U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rrm1 ribonucleotide reductase M1 [ Mus musculus (house mouse) ]

Gene ID: 20133, updated on 8-Feb-2024

Summary

Official Symbol
Rrm1provided by MGI
Official Full Name
ribonucleotide reductase M1provided by MGI
Primary source
MGI:MGI:98180
See related
Ensembl:ENSMUSG00000030978 AllianceGenome:MGI:98180
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RnrM1
Summary
Enables disordered domain specific binding activity and purine nucleotide binding activity. Contributes to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in deoxyribonucleotide biosynthetic process and protein heterotetramerization. Part of ribonucleoside-diphosphate reductase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human RRM1 (ribonucleotide reductase catalytic subunit M1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 64.2), liver E14.5 (RPKM 56.2) and 16 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Rrm1 in Genome Data Viewer
Location:
7 E3; 7 54.72 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (102090902..102118978)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (102441695..102469771)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ras homolog family member G Neighboring gene STARR-positive B cell enhancer ABC_E3738 Neighboring gene stromal interaction molecule 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:109486578-109486731 Neighboring gene STARR-positive B cell enhancer mm9_chr7:109495952-109496253 Neighboring gene methyltransferase like 6 pseudogene Neighboring gene STARR-seq mESC enhancer starr_19708 Neighboring gene STARR-positive B cell enhancer ABC_E9112 Neighboring gene STARR-seq mESC enhancer starr_19712 Neighboring gene STARR-seq mESC enhancer starr_19713 Neighboring gene olfactory receptor family 55 subfamily B member 3 Neighboring gene olfactory receptor family 55 subfamily B member 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables disordered domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables purine nucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ribonucleoside-diphosphate reductase activity ISO
Inferred from Sequence Orthology
more info
 
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IDA
Inferred from Direct Assay
more info
PubMed 
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in 2'-deoxyribonucleotide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in 2'-deoxyribonucleotide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA synthesis involved in DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in deoxyribonucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in deoxyribonucleotide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of G0 to G1 transition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of G0 to G1 transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in protein heterotetramerization IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in ribonucleoside diphosphate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ribonucleoside diphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoside-diphosphate reductase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ribonucleoside-diphosphate reductase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoside-diphosphate reductase complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of ribonucleoside-diphosphate reductase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ribonucleoside-diphosphate reductase large subunit
Names
ribonucleoside-diphosphate reductase subunit M1
ribonucleotide reductase large subunit
NP_033129.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009103.3NP_033129.2  ribonucleoside-diphosphate reductase large subunit

    See identical proteins and their annotated locations for NP_033129.2

    Status: VALIDATED

    Source sequence(s)
    AC102535, AK168586
    Consensus CDS
    CCDS40049.1
    UniProtKB/Swiss-Prot
    P07742, Q91YM8
    UniProtKB/TrEMBL
    Q6NZB3
    Related
    ENSMUSP00000033283.10, ENSMUST00000033283.10
    Conserved Domains (3) summary
    cd01679
    Location:167741
    RNR_I; Class I ribonucleotide reductase
    PLN02437
    Location:1792
    PLN02437; ribonucleoside--diphosphate reductase large subunit
    pfam03477
    Location:189
    ATP-cone; ATP cone domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    102090902..102118978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)