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PGLYRP2 peptidoglycan recognition protein 2 [ Homo sapiens (human) ]

Gene ID: 114770, updated on 5-Jul-2025
Official Symbol
PGLYRP2provided by HGNC
Official Full Name
peptidoglycan recognition protein 2provided by HGNC
Primary source
HGNC:HGNC:30013
See related
Ensembl:ENSG00000161031 MIM:608199; AllianceGenome:HGNC:30013
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
tagL; PGRPL; PGRP-L; PGLYRPL; HMFT0141; TAGL-like; tagl-beta; tagL-alpha
Summary
This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. This protein hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in bacterial cell wall glycopeptides, and thus may play a scavenger role by digesting biologically active peptidoglycan into biologically inactive fragments. [provided by RefSeq, Sep 2011]
Expression
Restricted expression toward liver (RPKM 52.9) See more
Orthologs
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See PGLYRP2 in Genome Data Viewer
Location:
19p13.12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (15468645..15479501, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (15593641..15604523, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15579456..15590312, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene WIZ zinc finger Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10281 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14185 Neighboring gene microRNA 1470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14188 Neighboring gene RAS protein activator like 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:15618980-15619480 Neighboring gene staufen double-stranded RNA binding protein 1 pseudogene Neighboring gene cytochrome P450 family 4 subfamily F member 22 Neighboring gene MPRA-validated peak3387 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10283 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14191 Neighboring gene cytochrome P450 family 4 subfamily F member 23, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10285

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-acetylmuramoyl-L-alanine amidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables N-acetylmuramoyl-L-alanine amidase activity IEA
Inferred from Electronic Annotation
more info
 
enables N-acetylmuramoyl-L-alanine amidase activity TAS
Traceable Author Statement
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidoglycan binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidoglycan immune receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidoglycan immune receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
N-acetylmuramoyl-L-alanine amidase
Names
peptidoglycan recognition protein L
peptidoglycan recognition protein long
NP_001350475.1
NP_443122.3

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363546.1NP_001350475.1  N-acetylmuramoyl-L-alanine amidase isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AK055882, AY358156, BC144238
    Consensus CDS
    CCDS86718.1
    Related
    ENSP00000292609.3, ENST00000292609.8
    Conserved Domains (1) summary
    smart00701
    Location:380525
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
  2. NM_052890.4NP_443122.3  N-acetylmuramoyl-L-alanine amidase isoform 1 precursor

    See identical proteins and their annotated locations for NP_443122.3

    Status: VALIDATED

    Source sequence(s)
    AF384856, DB041324
    Consensus CDS
    CCDS12330.2
    UniProtKB/Swiss-Prot
    A8K050, A8K8C7, B2RMZ2, B7ZM33, Q68CK1, Q96N74, Q96PD5, Q9UC60
    Related
    ENSP00000345968.4, ENST00000340880.5
    Conserved Domains (1) summary
    smart00701
    Location:380525
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    15468645..15479501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    15593641..15604523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)