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RRM1 ribonucleotide reductase catalytic subunit M1 [ Homo sapiens (human) ]

Gene ID: 6240, updated on 5-Jul-2020

Summary

Official Symbol
RRM1provided by HGNC
Official Full Name
ribonucleotide reductase catalytic subunit M1provided by HGNC
Primary source
HGNC:HGNC:10451
See related
Ensembl:ENSG00000167325 MIM:180410
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
R1; RR1; RIR1
Summary
This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in skin (RPKM 18.5), lymph node (RPKM 18.3) and 25 other tissues See more
Orthologs

Genomic context

See RRM1 in Genome Data Viewer
Location:
11p15.4
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (4094685..4138932)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (4115791..4160116)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene stromal interaction molecule 1 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 21 Neighboring gene ribosomal protein S29 pseudogene 20 Neighboring gene olfactory receptor family 55 subfamily B member 1 pseudogene Neighboring gene long intergenic non-protein coding RNA 2749

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat upregulates the abundance of ribonucleotide reductase M1 (RRM1) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
disordered domain specific binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribonucleoside-diphosphate reductase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
DNA replication IEA
Inferred from Electronic Annotation
more info
 
cell proliferation in forebrain IEA
Inferred from Electronic Annotation
more info
 
deoxyribonucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
deoxyribonucleotide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
nucleobase-containing small molecule interconversion TAS
Traceable Author Statement
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
protein heterotetramerization IEA
Inferred from Electronic Annotation
more info
 
pyrimidine nucleobase metabolic process IEA
Inferred from Electronic Annotation
more info
 
response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
 
retina development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
ribonucleoside-diphosphate reductase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ribonucleoside-diphosphate reductase large subunit
Names
ribonucleoside-diphosphate reductase subunit M1
ribonucleotide reductase M1 polypeptide
ribonucleotide reductase, R1 subunit
NP_001024.1
NP_001304993.1
NP_001304994.1
NP_001317122.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027992.2 RefSeqGene

    Range
    5106..49239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001033.5NP_001024.1  ribonucleoside-diphosphate reductase large subunit isoform 1

    See identical proteins and their annotated locations for NP_001024.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC015689, BC006498, BP229960, BQ775841, CB853003, X59617
    Consensus CDS
    CCDS7750.1
    UniProtKB/Swiss-Prot
    P23921
    Related
    ENSP00000300738.5, ENST00000300738.10
    Conserved Domains (1) summary
    PLN02437
    Location:1792
    PLN02437; ribonucleoside--diphosphate reductase large subunit
  2. NM_001318064.1NP_001304993.1  ribonucleoside-diphosphate reductase large subunit isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translation start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC015689, AK303394, BP229960, BQ775841, CB853003, X59617
    UniProtKB/Swiss-Prot
    P23921
    UniProtKB/TrEMBL
    B4E0I8
    Conserved Domains (2) summary
    cd01679
    Location:70644
    RNR_I; Class I ribonucleotide reductase
    pfam02867
    Location:119641
    Ribonuc_red_lgC; Ribonucleotide reductase, barrel domain
  3. NM_001318065.1NP_001304994.1  ribonucleoside-diphosphate reductase large subunit isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, and uses a downstream translation start site compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC015689, AK301922, AK311593, BC006498, BQ775841, CB853003
    UniProtKB/Swiss-Prot
    P23921
    UniProtKB/TrEMBL
    B4DXD1
    Conserved Domains (2) summary
    PLN02437
    Location:1454
    PLN02437; ribonucleoside--diphosphate reductase large subunit
    cl09939
    Location:49403
    RNR_PFL; Ribonucleotide reductase and Pyruvate formate lyase
  4. NM_001330193.1NP_001317122.1  ribonucleoside-diphosphate reductase large subunit isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC015689, AK311593, BF681281, BM464333
    Consensus CDS
    CCDS81547.1
    UniProtKB/TrEMBL
    E9PL69
    Related
    ENSP00000431464.1, ENST00000534285.5
    Conserved Domains (2) summary
    cd01679
    Location:3519
    RNR_I; Class I ribonucleotide reductase
    pfam02867
    Location:1516
    Ribonuc_red_lgC; Ribonucleotide reductase, barrel domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    4094685..4138932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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