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PGLYRP2 peptidoglycan recognition protein 2 [ Homo sapiens (human) ]

Gene ID: 114770, updated on 7-Jun-2020

Summary

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Official Symbol
PGLYRP2provided by HGNC
Official Full Name
peptidoglycan recognition protein 2provided by HGNC
Primary source
HGNC:HGNC:30013
See related
Ensembl:ENSG00000161031 MIM:608199
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
tagL; PGRPL; PGRP-L; PGLYRPL; HMFT0141; TAGL-like; tagl-beta; tagL-alpha
Summary
This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. This protein hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in bacterial cell wall glycopeptides, and thus may play a scavenger role by digesting biologically active peptidoglycan into biologically inactive fragments. [provided by RefSeq, Sep 2011]
Expression
Restricted expression toward liver (RPKM 52.9) See more
Orthologs
mouse all

Genomic context

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See PGLYRP2 in Genome Data Viewer
Location:
19p13.12
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (15468645..15479501, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15579456..15590315, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene WIZ zinc finger Neighboring gene microRNA 1470 Neighboring gene RAS protein activator like 3 Neighboring gene staufen double-stranded RNA binding protein 1 pseudogene Neighboring gene cytochrome P450 family 4 subfamily F member 22 Neighboring gene cytochrome P450 family 4 subfamily F member 23, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Differential expression of peptidoglycan recognition protein 2 in the skin and liver requires different transcription factors. Li X, et al. J Biol Chem, 2006 Jul 28. PMID 16714290
  2. Peptidoglycan recognition protein 2 (N-acetylmuramoyl-L-Ala amidase) is induced in keratinocytes by bacteria through the p38 kinase pathway. Wang H, et al. Infect Immun, 2005 Nov. PMID 16239516, Free PMC Article
  3. Identification of serum N-acetylmuramoyl-l-alanine amidase as liver peptidoglycan recognition protein 2. Zhang Y, et al. Biochim Biophys Acta, 2005 Aug 31. PMID 16054449
  4. Characterization of human serum N-acetylmuramyl-L-alanine amidase purified by affinity chromatography. De Pauw P, et al. Protein Expr Purif, 1995 Jun. PMID 7663175
  5. Regulation of the Peptidoglycan Amidase PGLYRP2 in Epithelial Cells by Interleukin-36γ. Scholz GM, et al. Infect Immun, 2018 Sep. PMID 29914927, Free PMC Article

See all (30) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The expression of IL-36gamma by oral epithelial cells in response to P. gingivalis might enable the subsequent autocrine stimulation of PGLYRP2 expression. Our data identify how IL-36gamma may promote oral mucosal homeostasis by regulating PGLYRP2 expression.
    Title: Regulation of the Peptidoglycan Amidase PGLYRP2 in Epithelial Cells by Interleukin-36γ.
  2. a significant induction of three PGLYRPs 2-4 in primary human corneal epithelial cells (HCECs) exposed to live or heat-killed Candida albicans, is reported.
    Title: A Novel Innate Response of Human Corneal Epithelium to Heat-killed Candida albicans by Producing Peptidoglycan Recognition Proteins.
  3. This study demonistrated that PGLYRP2 single-nucleotide polymorphisms is risk of Parkinson's disease.
    Title: Peptidoglycan recognition protein genes and risk of Parkinson's disease.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: New genetic associations detected in a host response study to hepatitis B vaccine.
  5. Various types of human blood cells were tested for expression of the Tag7/PGRP-SA and TagL/PGRP-L proteins, which belong to the family of proteins possessing the lysozyme-like peptidoglycan recognition protein (PGRP) domain
    Title: [Expression analysis of proteins encoded by genes of the tag7/tagL (PGRP-S,L) family in human peripheral blood cells].
  6. pglyrp2 expression in skin and liver is important for systemic and local innate immune responses to bacterial infections
    Title: Differential expression of peptidoglycan recognition protein 2 in the skin and liver requires different transcription factors.
  7. Serum N-acetylmuramoyl-l-alanine amidaseand liver PGLYRP2 are the same protein encoded by the pglyrp2 gene.
    Title: Identification of serum N-acetylmuramoyl-l-alanine amidase as liver peptidoglycan recognition protein 2.
  8. PGLYRP2 may function in the skin and the eyes as an inducible scavenger of proinflammatory peptidoglycan.
    Title: Peptidoglycan recognition protein 2 (N-acetylmuramoyl-L-Ala amidase) is induced in keratinocytes by bacteria through the p38 kinase pathway.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-acetylmuramoyl-L-alanine amidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
N-acetylmuramoyl-L-alanine amidase activity TAS
Traceable Author Statement
more info
 PubMed 
peptidoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
peptidoglycan binding IDA
Inferred from Direct Assay
more info
 PubMed 
peptidoglycan receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
peptidoglycan receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
antimicrobial humoral response TAS
Traceable Author Statement
more info
  
defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
detection of bacterium IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
detection of bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
growth of symbiont in host IEA
Inferred from Electronic Annotation
more info
  
innate immune response NAS
Non-traceable Author Statement
more info
 PubMed 
negative regulation of interferon-gamma production IEA
Inferred from Electronic Annotation
more info
  
negative regulation of natural killer cell differentiation involved in immune response IEA
Inferred from Electronic Annotation
more info
  
peptide amidation NAS
Non-traceable Author Statement
more info
 PubMed 
peptidoglycan catabolic process IEA
Inferred from Electronic Annotation
more info
  
regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
  
membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
N-acetylmuramoyl-L-alanine amidase
Names
peptidoglycan recognition protein L
peptidoglycan recognition protein long
NP_001350475.1
NP_443122.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363546.1 → NP_001350475.1  N-acetylmuramoyl-L-alanine amidase isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AK055882, AY358156, BC144238
    Consensus CDS
    CCDS86718.1
    Related
    ENSP00000292609.3, ENST00000292609.8
    Conserved Domains (1) summary
    smart00701
    Location:380 → 525
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

  2. NM_052890.4 → NP_443122.3  N-acetylmuramoyl-L-alanine amidase isoform 1 precursor

    See identical proteins and their annotated locations for NP_443122.3

    Status: VALIDATED

    Source sequence(s)
    AF384856, DB041324
    Consensus CDS
    CCDS12330.2
    UniProtKB/Swiss-Prot
    Q96PD5
    Related
    ENSP00000345968.4, ENST00000340880.5
    Conserved Domains (1) summary
    smart00701
    Location:380 → 525
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    15468645..15479501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96PD5.1 GenPept UniProtKB/Swiss-Prot:Q96PD5

Gene LinkOut

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