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Pglyrp2 peptidoglycan recognition protein 2 [ Mus musculus (house mouse) ]

Gene ID: 57757, updated on 26-Sep-2022

Summary

Official Symbol
Pglyrp2provided by MGI
Official Full Name
peptidoglycan recognition protein 2provided by MGI
Primary source
MGI:MGI:1928099
See related
Ensembl:ENSMUSG00000079563 AllianceGenome:MGI:1928099
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
tagL; PGRP-L; Pglyrpl; C730002N09Rik
Summary
Predicted to enable N-acetylmuramoyl-L-alanine amidase activity; peptidoglycan binding activity; and peptidoglycan immune receptor activity. Acts upstream of or within several processes, including negative regulation of interferon-gamma production; negative regulation of natural killer cell differentiation involved in immune response; and regulation of inflammatory response. Predicted to be located in extracellular region and membrane. Is expressed in hemolymphoid system and thymus primordium. Orthologous to human PGLYRP2 (peptidoglycan recognition protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 42.8), thymus adult (RPKM 34.2) and 4 other tissues See more
Orthologs
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Genomic context

See Pglyrp2 in Genome Data Viewer
Location:
17; 17 B1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (32631433..32643157, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (32412459..32424219, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene widely-interspaced zinc finger motifs Neighboring gene RIKEN cDNA A530088E08 gene Neighboring gene predicted gene, 53995 Neighboring gene RAS protein activator like 3 Neighboring gene predicted gene, 41569 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 39 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 17

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetylmuramoyl-L-alanine amidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptidoglycan binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidoglycan immune receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptidoglycan immune receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
N-acetylmuramoyl-L-alanine amidase
Names
peptidoglycan recognition protein long
NP_001258405.1
NP_001258406.1
NP_001258407.1
NP_001258408.1
NP_067294.2
XP_006524773.1
XP_006524774.1
XP_006524775.1
XP_006524776.1
XP_006524777.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271476.1NP_001258405.1  N-acetylmuramoyl-L-alanine amidase isoform a precursor

    See identical proteins and their annotated locations for NP_001258405.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a, also known as TagL-alpha).
    Source sequence(s)
    AK039953, AY282722, CT485616
    Consensus CDS
    CCDS37557.1
    UniProtKB/Swiss-Prot
    Q8VCS0, Q9QXZ2
    Related
    ENSMUSP00000158365.2, ENSMUST00000236386.2
    Conserved Domains (1) summary
    smart00701
    Location:360505
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
  2. NM_001271477.1NP_001258406.1  N-acetylmuramoyl-L-alanine amidase isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK050019, CT485616
    Consensus CDS
    CCDS89066.1
    UniProtKB/TrEMBL
    A0A498WFR9
    Related
    ENSMUSP00000110099.3, ENSMUST00000114455.3
    Conserved Domains (1) summary
    cl02712
    Location:360421
    PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...
  3. NM_001271478.1NP_001258407.1  N-acetylmuramoyl-L-alanine amidase isoform c precursor

    See identical proteins and their annotated locations for NP_001258407.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (c, also known as TagL-epsilon) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK039953, AY282722, CT485616
    Consensus CDS
    CCDS89065.1
    UniProtKB/Swiss-Prot
    Q8VCS0
    Related
    ENSMUSP00000157771.2, ENSMUST00000237130.2
    Conserved Domains (1) summary
    cl02712
    Location:360427
    PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...
  4. NM_001271479.1NP_001258408.1  N-acetylmuramoyl-L-alanine amidase isoform d precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site and lacks an exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (d, also known as TagL-delta) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AY282722, CT485616
    Consensus CDS
    CCDS89067.1
    UniProtKB/Swiss-Prot
    Q8VCS0
    UniProtKB/TrEMBL
    A0A494B9M1
    Related
    ENSMUSP00000157711.2, ENSMUST00000237165.2
  5. NM_021319.5NP_067294.2  N-acetylmuramoyl-L-alanine amidase isoform a precursor

    See identical proteins and their annotated locations for NP_067294.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 encode the same isoform (a, also known as TagL-alpha).
    Source sequence(s)
    AK050019, AY282722, CT485616
    Consensus CDS
    CCDS37557.1
    UniProtKB/Swiss-Prot
    Q8VCS0, Q9QXZ2
    Related
    ENSMUSP00000129964.2, ENSMUST00000170392.9
    Conserved Domains (1) summary
    smart00701
    Location:360505
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

RNA

  1. NR_073184.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AY282722, CT485616

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    32631433..32643157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524714.4XP_006524777.1  N-acetylmuramoyl-L-alanine amidase isoform X3

    See identical proteins and their annotated locations for XP_006524777.1

    UniProtKB/Swiss-Prot
    Q8VCS0
    Conserved Domains (1) summary
    cl02712
    Location:360427
    PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...
  2. XM_006524713.4XP_006524776.1  N-acetylmuramoyl-L-alanine amidase isoform X2

    Conserved Domains (1) summary
    cl02712
    Location:360421
    PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...
  3. XM_006524712.4XP_006524775.1  N-acetylmuramoyl-L-alanine amidase isoform X1

    See identical proteins and their annotated locations for XP_006524775.1

    Conserved Domains (1) summary
    smart00701
    Location:360505
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
  4. XM_006524711.4XP_006524774.1  N-acetylmuramoyl-L-alanine amidase isoform X1

    See identical proteins and their annotated locations for XP_006524774.1

    Conserved Domains (1) summary
    smart00701
    Location:360505
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
  5. XM_006524710.4XP_006524773.1  N-acetylmuramoyl-L-alanine amidase isoform X1

    See identical proteins and their annotated locations for XP_006524773.1

    Conserved Domains (1) summary
    smart00701
    Location:360505
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme