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Pglyrp2 peptidoglycan recognition protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299567, updated on 17-Aug-2024

Summary

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Symbol
Pglyrp2provided by RGD
Full Name
peptidoglycan recognition protein 2provided by RGD
Primary source
RGD:1359183
See related
EnsemblRapid:ENSRNOG00000042318 AllianceGenome:RGD:1359183
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable N-acetylmuramoyl-L-alanine amidase activity; peptidoglycan binding activity; and peptidoglycan immune receptor activity. Predicted to be involved in defense response to Gram-positive bacterium and detection of bacterium. Predicted to act upstream of or within several processes, including negative regulation of interferon-gamma production; negative regulation of natural killer cell differentiation involved in immune response; and regulation of inflammatory response. Orthologous to human PGLYRP2 (peptidoglycan recognition protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 744.9) See more
Orthologs
human mouse all
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Genomic context

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See Pglyrp2 in Genome Data Viewer
Location:
7q11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (12069414..12082437, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (11418674..11432162, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (14426481..14435987, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene WIZ zinc finger Neighboring gene RAS protein activator like 3 Neighboring gene uncharacterized LOC134479820 Neighboring gene uncharacterized LOC134479822 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 39 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase. Wang ZM, et al. J Biol Chem, 2003 Dec 5. PMID 14506276
  2. Peptidoglycan recognition protein Pglyrp2 protects mice from psoriasis-like skin inflammation by promoting regulatory T cells and limiting Th17 responses. Park SY, et al. J Immunol, 2011 Dec 1. PMID 22048773, Free PMC Article
  3. Peptidoglycan recognition proteins protect mice from experimental colitis by promoting normal gut flora and preventing induction of interferon-gamma. Saha S, et al. Cell Host Microbe, 2010 Aug 19. PMID 20709292, Free PMC Article
  4. PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation. Saha S, et al. Cell Host Microbe, 2009 Feb 19. PMID 19218085, Free PMC Article
  5. Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules. Liu C, et al. J Biol Chem, 2001 Sep 14. PMID 11461926

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acetylmuramoyl-L-alanine amidase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidoglycan binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidoglycan immune receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within biological process involved in interaction with host ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in detection of bacterium ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of natural killer cell differentiation involved in immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidoglycan catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
N-acetylmuramoyl-L-alanine amidase
NP_001386642.1
XP_006241155.1
XP_038935976.1
XP_063119225.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399713.1 → NP_001386642.1  N-acetylmuramoyl-L-alanine amidase precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    M0R485
    Related
    ENSRNOP00000064165.3, ENSRNOT00000074801.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    12069414..12082437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263155.1 → XP_063119225.1  N-acetylmuramoyl-L-alanine amidase isoform X1

    UniProtKB/TrEMBL
    M0R485

  2. XM_039080048.2 → XP_038935976.1  N-acetylmuramoyl-L-alanine amidase isoform X1

    UniProtKB/TrEMBL
    M0R485
    Conserved Domains (1) summary
    smart00701
    Location:352 → 497
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

  3. XM_006241093.5 → XP_006241155.1  N-acetylmuramoyl-L-alanine amidase isoform X2

    Conserved Domains (1) summary
    cl02712
    Location:352 → 419
    PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...
Nucleotide Protein Strain
Heading Accession and Version

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