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PGLYRP2 peptidoglycan recognition protein 2 [ Homo sapiens (human) ]

Gene ID: 114770, updated on 5-Jul-2025
Official Symbol
PGLYRP2provided by HGNC
Official Full Name
peptidoglycan recognition protein 2provided by HGNC
Primary source
HGNC:HGNC:30013
See related
Ensembl:ENSG00000161031 MIM:608199; AllianceGenome:HGNC:30013
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
tagL; PGRPL; PGRP-L; PGLYRPL; HMFT0141; TAGL-like; tagl-beta; tagL-alpha
Summary
This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. This protein hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in bacterial cell wall glycopeptides, and thus may play a scavenger role by digesting biologically active peptidoglycan into biologically inactive fragments. [provided by RefSeq, Sep 2011]
Expression
Restricted expression toward liver (RPKM 52.9) See more
Orthologs
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See PGLYRP2 in Genome Data Viewer
Location:
19p13.12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (15468645..15479501, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (15593641..15604523, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15579456..15590312, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene WIZ zinc finger Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10281 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14185 Neighboring gene microRNA 1470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14188 Neighboring gene RAS protein activator like 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:15618980-15619480 Neighboring gene staufen double-stranded RNA binding protein 1 pseudogene Neighboring gene cytochrome P450 family 4 subfamily F member 22 Neighboring gene MPRA-validated peak3387 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10283 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14191 Neighboring gene cytochrome P450 family 4 subfamily F member 23, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10285

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Differential expression of peptidoglycan recognition protein 2 in the skin and liver requires different transcription factors. Li X, et al. J Biol Chem, 2006 Jul 28. PMID 16714290
  2. Characterization of human serum N-acetylmuramyl-L-alanine amidase purified by affinity chromatography. De Pauw P, et al. Protein Expr Purif, 1995 Jun. PMID 7663175
  3. Identification of serum N-acetylmuramoyl-l-alanine amidase as liver peptidoglycan recognition protein 2. Zhang Y, et al. Biochim Biophys Acta, 2005 Aug 31. PMID 16054449
  4. Peptidoglycan recognition protein 2 (N-acetylmuramoyl-L-Ala amidase) is induced in keratinocytes by bacteria through the p38 kinase pathway. Wang H, et al. Infect Immun, 2005 Nov. PMID 16239516, Free PMC Article
  5. Association of PGLYRP2 gene polymorphism and sporadic Parkinson's disease in northern Chinese Han population. Luan M, et al. Neurosci Lett, 2022 Apr 1. PMID 35218888

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association of PGLYRP2 gene polymorphism and sporadic Parkinson's disease in northern Chinese Han population.
    Title: Association of PGLYRP2 gene polymorphism and sporadic Parkinson's disease in northern Chinese Han population.
  2. PGLYRP2 as a novel biomarker for the activity and lipid metabolism of systemic lupus erythematosus.
    Title: PGLYRP2 as a novel biomarker for the activity and lipid metabolism of systemic lupus erythematosus.
  3. Antibody to peptidoglycan recognition protein (PGLYRP)-2 as a novel biomarker in rheumatoid arthritis.
    Title: Antibody to peptidoglycan recognition protein (PGLYRP)-2 as a novel biomarker in rheumatoid arthritis.
  4. Serum sCD14, PGLYRP2 and FGA as potential biomarkers for multidrug-resistant tuberculosis based on data-independent acquisition and targeted proteomics.
    Title: Serum sCD14, PGLYRP2 and FGA as potential biomarkers for multidrug-resistant tuberculosis based on data-independent acquisition and targeted proteomics.
  5. Tumor-Derived Peptidoglycan Recognition Protein 2 Predicts Survival and Antitumor Immune Responses in Hepatocellular Carcinoma.
    Title: Tumor-Derived Peptidoglycan Recognition Protein 2 Predicts Survival and Antitumor Immune Responses in Hepatocellular Carcinoma.
  6. The expression of IL-36gamma by oral epithelial cells in response to P. gingivalis might enable the subsequent autocrine stimulation of PGLYRP2 expression. Our data identify how IL-36gamma may promote oral mucosal homeostasis by regulating PGLYRP2 expression.
    Title: Regulation of the Peptidoglycan Amidase PGLYRP2 in Epithelial Cells by Interleukin-36γ.
  7. a significant induction of three PGLYRPs 2-4 in primary human corneal epithelial cells (HCECs) exposed to live or heat-killed Candida albicans, is reported.
    Title: A Novel Innate Response of Human Corneal Epithelium to Heat-killed Candida albicans by Producing Peptidoglycan Recognition Proteins.
  8. This study demonistrated that PGLYRP2 single-nucleotide polymorphisms is risk of Parkinson's disease.
    Title: Peptidoglycan recognition protein genes and risk of Parkinson's disease.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: New genetic associations detected in a host response study to hepatitis B vaccine.
  10. Various types of human blood cells were tested for expression of the Tag7/PGRP-SA and TagL/PGRP-L proteins, which belong to the family of proteins possessing the lysozyme-like peptidoglycan recognition protein (PGRP) domain
    Title: [Expression analysis of proteins encoded by genes of the tag7/tagL (PGRP-S,L) family in human peripheral blood cells].
Submit: New GeneRIF Correction See all GeneRIFs (13)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-acetylmuramoyl-L-alanine amidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acetylmuramoyl-L-alanine amidase activity IEA
Inferred from Electronic Annotation
more info
  
enables N-acetylmuramoyl-L-alanine amidase activity TAS
Traceable Author Statement
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidoglycan binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidoglycan binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidoglycan immune receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidoglycan immune receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within biological process involved in interaction with host IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in detection of bacterium IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within negative regulation of natural killer cell differentiation involved in immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of type II interferon production IEA
Inferred from Electronic Annotation
more info
  
involved_in peptide amidation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in peptidoglycan catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
N-acetylmuramoyl-L-alanine amidase
Names
peptidoglycan recognition protein L
peptidoglycan recognition protein long
NP_001350475.1
NP_443122.3

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363546.1 → NP_001350475.1  N-acetylmuramoyl-L-alanine amidase isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AK055882, AY358156, BC144238
    Consensus CDS
    CCDS86718.1
    Related
    ENSP00000292609.3, ENST00000292609.8
    Conserved Domains (1) summary
    smart00701
    Location:380 → 525
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

  2. NM_052890.4 → NP_443122.3  N-acetylmuramoyl-L-alanine amidase isoform 1 precursor

    See identical proteins and their annotated locations for NP_443122.3

    Status: VALIDATED

    Source sequence(s)
    AF384856, DB041324
    Consensus CDS
    CCDS12330.2
    UniProtKB/Swiss-Prot
    A8K050, A8K8C7, B2RMZ2, B7ZM33, Q68CK1, Q96N74, Q96PD5, Q9UC60
    Related
    ENSP00000345968.4, ENST00000340880.5
    Conserved Domains (1) summary
    smart00701
    Location:380 → 525
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    15468645..15479501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    15593641..15604523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96PD5.1 GenPept UniProtKB/Swiss-Prot:Q96PD5

Gene LinkOut

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