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ANXA4 annexin A4 [ Homo sapiens (human) ]

Gene ID: 307, updated on 23-Dec-2018

Summary

Official Symbol
ANXA4provided by HGNC
Official Full Name
annexin A4provided by HGNC
Primary source
HGNC:HGNC:542
See related
Ensembl:ENSG00000196975 MIM:106491
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANX4; P32.5; PIG28; PP4-X; ZAP36; PAP-II; HEL-S-274
Summary
Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]
Expression
Broad expression in gall bladder (RPKM 187.6), duodenum (RPKM 64.1) and 17 other tissues See more
Orthologs

Genomic context

See ANXA4 in Genome Data Viewer
Location:
2p13.3
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (69643805..69826477)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (69947946..70053596)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene AP2 associated kinase 1 Neighboring gene beta-1,3-N-acetylgalactosaminyltransferase 1 pseudogene 1 Neighboring gene ribosomal protein L36a pseudogene 16 Neighboring gene natural cytotoxicity triggering receptor 3 ligand 1-like Neighboring gene germ cell-less, spermatogenesis associated 1 Neighboring gene ribosomal protein L23a pseudogene 92 Neighboring gene small nuclear ribonucleoprotein U4/U6.U5 subunit 27

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of annexin A4 and V in umbilical cord blood mononuclear cells and T-cell lines but downregulates the expression of annexin A1 in umbilical cord blood mononuclear cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Prostaglandin Synthesis and Regulation, organism-specific biosystem (from WikiPathways)
    Prostaglandin Synthesis and Regulation, organism-specific biosystemA prostaglandin is any member of a group of lipid compounds that are derived enzymatically from fatty acids and have important functions in the animal body. Every prostaglandin contains 20 carbon ato...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC75105, DKFZp686H02120

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NF-kappaB binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent phospholipid binding NAS
Non-traceable Author Statement
more info
PubMed 
calcium-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
chondroitin sulfate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
phospholipase inhibitor activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epithelial cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-8 secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
collagen-containing extracellular matrix HDA PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
annexin A4
Names
35-beta calcimedin
annexin IV (placental anticoagulant protein II)
annexin-4
carbohydrate-binding protein p33/p41
chromobindin-4
endonexin I
epididymis secretory protein Li 274
lipocortin IV
placental anticoagulant protein II
proliferation-inducing gene 28
proliferation-inducing protein 28
protein II

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001153.5NP_001144.1  annexin A4 isoform a

    See identical proteins and their annotated locations for NP_001144.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC019206, AK058017, BC000182, D78152, DB562261
    Consensus CDS
    CCDS1894.1
    UniProtKB/Swiss-Prot
    P09525
    UniProtKB/TrEMBL
    Q6LES2, Q6P452
    Related
    ENSP00000377833.4, ENST00000394295.5
    Conserved Domains (1) summary
    pfam00191
    Location:251316
    Annexin; Annexin
  2. NM_001320698.1NP_001307627.1  annexin A4 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC092431, AK058017, BC000182, D78152, DB562261, DN994496
    Consensus CDS
    CCDS1894.1
    UniProtKB/Swiss-Prot
    P09525
    UniProtKB/TrEMBL
    Q6LES2
    Conserved Domains (1) summary
    pfam00191
    Location:251316
    Annexin; Annexin
  3. NM_001320700.1NP_001307629.1  annexin A4 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK058017, BC063672, D78152, DB562261
    Consensus CDS
    CCDS82459.1
    UniProtKB/Swiss-Prot
    P09525
    UniProtKB/TrEMBL
    Q6P452
    Related
    ENSP00000386756.1, ENST00000409920.5
    Conserved Domains (2) summary
    smart00335
    Location:83135
    ANX; Annexin repeats
    pfam00191
    Location:229294
    Annexin; Annexin
  4. NM_001320702.1NP_001307631.1  annexin A4 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AK058017, AK293177, BC063672, D78152, DB562261
    UniProtKB/Swiss-Prot
    P09525
    UniProtKB/TrEMBL
    Q6P452
    Conserved Domains (1) summary
    pfam00191
    Location:167232
    Annexin; Annexin
  5. NM_001365496.1NP_001352425.1  annexin A4 isoform a

    Status: REVIEWED

    Source sequence(s)
    AA237007, BX110594, CN287596, CU446263, DB562261, DC380425
    Conserved Domains (1) summary
    pfam00191
    Location:251316
    Annexin; Annexin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    69643805..69826477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452834.1XP_024308602.1  annexin A4 isoform X1

    Conserved Domains (1) summary
    pfam00191
    Location:251316
    Annexin; Annexin
  2. XM_017003943.1XP_016859432.1  annexin A4 isoform X1

    UniProtKB/Swiss-Prot
    P09525
    UniProtKB/TrEMBL
    Q6LES2
    Conserved Domains (1) summary
    pfam00191
    Location:251316
    Annexin; Annexin
  3. XM_024452835.1XP_024308603.1  annexin A4 isoform X1

    Conserved Domains (1) summary
    pfam00191
    Location:251316
    Annexin; Annexin
  4. XM_017003944.1XP_016859433.1  annexin A4 isoform X2

    UniProtKB/Swiss-Prot
    P09525
    Conserved Domains (1) summary
    pfam00191
    Location:167232
    Annexin; Annexin
  5. XM_024452836.1XP_024308604.1  annexin A4 isoform X1

    Conserved Domains (1) summary
    pfam00191
    Location:251316
    Annexin; Annexin

RNA

  1. XR_001738734.2 RNA Sequence

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