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H3-3A H3.3 histone A [ Homo sapiens (human) ]

Gene ID: 3020, updated on 2-Mar-2021

Summary

Official Symbol
H3-3Aprovided by HGNC
Official Full Name
H3.3 histone Aprovided by HGNC
Primary source
HGNC:HGNC:4764
See related
Ensembl:ENSG00000163041 MIM:601128
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H3F3; H3-3B; H3.3A; H3F3A
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 595.8), appendix (RPKM 347.4) and 25 other tissues See more
Orthologs
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Genomic context

See H3-3A in Genome Data Viewer
Location:
1q42.12
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (226061831..226072019)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (226249532..226259720)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 pseudogene 3 Neighboring gene SDE2 telomere maintenance homolog Neighboring gene long intergenic non-protein coding RNA 1703 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of H3 histone, family 3A (H3F3A) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Tat stimulates NF-kappaB-inducing kinase IKKalpha translocation from the cytoplasm to the nucleus in monocytes, which leads to IKKalpha and CBP/p300 recruitment to the IL-10 promoter and histone H3 phosphorylation (Ser 10) and acetylation (Lys 14) PubMed
tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC87782, MGC87783

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
nucleosomal DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA replication-independent nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
blood coagulation TAS
Traceable Author Statement
more info
 
cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
embryo implantation IEA
Inferred from Electronic Annotation
more info
 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of chromosome condensation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression, epigenetic TAS
Traceable Author Statement
more info
 
nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
nucleosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleus organization IEA
Inferred from Electronic Annotation
more info
 
oogenesis IEA
Inferred from Electronic Annotation
more info
 
osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
pericentric heterochromatin assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
rDNA heterochromatin assembly TAS
Traceable Author Statement
more info
 
regulation of centromere complex assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of gene silencing by miRNA TAS
Traceable Author Statement
more info
 
regulation of megakaryocyte differentiation TAS
Traceable Author Statement
more info
 
single fertilization IEA
Inferred from Electronic Annotation
more info
 
spermatid development IEA
Inferred from Electronic Annotation
more info
 
subtelomeric heterochromatin assembly IEA
Inferred from Electronic Annotation
more info
 
telomere organization TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Barr body IEA
Inferred from Electronic Annotation
more info
 
chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone H3.3
Names
H3 histone family member 3A
H3 histone, family 3A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_065173.1 RefSeqGene

    Range
    5010..14313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1410

mRNA and Protein(s)

  1. NM_001379043.1NP_001365972.1  histone H3.3

    Status: REVIEWED

    Source sequence(s)
    AL512343
    Related
    ENSP00000355781.1, ENST00000366816.5
    Conserved Domains (1) summary
    PTZ00018
    Location:1136
    PTZ00018; histone H3; Provisional
  2. NM_001379045.1NP_001365974.1  histone H3.3

    Status: REVIEWED

    Source sequence(s)
    AL512343
    Conserved Domains (1) summary
    PTZ00018
    Location:1136
    PTZ00018; histone H3; Provisional
  3. NM_001379046.1NP_001365975.1  histone H3.3

    Status: REVIEWED

    Source sequence(s)
    AL512343
    Conserved Domains (1) summary
    PTZ00018
    Location:1136
    PTZ00018; histone H3; Provisional
  4. NM_001379047.1NP_001365976.1  histone H3.3

    Status: REVIEWED

    Source sequence(s)
    AL512343
    Conserved Domains (1) summary
    PTZ00018
    Location:1136
    PTZ00018; histone H3; Provisional
  5. NM_002107.7NP_002098.1  histone H3.3

    See identical proteins and their annotated locations for NP_002098.1

    Status: REVIEWED

    Source sequence(s)
    AL512343
    Consensus CDS
    CCDS1550.1
    UniProtKB/Swiss-Prot
    P84243
    UniProtKB/TrEMBL
    B2R4P9
    Related
    ENSP00000355780.3, ENST00000366815.9
    Conserved Domains (1) summary
    PTZ00018
    Location:1136
    PTZ00018; histone H3; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    226061831..226072019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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