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IL19 interleukin 19 [ Homo sapiens (human) ]

Gene ID: 29949, updated on 4-Sep-2022

Summary

Official Symbol
IL19provided by HGNC
Official Full Name
interleukin 19provided by HGNC
Primary source
HGNC:HGNC:5990
See related
Ensembl:ENSG00000142224 MIM:605687; AllianceGenome:HGNC:5990
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDA1; NG.1; ZMDA1; IL-10C
Summary
The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See IL19 in Genome Data Viewer
Location:
1q32.1
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (206770773..206842981)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (206034974..206107261)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (206944118..207016326)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MAPK activated protein kinase 2 Neighboring gene ribosomal protein S14 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 3087 Neighboring gene interleukin 10 Neighboring gene uncharacterized LOC105372878 Neighboring gene uncharacterized LOC105372879 Neighboring gene interleukin 20

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
EBI GWAS Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat IL-19 is upregulated in human epithelial cells by HIV-1 Tat treatment PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
interleukin-19
Names
melanoma differentiation associated protein-like protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369605.1NP_001356534.1  interleukin-19 precursor

    Status: REVIEWED

    Source sequence(s)
    AF453946, AL513315, AY040367, CA309757
    UniProtKB/Swiss-Prot
    Q9NUA0
    Related
    ENSP00000343000.3, ENST00000340758.7
    Conserved Domains (1) summary
    cl02501
    Location:21167
    IL10; Interleukin 10
  2. NM_001393490.1NP_001380419.1  interleukin-19 precursor

    Status: REVIEWED

    Source sequence(s)
    AL513315
    UniProtKB/Swiss-Prot
    Q9NUA0
    Related
    ENSP00000499487.2, ENST00000656872.2
    Conserved Domains (1) summary
    cl02501
    Location:21167
    IL10; Interleukin 10
  3. NM_001393491.1NP_001380420.1  interleukin-19 precursor

    Status: REVIEWED

    Source sequence(s)
    AL513315
    UniProtKB/Swiss-Prot
    Q9NUA0
    Conserved Domains (1) summary
    cl02501
    Location:21167
    IL10; Interleukin 10
  4. NM_013371.5NP_037503.2  interleukin-19 precursor

    See identical proteins and their annotated locations for NP_037503.2

    Status: REVIEWED

    Source sequence(s)
    AL513315
    Consensus CDS
    CCDS1469.1
    UniProtKB/Swiss-Prot
    Q9NUA0, Q9UHD0
    Related
    ENSP00000270218.6, ENST00000270218.10
    Conserved Domains (1) summary
    cl02501
    Location:21167
    IL10; Interleukin 10
  5. NM_153758.5NP_715639.2  interleukin-19 precursor

    Status: REVIEWED

    Source sequence(s)
    AL513315
    Consensus CDS
    CCDS1468.1
    UniProtKB/Swiss-Prot
    Q9NUA0
    Related
    ENSP00000499459.2, ENST00000659997.3
    Conserved Domains (1) summary
    cl02501
    Location:21167
    IL10; Interleukin 10

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    206770773..206842981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509450.3XP_011507752.1  interleukin-19 isoform X1

    See identical proteins and their annotated locations for XP_011507752.1

    UniProtKB/Swiss-Prot
    Q9UHD0

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    206034974..206107261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)