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H1-5 H1.5 linker histone, cluster member [ Homo sapiens (human) ]

Gene ID: 3009, updated on 7-Jun-2020

Summary

Official Symbol
H1-5provided by HGNC
Official Full Name
H1.5 linker histone, cluster memberprovided by HGNC
Primary source
HGNC:HGNC:4719
See related
Ensembl:ENSG00000184357 MIM:142711
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H1; H1B; H1.5; H1F5; H1s-3; HIST1H1B
Summary
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
Orthologs

Genomic context

See H1-5 in Genome Data Viewer
Location:
6p22.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (27866792..27867588, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (27834570..27835359, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H2B clustered histone 16, pseudogene Neighboring gene H2A clustered histone 16 Neighboring gene H3 clustered histone 11 Neighboring gene H4 clustered histone 13

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify H1b associated HIV-1 Gag in 293T cells PubMed
Tat tat Overexpression of NPM1 enhances HIV-1 Tat-mediated transactivation by reducing the histone H1 occupancy on the chromatinized template of HIV-1 LTR PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126630, MGC126632

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
chromatin DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
nucleosomal DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
chromatin organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment of protein localization to chromatin IMP
Inferred from Mutant Phenotype
more info
PubMed 
muscle organ development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of chromatin silencing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
nucleosome positioning IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of histone H3-K9 methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
host cell nucleus IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear euchromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleosome IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone H1.5
Names
H1 histone family, member 5
histone 1, H1b
histone H1a
histone H1b
histone H1s-3
histone cluster 1 H1 family member b
histone cluster 1, H1b

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005322.3NP_005313.1  histone H1.5

    See identical proteins and their annotated locations for NP_005313.1

    Status: REVIEWED

    Source sequence(s)
    Z98744
    Consensus CDS
    CCDS4635.1
    UniProtKB/Swiss-Prot
    P16401
    Related
    ENSP00000330074.3, ENST00000331442.4
    Conserved Domains (1) summary
    pfam00538
    Location:41111
    Linker_histone; linker histone H1 and H5 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    27866792..27867588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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