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Anxa4 annexin A4 [ Mus musculus (house mouse) ]

Gene ID: 11746, updated on 2-Nov-2024

Summary

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Official Symbol
Anxa4provided by MGI
Official Full Name
annexin A4provided by MGI
Primary source
MGI:MGI:88030
See related
Ensembl:ENSMUSG00000029994 AllianceGenome:MGI:88030
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AIV; Anx4; Xanx-4
Summary
Predicted to enable several functions, including NF-kappaB binding activity; calcium-dependent protein binding activity; and phospholipid binding activity. Acts upstream of or within Notch signaling pathway. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; chordamesoderm; inner ear; and lung. Orthologous to human ANXA4 (annexin A4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in large intestine adult (RPKM 135.1), small intestine adult (RPKM 70.5) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Anxa4 in Genome Data Viewer
Location:
6 D1; 6 37.75 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (86713822..86770616, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (86736840..86793634, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:86634487-86634670 Neighboring gene small nuclear ribonucleoprotein 27 (U4/U6.U5) Neighboring gene germ cell-less, spermatogenesis associated 1 Neighboring gene STARR-positive B cell enhancer ABC_E3661 Neighboring gene STARR-seq mESC enhancer starr_16540 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:86774247-86774356 Neighboring gene RIKEN cDNA 2610306M01 gene Neighboring gene STARR-positive B cell enhancer ABC_E6451 Neighboring gene AP2 associated kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E9670 Neighboring gene STARR-positive B cell enhancer ABC_E8113 Neighboring gene STARR-seq mESC enhancer starr_16545 Neighboring gene NFU1 iron-sulfur cluster scaffold

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Intron disruption of the annexin IV gene reveals novel transcripts. Li B, et al. J Biol Chem, 2003 Oct 31. PMID 12912993
  2. Annexin A4 N-terminal peptide inhibits adenylyl cyclase 5 and limits β-adrenoceptor-mediated prolongation of cardiac action potential. Heinick A, et al. FASEB J, 2020 Aug. PMID 32579290
  3. Studies on localization and function of annexin A4a within urinary bladder epithelium using a mouse knockout model. Hill WG, et al. Am J Physiol Renal Physiol, 2008 Apr. PMID 18256316, Free PMC Article
  4. Cloning and functional activity of a novel truncated form of annexin IV in mouse macrophages. Sable CL, et al. Biochem Biophys Res Commun, 1999 Apr 29. PMID 10222253
  5. Chromosomal mapping of the human annexin IV (ANX4) gene. Tait JF, et al. Genomics, 1992 Feb. PMID 1346776

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ANXA4 Activates JAK-STAT3 Signaling by Interacting with ANXA1 in Basal-Like Breast Cancer.
    Title: ANXA4 Activates JAK-STAT3 Signaling by Interacting with ANXA1 in Basal-Like Breast Cancer.
  2. Anxa4 mediated airway progenitor cell migration promotes distal epithelial cell fate specification
    Title: Anxa4 mediated airway progenitor cell migration promotes distal epithelial cell fate specification.
  3. these results suggest that AnxA4 is a novel direct negative regulator of AC5, adding a new facet to the functions of annexins.
    Title: Annexin A4 is a novel direct regulator of adenylyl cyclase type 5.
  4. Fhit delocalizes annexin A4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel.
    Title: Fhit delocalizes annexin a4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel.
  5. NME1 controls annexin IV and EF-1Balpha amounts by post-translational mechanisms.
    Title: Proteomic analysis of NME1/NDPK A null mouse liver: evidence for a post-translational regulation of annexin IV and EF-1Bα.
  6. analysis of intron disruptions in the annexin IV gene that produce novel transcripts
    Title: Intron disruption of the annexin IV gene reveals novel transcripts.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NF-kappaB binding IEA
Inferred from Electronic Annotation
more info
  
enables NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent protein binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within kidney development ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-8 production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in zymogen granule membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
annexin A4
Names
annexin IV
annexin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331120.1 → NP_001318049.1  annexin A4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC157099, AC158662, AK132293, AK150486
    Consensus CDS
    CCDS39543.1
    UniProtKB/Swiss-Prot
    P97429, Q3UCL0
    UniProtKB/TrEMBL
    Q7TMN7
    Conserved Domains (1) summary
    pfam00191
    Location:249 → 314
    Annexin

  2. NM_001409435.1 → NP_001396364.1  annexin A4 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC157099, AC158662

  3. NM_001409436.1 → NP_001396365.1  annexin A4 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC158662

  4. NM_001409437.1 → NP_001396366.1  annexin A4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC157099, AC158662
    UniProtKB/Swiss-Prot
    P97429, Q3UCL0
    Related
    ENSMUSP00000145421.2, ENSMUST00000204441.3

  5. NM_001409438.1 → NP_001396367.1  annexin A4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC157099, AC158662
    UniProtKB/Swiss-Prot
    P97429, Q3UCL0

  6. NM_001409439.1 → NP_001396368.1  annexin A4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC157099, AC158662
    UniProtKB/Swiss-Prot
    P97429, Q3UCL0
    Related
    ENSMUSP00000144961.2, ENSMUST00000204398.2

  7. NM_001409442.1 → NP_001396371.1  annexin A4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC158662
    UniProtKB/Swiss-Prot
    P97429, Q3UCL0
    Related
    ENSMUSP00000109305.2, ENSMUST00000113675.8

  8. NM_001409443.1 → NP_001396372.1  annexin A4 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC157099, AC158662
    Related
    ENSMUSP00000115346.2, ENSMUST00000123732.4

  9. NM_001409444.1 → NP_001396373.1  annexin A4 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC158662

  10. NM_001409445.1 → NP_001396374.1  annexin A4 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC157099, AC158662
    UniProtKB/TrEMBL
    Q8BSL2

  11. NM_001409446.1 → NP_001396375.1  annexin A4 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC158662
    UniProtKB/TrEMBL
    Q8BSL2
    Related
    ENSMUST00000129772.2

  12. NM_001409447.1 → NP_001396376.1  annexin A4 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC158662

  13. NM_001409448.1 → NP_001396377.1  annexin A4 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC157099, AC158662

  14. NM_013471.3 → NP_038499.2  annexin A4 isoform a

    See identical proteins and their annotated locations for NP_038499.2

    Status: VALIDATED

    Source sequence(s)
    AC157099, AC158662
    Consensus CDS
    CCDS39543.1
    UniProtKB/Swiss-Prot
    P97429, Q3UCL0
    UniProtKB/TrEMBL
    Q7TMN7
    Related
    ENSMUSP00000001187.9, ENSMUST00000001187.15
    Conserved Domains (1) summary
    pfam00191
    Location:249 → 314
    Annexin

RNA

  1. NR_176838.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158662

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    86713822..86770616 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165761.1 → XP_036021654.1  annexin A4 isoform X1

    UniProtKB/Swiss-Prot
    P97429, Q3UCL0
    UniProtKB/TrEMBL
    Q7TMN7
    Conserved Domains (1) summary
    pfam00191
    Location:249 → 314
    Annexin

  2. XM_011241158.3 → XP_011239460.1  annexin A4 isoform X2

    UniProtKB/TrEMBL
    Q9R0V2, S4R1F2
    Related
    ENSMUSP00000138194.2, ENSMUST00000127152.9
    Conserved Domains (1) summary
    pfam00191
    Location:90 → 155
    Annexin

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001409440.1: Suppressed sequence

    Description
    NM_001409440.1: This RefSeq was removed because it was redundant with NM_001409437.1.

  2. NM_001409441.1: Suppressed sequence

    Description
    NM_001409441.1: This RefSeq was removed because it was redundant with NM_001409439.1.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97429.4 GenPept UniProtKB/Swiss-Prot:P97429

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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