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ANXA2 annexin A2 [ Homo sapiens (human) ]

Gene ID: 302, updated on 19-Sep-2021

Summary

Official Symbol
ANXA2provided by HGNC
Official Full Name
annexin A2provided by HGNC
Primary source
HGNC:HGNC:537
See related
Ensembl:ENSG00000182718 MIM:151740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P36; ANX2; LIP2; LPC2; CAL1H; LPC2D; ANX2L4; PAP-IV; HEL-S-270
Summary
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. Annexin A2 expression has been found to correlate with resistance to treatment against various cancer forms. [provided by RefSeq, Dec 2019]
Expression
Ubiquitous expression in esophagus (RPKM 162.2), skin (RPKM 128.5) and 24 other tissues See more
Orthologs
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Genomic context

See ANXA2 in Genome Data Viewer
Location:
15q22.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (60347151..60398025, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (60639350..60690185, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370839 Neighboring gene uncharacterized LOC105370840 Neighboring gene ribosomal protein L36a pseudogene 44 Neighboring gene ribosomal protein S10 pseudogene 22 Neighboring gene interactor of little elongation complex ELL subunit 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Meta-analysis of genome-wide association studies in african americans provides insights into the genetic architecture of type 2 diabetes.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Annexin II facilitates early steps in infection of macrophages following to the binding of HIV-1 gp120/gp41 to CD4 and CCR5 PubMed
Envelope transmembrane glycoprotein gp41 env Annexin II facilitates early steps in infection of macrophages following to the binding of HIV-1 gp120/gp41 to CD4 and CCR5 PubMed
Nef nef HIV-1 Nef increases the production of exosomes and co-localizes with exosomal proteins CD63, AIP/Alix, AChE, Hsc70, LAMP2, and annexin A2 in HeLa cells PubMed
Pr55(Gag) gag Annexin 2 (Anx2) interacts with HIV-1 Gag by coimmunoprecipitation in transfected cells and in a cell-free system; Anx2 co-localizes with Gag and CD63 in intracellular vesicles of HIV-1 infected macrophages PubMed
gag Anx2 depletion by siRNA is associated with decreased infectivity of HIV-1 and aberrant HIV-1 Gag processing, indicating an interaction of Anx2 with Gag PubMed
Tat tat In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables S100 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables bone sialoprotein binding IEA
Inferred from Electronic Annotation
more info
 
enables cadherin binding involved in cell-cell adhesion HDA PubMed 
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipase A2 inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipase A2 inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protease binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
enables virion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in body fluid secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in collagen fibril organization IEA
Inferred from Electronic Annotation
more info
 
involved_in fibrinolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane raft assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of low-density lipoprotein particle receptor catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in osteoclast development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of low-density lipoprotein particle clearance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of low-density lipoprotein particle receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of low-density lipoprotein receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of receptor recycling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of receptor-mediated endocytosis involved in cholesterol transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vacuole organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vesicle fusion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in response to thyroid hormone IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle budding from membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of AnxA2-p11 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of PCSK9-AnxA2 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in Schmidt-Lanterman incisure IEA
Inferred from Electronic Annotation
more info
 
located_in adherens junction HDA PubMed 
located_in azurophil granule lumen TAS
Traceable Author Statement
more info
 
located_in basement membrane IEA
Inferred from Electronic Annotation
more info
 
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with collagen-containing extracellular matrix HDA PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
colocalizes_with collagen-containing extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extrinsic component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in late endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in macropinosome IEA
Inferred from Electronic Annotation
more info
 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
colocalizes_with membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in myelin sheath adaxonal region IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in ruffle IEA
Inferred from Electronic Annotation
more info
 
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
 
located_in vesicle HDA PubMed 
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
annexin A2
Names
annexin II
annexin-2
calpactin I heavy chain
calpactin I heavy polypeptide
calpactin-1 heavy chain
chromobindin 8
epididymis secretory protein Li 270
epididymis secretory sperm binding protein
lipocortin II
placental anticoagulant protein IV
protein I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002857.2NP_001002857.1  annexin A2 isoform 2

    See identical proteins and their annotated locations for NP_001002857.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1. It uses a downstream AUG start codon and encodes isoform 2 which has a shorter N-terminus, as compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AW087150, BC015834, BC023990
    Consensus CDS
    CCDS10175.1
    UniProtKB/Swiss-Prot
    P07355
    UniProtKB/TrEMBL
    A0A024R5Z7
    Related
    ENSP00000411352.2, ENST00000421017.6
    Conserved Domains (1) summary
    pfam00191
    Location:109174
    Annexin
  2. NM_001002858.3NP_001002858.1  annexin A2 isoform 1

    See identical proteins and their annotated locations for NP_001002858.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA661718, AC087385, BC001388, BX640598
    Consensus CDS
    CCDS32256.1
    UniProtKB/Swiss-Prot
    P07355
    Related
    ENSP00000346032.3, ENST00000332680.8
    Conserved Domains (1) summary
    pfam00191
    Location:127192
    Annexin; Annexin
  3. NM_001136015.3NP_001129487.1  annexin A2 isoform 2

    See identical proteins and their annotated locations for NP_001129487.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 5' UTR, as compared to variant 1. It uses a downstream AUG start codon and encodes isoform 2 which has a shorter N-terminus, as compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AA661718, BC093056
    Consensus CDS
    CCDS10175.1
    UniProtKB/Swiss-Prot
    P07355
    UniProtKB/TrEMBL
    A0A024R5Z7
    Related
    ENSP00000379342.3, ENST00000396024.7
    Conserved Domains (1) summary
    pfam00191
    Location:109174
    Annexin
  4. NM_004039.3NP_004030.1  annexin A2 isoform 2

    See identical proteins and their annotated locations for NP_004030.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a segment in the 5' region, as compared to variant 1. It uses a downstream AUG start codon and encodes isoform 2 which has a shorter N-terminus, as compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AW087150, BC015834, D00017
    Consensus CDS
    CCDS10175.1
    UniProtKB/Swiss-Prot
    P07355
    UniProtKB/TrEMBL
    A0A024R5Z7
    Related
    ENSP00000387545.3, ENST00000451270.7
    Conserved Domains (1) summary
    pfam00191
    Location:109174
    Annexin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    60347151..60398025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022092.1XP_016877581.1  annexin A2 isoform X2

    Related
    ENSP00000453869.2, ENST00000559113.6
    Conserved Domains (1) summary
    pfam00191
    Location:152217
    Annexin
  2. XM_017022093.1XP_016877582.1  annexin A2 isoform X2

    Related
    ENSP00000453039.2, ENST00000558985.6
    Conserved Domains (1) summary
    pfam00191
    Location:152217
    Annexin
  3. XM_017022091.1XP_016877580.1  annexin A2 isoform X1

    UniProtKB/Swiss-Prot
    P07355
    UniProtKB/TrEMBL
    A0A024R5Z7
    Conserved Domains (1) summary
    pfam00191
    Location:109174
    Annexin
  4. XM_024449908.1XP_024305676.1  annexin A2 isoform X2

    Conserved Domains (1) summary
    pfam00191
    Location:152217
    Annexin
  5. XM_017022090.1XP_016877579.1  annexin A2 isoform X1

    UniProtKB/Swiss-Prot
    P07355
    UniProtKB/TrEMBL
    A0A024R5Z7
    Conserved Domains (1) summary
    pfam00191
    Location:109174
    Annexin
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