components, including axolemma; external side of plasma membrane; and neuromuscular junction. Is integral component of plasma membrane. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in several diseases, including bipolar disorder; cerebral malaria; dementia; middle cerebral artery infarction; and psychotic disorder (multiple). Orthologous to human NRG1 (neuregulin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 2.0), CNS E14 (RPKM 1.9) and 17 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See Nrg1 in Genome Data Viewer
Location:
8 A3; 8 18.75 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (32299493..33381858, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (31807452..32891609, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21082 Neighboring gene STARR-seq mESC enhancer starr_21083 Neighboring gene predicted gene, 38572 Neighboring gene STARR-seq mESC enhancer starr_21084 Neighboring gene STARR-seq mESC enhancer starr_21085 Neighboring gene STARR-seq mESC enhancer starr_21086 Neighboring gene STARR-seq mESC enhancer starr_21087 Neighboring gene trimethylguanosine synthase homolog pseudogene Neighboring gene VISTA enhancer mm151 Neighboring gene predicted gene, 33223 Neighboring gene STARR-seq mESC enhancer starr_21088 Neighboring gene STARR-seq mESC enhancer starr_21089 Neighboring gene predicted gene, 26578 Neighboring gene STARR-seq mESC enhancer starr_21090 Neighboring gene STARR-seq mESC enhancer starr_21091 Neighboring gene predicted gene 8179 Neighboring gene STARR-seq mESC enhancer starr_21092 Neighboring gene predicted gene, 22140 Neighboring gene predicted gene, 53413 Neighboring gene STARR-seq mESC enhancer starr_21093 Neighboring gene 60S ribosomal protein L27a pseudogene Neighboring gene STARR-seq mESC enhancer starr_21095 Neighboring gene STARR-seq mESC enhancer starr_21096 Neighboring gene STARR-seq mESC enhancer starr_21097 Neighboring gene predicted gene, 39155 Neighboring gene predicted gene, 33082 Neighboring gene predicted gene 3985 Neighboring gene STARR-seq mESC enhancer starr_21098 Neighboring gene predicted gene, 39156 Neighboring gene predicted gene, 33281

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ErbB-2 class receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ErbB-2 class receptor binding IGI
Inferred from Genetic Interaction
more info
PubMed 
enables ErbB-3 class receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables chemorepellent activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chemorepellent activity IDA
Inferred from Direct Assay
more info
PubMed 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
enables receptor ligand activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in ERBB signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in ERBB2-ERBB3 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ERBB2-ERBB3 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ERBB2-ERBB3 signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in ERBB2-ERBB4 signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in ERBB3 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in ERBB4 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ERBB4 signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in ERBB4-ERBB4 signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in Schwann cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within Schwann cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in activation of protein kinase B activity ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in activation of transmembrane receptor protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in animal organ development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cardiac conduction system development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle cell myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac muscle tissue development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chemorepulsion involved in interneuron migration from the subpallium to the cortex IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within detection of temperature stimulus involved in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocardial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glial cell fate commitment IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in memory ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within muscle organ development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myelination in peripheral nervous system IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of corticosterone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron migration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within peripheral nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of Ras protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of Schwann cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of axon regeneration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of calcineurin-NFAT signaling cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of striated muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in postsynapse to nucleus signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in postsynapse to nucleus signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein-containing complex disassembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of presynapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of presynapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sequestering of metal ion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic membrane adhesion EXP
Inferred from Experiment
more info
PubMed 
involved_in synaptic membrane adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic membrane adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic membrane adhesion IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in ventricular cardiac muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in ventricular trabecula myocardium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space IGI
Inferred from Genetic Interaction
more info
PubMed 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mossy fiber rosette EXP
Inferred from Experiment
more info
PubMed 
is_active_in mossy fiber rosette IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mossy fiber rosette IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in mossy fiber rosette IPI
Inferred from Physical Interaction
more info
PubMed 
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pro-neuregulin-1, membrane-bound isoform
Names
heregulin
type I neuregulin 1
type III neuregulin 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364421.2NP_001351350.1  pro-neuregulin-1, membrane-bound isoform isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC127374, AC132407, AC136147
    Consensus CDS
    CCDS90385.1
    UniProtKB/Swiss-Prot
    Q6DR98
    UniProtKB/TrEMBL
    A0A140LJ88
    Related
    ENSMUSP00000146456.2, ENSMUST00000207470.3
    Conserved Domains (3) summary
    cd05895
    Location:53127
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    pfam00008
    Location:190220
    EGF; EGF-like domain
    pfam02158
    Location:240633
    Neuregulin; Neuregulin family
  2. NM_001364422.1NP_001351351.1  pro-neuregulin-1, membrane-bound isoform isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127374, AC132407
    Conserved Domains (1) summary
    pfam02158
    Location:287680
    Neuregulin; Neuregulin family
  3. NM_001364423.1NP_001351352.1  pro-neuregulin-1, membrane-bound isoform isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC127374, AC132407
    Conserved Domains (2) summary
    pfam00008
    Location:245275
    EGF; EGF-like domain
    pfam02158
    Location:353708
    Neuregulin; Neuregulin family
  4. NM_001364424.1NP_001351353.1  pro-neuregulin-1, membrane-bound isoform isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC127374, AC132407
    UniProtKB/TrEMBL
    Q3URY7
    Conserved Domains (1) summary
    pfam02158
    Location:295484
    Neuregulin; Neuregulin family
  5. NM_001364425.1NP_001351354.1  pro-neuregulin-1, membrane-bound isoform isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC127374, AC132407
    Conserved Domains (1) summary
    pfam02158
    Location:75430
    Neuregulin; Neuregulin family
  6. NM_001364426.1NP_001351355.1  pro-neuregulin-1, membrane-bound isoform isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC127374, AC132407
    Consensus CDS
    CCDS90383.1
    UniProtKB/TrEMBL
    A0A140LIG9, Q3URY7
    Related
    ENSMUSP00000146816.2, ENSMUST00000208497.3
    Conserved Domains (1) summary
    pfam02158
    Location:295483
    Neuregulin; Neuregulin family
  7. NM_001364427.1NP_001351356.1  pro-neuregulin-1, membrane-bound isoform isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC127374, AC132407
    UniProtKB/TrEMBL
    Q3URY7
    Conserved Domains (1) summary
    pfam02158
    Location:321510
    Neuregulin; Neuregulin family
  8. NM_001364428.1NP_001351357.1  pro-neuregulin-1, membrane-bound isoform isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC127374, AC132407
    UniProtKB/TrEMBL
    Q3URY7
    Conserved Domains (1) summary
    pfam02158
    Location:287476
    Neuregulin; Neuregulin family
  9. NM_001364429.1NP_001351358.1  pro-neuregulin-1, membrane-bound isoform isoform 10 precursor

    Status: VALIDATED

    Source sequence(s)
    AC127374, AC132407
    UniProtKB/TrEMBL
    Q3TD94
    Related
    ENSMUSP00000159071.2, ENSMUST00000207678.3
    Conserved Domains (2) summary
    pfam00008
    Location:78108
    EGF; EGF-like domain
    pfam02158
    Location:123311
    Neuregulin; Neuregulin family
  10. NM_001364430.1NP_001351359.1  pro-neuregulin-1, membrane-bound isoform isoform 11 precursor

    Status: VALIDATED

    Source sequence(s)
    AC132407
  11. NM_001364431.1NP_001351360.1  pro-neuregulin-1, membrane-bound isoform isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC132407, AK048708
    Consensus CDS
    CCDS90382.1
    UniProtKB/TrEMBL
    A0A5F8MPT0, Q8BX76
    Related
    ENSMUSP00000159096.2, ENSMUST00000238812.2
    Conserved Domains (1) summary
    cl28647
    Location:236279
    PHA02887; EGF-like protein; Provisional
  12. NM_178591.3NP_848706.2  pro-neuregulin-1, membrane-bound isoform isoform 1

    See identical proteins and their annotated locations for NP_848706.2

    Status: VALIDATED

    Source sequence(s)
    AC127374, AC132407, AK141037, AY648975, BY238526
    Consensus CDS
    CCDS40315.1
    UniProtKB/TrEMBL
    Q6DR99
    Related
    ENSMUSP00000073546.5, ENSMUST00000073884.7
    Conserved Domains (2) summary
    PHA02887
    Location:236279
    PHA02887; EGF-like protein; Provisional
    pfam02158
    Location:295688
    Neuregulin; Neuregulin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    32299493..33381858 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509068.5XP_006509131.1  pro-neuregulin-1, membrane-bound isoform isoform X10

    Conserved Domains (4) summary
    cd05895
    Location:266340
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    PHA03099
    Location:361450
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    pfam00008
    Location:369399
    EGF; EGF-like domain
    pfam02158
    Location:443798
    Neuregulin; Neuregulin family
  2. XM_006509067.5XP_006509130.1  pro-neuregulin-1, membrane-bound isoform isoform X9

    Conserved Domains (3) summary
    cd05895
    Location:266340
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    pfam00008
    Location:369399
    EGF; EGF-like domain
    pfam02158
    Location:451806
    Neuregulin; Neuregulin family
  3. XM_006509065.5XP_006509128.1  pro-neuregulin-1, membrane-bound isoform isoform X7

    Conserved Domains (3) summary
    cd05895
    Location:266340
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    pfam00008
    Location:369399
    EGF; EGF-like domain
    pfam02158
    Location:477832
    Neuregulin; Neuregulin family
  4. XM_006509066.5XP_006509129.1  pro-neuregulin-1, membrane-bound isoform isoform X8

    Conserved Domains (3) summary
    cd05895
    Location:266340
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    pfam00008
    Location:386416
    EGF; EGF-like domain
    pfam02158
    Location:468823
    Neuregulin; Neuregulin family
  5. XM_006509061.5XP_006509124.1  pro-neuregulin-1, membrane-bound isoform isoform X3

    Conserved Domains (3) summary
    cd05895
    Location:266340
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    pfam00008
    Location:386416
    EGF; EGF-like domain
    pfam02158
    Location:494849
    Neuregulin; Neuregulin family
  6. XM_006509064.5XP_006509127.1  pro-neuregulin-1, membrane-bound isoform isoform X6

    Conserved Domains (4) summary
    cd05895
    Location:266340
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    PHA03099
    Location:395484
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    pfam00008
    Location:403433
    EGF; EGF-like domain
    pfam02158
    Location:477832
    Neuregulin; Neuregulin family
  7. XM_006509062.5XP_006509125.1  pro-neuregulin-1, membrane-bound isoform isoform X4

    UniProtKB/TrEMBL
    A0A140LHZ9
    Related
    ENSMUSP00000146617.3, ENSMUST00000209107.4
    Conserved Domains (3) summary
    cd05895
    Location:266340
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    pfam00008
    Location:403433
    EGF; EGF-like domain
    pfam02158
    Location:485840
    Neuregulin; Neuregulin family
  8. XM_006509060.5XP_006509123.1  pro-neuregulin-1, membrane-bound isoform isoform X2

    Conserved Domains (3) summary
    cd05895
    Location:266340
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    pfam00008
    Location:403433
    EGF; EGF-like domain
    pfam02158
    Location:503858
    Neuregulin; Neuregulin family
  9. XM_006509059.5XP_006509122.1  pro-neuregulin-1, membrane-bound isoform isoform X1

    Conserved Domains (3) summary
    cd05895
    Location:266340
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    pfam00008
    Location:403433
    EGF; EGF-like domain
    pfam02158
    Location:511866
    Neuregulin; Neuregulin family
  10. XM_006509063.5XP_006509126.1  pro-neuregulin-1, membrane-bound isoform isoform X5

    Conserved Domains (3) summary
    cd05895
    Location:266340
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    pfam00008
    Location:403433
    EGF; EGF-like domain
    pfam02158
    Location:480835
    Neuregulin; Neuregulin family
  11. XM_030243394.1XP_030099254.1  pro-neuregulin-1, membrane-bound isoform isoform X18

    UniProtKB/TrEMBL
    A0A5F8MPJ0
    Conserved Domains (3) summary
    cd05895
    Location:53127
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    pfam00008
    Location:156186
    EGF; EGF-like domain
    pfam02158
    Location:264619
    Neuregulin; Neuregulin family
  12. XM_030243393.2XP_030099253.1  pro-neuregulin-1, membrane-bound isoform isoform X16

    UniProtKB/TrEMBL
    A0A140LJ88, A0A140LJC1
    Related
    ENSMUSP00000147156.2, ENSMUST00000208205.3
    Conserved Domains (4) summary
    cd05895
    Location:53127
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    PHA03099
    Location:182274
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    pfam00008
    Location:190220
    EGF; EGF-like domain
    pfam02158
    Location:267622
    Neuregulin; Neuregulin family
  13. XM_006509078.5XP_006509141.1  pro-neuregulin-1, membrane-bound isoform isoform X15

    UniProtKB/TrEMBL
    A0A140LJ88
    Related
    ENSMUSP00000147121.2, ENSMUST00000208488.2
    Conserved Domains (3) summary
    cd05895
    Location:53127
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    pfam00008
    Location:190220
    EGF; EGF-like domain
    pfam02158
    Location:298653
    Neuregulin; Neuregulin family
  14. XM_036153857.1XP_036009750.1  pro-neuregulin-1, membrane-bound isoform isoform X17

    UniProtKB/TrEMBL
    A0A140LIP8, A0A140LJ88
    Related
    ENSMUSP00000146905.2, ENSMUST00000207417.3
    Conserved Domains (4) summary
    PHA03099
    Location:182271
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    pfam00008
    Location:190220
    EGF; EGF-like domain
    pfam02158
    Location:264619
    Neuregulin; Neuregulin family
    cd05895
    Location:37129
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
  15. XM_006509072.4XP_006509135.1  pro-neuregulin-1, membrane-bound isoform isoform X12

    UniProtKB/TrEMBL
    A0A5F8MPT8
    Related
    ENSMUSP00000159112.2, ENSMUST00000238842.2
    Conserved Domains (2) summary
    pfam00008
    Location:245275
    EGF; EGF-like domain
    pfam02158
    Location:322677
    Neuregulin; Neuregulin family
  16. XM_036153856.1XP_036009749.1  pro-neuregulin-1, membrane-bound isoform isoform X11

    Conserved Domains (2) summary
    pfam00008
    Location:245275
    EGF; EGF-like domain
    pfam02158
    Location:353708
    Neuregulin; Neuregulin family
  17. XM_036153858.1XP_036009751.1  pro-neuregulin-1, membrane-bound isoform isoform X23

    Conserved Domains (1) summary
    pfam02158
    Location:9364
    Neuregulin; Neuregulin family
  18. XM_036153859.1XP_036009752.1  pro-neuregulin-1, membrane-bound isoform isoform X23

    Conserved Domains (1) summary
    pfam02158
    Location:9364
    Neuregulin; Neuregulin family
  19. XM_017312640.3XP_017168129.1  pro-neuregulin-1, membrane-bound isoform isoform X20

    Conserved Domains (1) summary
    pfam02158
    Location:75430
    Neuregulin; Neuregulin family
  20. XM_036153860.1XP_036009753.1  pro-neuregulin-1, membrane-bound isoform isoform X23

    Conserved Domains (1) summary
    pfam02158
    Location:9364
    Neuregulin; Neuregulin family
  21. XM_017312641.1XP_017168130.1  pro-neuregulin-1, membrane-bound isoform isoform X22

    Conserved Domains (1) summary
    pfam02158
    Location:39394
    Neuregulin; Neuregulin family
  22. XM_011242133.1XP_011240435.1  pro-neuregulin-1, membrane-bound isoform isoform X21

    Conserved Domains (1) summary
    pfam02158
    Location:73428
    Neuregulin; Neuregulin family
  23. XM_006509077.5XP_006509140.1  pro-neuregulin-1, membrane-bound isoform isoform X14

    Conserved Domains (3) summary
    cd05895
    Location:266340
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    PHA03099
    Location:395484
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    pfam02158
    Location:477634
    Neuregulin; Neuregulin family
  24. XM_006509076.5XP_006509139.1  pro-neuregulin-1, membrane-bound isoform isoform X13

    Conserved Domains (3) summary
    cd05895
    Location:266340
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    pfam00008
    Location:403433
    EGF; EGF-like domain
    pfam02158
    Location:480637
    Neuregulin; Neuregulin family
  25. XM_006509081.4XP_006509144.1  pro-neuregulin-1, membrane-bound isoform isoform X19

    UniProtKB/TrEMBL
    Q3URY7
    Conserved Domains (2) summary
    PHA02887
    Location:236278
    PHA02887; EGF-like protein; Provisional
    pfam02158
    Location:322479
    Neuregulin; Neuregulin family