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ANXA2 annexin A2 [ Homo sapiens (human) ]

Gene ID: 302, updated on 17-Jun-2019

Summary

Official Symbol
ANXA2provided by HGNC
Official Full Name
annexin A2provided by HGNC
Primary source
HGNC:HGNC:537
See related
Ensembl:ENSG00000182718 MIM:151740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P36; ANX2; LIP2; LPC2; CAL1H; LPC2D; ANX2L4; PAP-IV; HEL-S-270
Summary
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in esophagus (RPKM 162.2), skin (RPKM 128.5) and 24 other tissues See more
Orthologs

Genomic context

See ANXA2 in Genome Data Viewer
Location:
15q22.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (60347151..60398025, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (60639350..60690185, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370839 Neighboring gene uncharacterized LOC105370840 Neighboring gene ribosomal protein L36a pseudogene 44 Neighboring gene ribosomal protein S10 pseudogene 22 Neighboring gene interactor of little elongation complex ELL subunit 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Meta-analysis of genome-wide association studies in african americans provides insights into the genetic architecture of type 2 diabetes.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Annexin II facilitates early steps in infection of macrophages following to the binding of HIV-1 gp120/gp41 to CD4 and CCR5 PubMed
Envelope transmembrane glycoprotein gp41 env Annexin II facilitates early steps in infection of macrophages following to the binding of HIV-1 gp120/gp41 to CD4 and CCR5 PubMed
Nef nef HIV-1 Nef increases the production of exosomes and co-localizes with exosomal proteins CD63, AIP/Alix, AChE, Hsc70, LAMP2, and annexin A2 in HeLa cells PubMed
Pr55(Gag) gag Annexin 2 (Anx2) interacts with HIV-1 Gag by coimmunoprecipitation in transfected cells and in a cell-free system; Anx2 co-localizes with Gag and CD63 in intracellular vesicles of HIV-1 infected macrophages PubMed
gag Anx2 depletion by siRNA is associated with decreased infectivity of HIV-1 and aberrant HIV-1 Gag processing, indicating an interaction of Anx2 with Gag PubMed
Tat tat In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Dissolution of Fibrin Clot, organism-specific biosystem (from REACTOME)
    Dissolution of Fibrin Clot, organism-specific biosystemThe crosslinked fibrin multimers in a clot are broken down to soluble polypeptides by plasmin, a serine protease. Plasmin can be generated from its inactive precursor plasminogen and recruited to the...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Prostaglandin Synthesis and Regulation, organism-specific biosystem (from WikiPathways)
    Prostaglandin Synthesis and Regulation, organism-specific biosystemA prostaglandin is any member of a group of lipid compounds that are derived enzymatically from fatty acids and have important functions in the animal body. Every prostaglandin contains 20 carbon ato...
  • Smooth Muscle Contraction, organism-specific biosystem (from REACTOME)
    Smooth Muscle Contraction, organism-specific biosystemLayers of smooth muscle cells can be found in the walls of numerous organs and tissues within the body. Smooth muscle tissue lacks the striated banding pattern characteristic of skeletal and cardiac ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
Rab GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
S100 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
S100 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
bone sialoprotein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cadherin binding involved in cell-cell adhesion HDA PubMed 
calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
molecular function regulator IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-4,5-bisphosphate binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipase A2 inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipase A2 inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
protease binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
virion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
biomineral tissue development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
body fluid secretion IEA
Inferred from Electronic Annotation
more info
 
calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
catabolism by host of symbiont protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
catabolism by host of symbiont protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
collagen fibril organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endocardial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fibrinolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth plate cartilage development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-12-mediated signaling pathway TAS
Traceable Author Statement
more info
 
membrane raft assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane raft assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation by host of symbiont molecular function IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation by host of symbiont molecular function IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of development of symbiont involved in interaction with host IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of development of symbiont involved in interaction with host IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of low-density lipoprotein particle receptor catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of low-density lipoprotein particle receptor catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
osteoclast development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
osteoclast development IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation by host of viral process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of calcium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of chondrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of fibroblast proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of low-density lipoprotein particle clearance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of low-density lipoprotein particle clearance IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of low-density lipoprotein particle receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of low-density lipoprotein particle receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of low-density lipoprotein receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of low-density lipoprotein receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of receptor recycling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of receptor recycling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of receptor-mediated endocytosis involved in cholesterol transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of receptor-mediated endocytosis involved in cholesterol transport IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of vacuole organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of vacuole organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of vesicle fusion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of viral life cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein heterotetramerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein heterotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
regulation of plasminogen activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to thyroid hormone IEA
Inferred from Electronic Annotation
more info
 
vesicle budding from membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle budding from membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
PCSK9-AnxA2 complex IDA
Inferred from Direct Assay
more info
PubMed 
Schmidt-Lanterman incisure IEA
Inferred from Electronic Annotation
more info
 
azurophil granule lumen TAS
Traceable Author Statement
more info
 
basement membrane IEA
Inferred from Electronic Annotation
more info
 
basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell adherens junction HDA PubMed 
collagen-containing extracellular matrix HDA PubMed 
colocalizes_with collagen-containing extracellular matrix HDA PubMed 
colocalizes_with collagen-containing extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
early endosome IEA
Inferred from Electronic Annotation
more info
 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extrinsic component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
late endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
macropinosome IEA
Inferred from Electronic Annotation
more info
 
melanosome IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
colocalizes_with membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
myelin sheath adaxonal region IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
ruffle IEA
Inferred from Electronic Annotation
more info
 
sarcolemma IEA
Inferred from Electronic Annotation
more info
 
vesicle HDA PubMed 
vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
annexin A2
Names
annexin II
annexin-2
calpactin I heavy chain
calpactin I heavy polypeptide
calpactin-1 heavy chain
chromobindin 8
epididymis secretory protein Li 270
epididymis secretory sperm binding protein
lipocortin II
placental anticoagulant protein IV
protein I

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002857.2NP_001002857.1  annexin A2 isoform 2

    See identical proteins and their annotated locations for NP_001002857.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1. It uses a downstream AUG start codon and encodes isoform 2 which has a shorter N-terminus, as compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AW087150, BC015834, BC023990
    Consensus CDS
    CCDS10175.1
    UniProtKB/Swiss-Prot
    P07355
    UniProtKB/TrEMBL
    A0A024R5Z7
    Related
    ENSP00000411352.2, ENST00000421017.6
    Conserved Domains (1) summary
    pfam00191
    Location:109174
    Annexin; Annexin
  2. NM_001002858.3NP_001002858.1  annexin A2 isoform 1

    See identical proteins and their annotated locations for NP_001002858.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA661718, AC087385, BC001388, BX640598
    Consensus CDS
    CCDS32256.1
    UniProtKB/Swiss-Prot
    P07355
    Related
    ENSP00000346032.3, ENST00000332680.8
    Conserved Domains (1) summary
    pfam00191
    Location:127192
    Annexin; Annexin
  3. NM_001136015.3NP_001129487.1  annexin A2 isoform 2

    See identical proteins and their annotated locations for NP_001129487.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 5' UTR, as compared to variant 1. It uses a downstream AUG start codon and encodes isoform 2 which has a shorter N-terminus, as compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AA661718, BC093056
    Consensus CDS
    CCDS10175.1
    UniProtKB/Swiss-Prot
    P07355
    UniProtKB/TrEMBL
    A0A024R5Z7
    Related
    ENSP00000379342.3, ENST00000396024.7
    Conserved Domains (1) summary
    pfam00191
    Location:109174
    Annexin; Annexin
  4. NM_004039.3NP_004030.1  annexin A2 isoform 2

    See identical proteins and their annotated locations for NP_004030.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a segment in the 5' region, as compared to variant 1. It uses a downstream AUG start codon and encodes isoform 2 which has a shorter N-terminus, as compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AW087150, BC015834, D00017
    Consensus CDS
    CCDS10175.1
    UniProtKB/Swiss-Prot
    P07355
    UniProtKB/TrEMBL
    A0A024R5Z7
    Related
    ENSP00000387545.2, ENST00000451270.6
    Conserved Domains (1) summary
    pfam00191
    Location:109174
    Annexin; Annexin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    60347151..60398025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022092.1XP_016877581.1  annexin A2 isoform X2

    Conserved Domains (1) summary
    pfam00191
    Location:152217
    Annexin; Annexin
  2. XM_017022093.1XP_016877582.1  annexin A2 isoform X2

    Conserved Domains (1) summary
    pfam00191
    Location:152217
    Annexin; Annexin
  3. XM_017022091.1XP_016877580.1  annexin A2 isoform X1

    UniProtKB/Swiss-Prot
    P07355
    UniProtKB/TrEMBL
    A0A024R5Z7
    Conserved Domains (1) summary
    pfam00191
    Location:109174
    Annexin; Annexin
  4. XM_024449908.1XP_024305676.1  annexin A2 isoform X2

    Conserved Domains (1) summary
    pfam00191
    Location:152217
    Annexin; Annexin
  5. XM_017022090.1XP_016877579.1  annexin A2 isoform X1

    UniProtKB/Swiss-Prot
    P07355
    UniProtKB/TrEMBL
    A0A024R5Z7
    Conserved Domains (1) summary
    pfam00191
    Location:109174
    Annexin; Annexin
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