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rrm1 ribonucleotide reductase M1 polypeptide [ Danio rerio (zebrafish) ]

Gene ID: 30740, updated on 18-Sep-2024

Summary

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Official Symbol
rrm1provided by ZNC
Official Full Name
ribonucleotide reductase M1 polypeptideprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-247
See related
Ensembl:ENSDARG00000014017 AllianceGenome:ZFIN:ZDB-GENE-990415-247
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
r1; cb396; cb838; sb:cb548; CHUNP6866; wu:fb39b07; wu:fi14b02; wu:fk95f07
Summary
Predicted to enable ATP binding activity and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Predicted to be involved in deoxyribonucleotide biosynthetic process. Predicted to be located in cytoplasm. Predicted to be part of ribonucleoside-diphosphate reductase complex. Is expressed in several structures, including immature eye; nervous system; neural tube; presumptive telencephalon; and tail bud. Orthologous to human RRM1 (ribonucleotide reductase catalytic subunit M1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 21
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (30772188..30787414, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (30735190..30750719, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene xrcc1 N-terminal domain containing 1 Neighboring gene transient receptor potential cation channel subfamily C member 2b Neighboring gene uncharacterized LOC137488830 Neighboring gene solute carrier family 6 member 7 Neighboring gene stromal interaction molecule 1b Neighboring gene uncharacterized LOC101886778

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The role of the DNA damage response in zebrafish and cellular models of Diamond Blackfan anemia. Danilova N, et al. Dis Model Mech, 2014 Jul. PMID 24812435, Free PMC Article
  2. Regulation of E2F1 by the von Hippel-Lindau tumour suppressor protein predicts survival in renal cell cancer patients. Mans DA, et al. J Pathol, 2013 Sep. PMID 23744542
  3. GLUT10 is required for the development of the cardiovascular system and the notochord and connects mitochondrial function to TGFβ signaling. Willaert A, et al. Hum Mol Genet, 2012 Mar 15. PMID 22116938, Free PMC Article
  4. Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes. Kuil LE, et al. Elife, 2020 May 5. PMID 32367800, Free PMC Article
  5. Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Recher G, et al. Development, 2013 Dec. PMID 24198278

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in deoxyribonucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within deoxyribonucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in deoxyribonucleotide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoside-diphosphate reductase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ribonucleoside-diphosphate reductase large subunit
Names
ribonucleoside-diphosphate reductase subunit M1
ribonucleotide reductase large subunit
ribonucleotide reductase protein r1 class I
NP_571530.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131455.2 → NP_571530.2  ribonucleoside-diphosphate reductase large subunit

    Status: VALIDATED

    Source sequence(s)
    BX511168, CT631855, CT676109, EB847840, EH588550
    UniProtKB/Swiss-Prot
    P79732
    UniProtKB/TrEMBL
    A0A8M1PC36, F1R2K9
    Related
    ENSDARP00000010800.7, ENSDART00000012091.9
    Conserved Domains (3) summary
    cd01679
    Location:167 → 741
    RNR_I; Class I ribonucleotide reductase
    PLN02437
    Location:1 → 794
    PLN02437; ribonucleoside--diphosphate reductase large subunit
    pfam03477
    Location:1 → 89
    ATP-cone; ATP cone domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    30772188..30787414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P79732.1 GenPept UniProtKB/Swiss-Prot:P79732

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