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GPR132 G protein-coupled receptor 132 [ Homo sapiens (human) ]

Gene ID: 29933, updated on 15-Apr-2019

Summary

Official Symbol
GPR132provided by HGNC
Official Full Name
G protein-coupled receptor 132provided by HGNC
Primary source
HGNC:HGNC:17482
See related
Ensembl:ENSG00000183484 MIM:606167
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G2A
Summary
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein was reported to be a receptor for lysophosphatidylcholine action, but PubMedID: 15653487 retracts this finding and instead suggests this protein to be an effector of lysophosphatidylcholine action. This protein may have proton-sensing activity and may be a receptor for oxidized free fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Broad expression in appendix (RPKM 4.0), lymph node (RPKM 3.6) and 20 other tissues See more
Orthologs

Genomic context

See GPR132 in Genome Data Viewer
Location:
14q32.33
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (105049389..105065550, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (105515726..105531887, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene clathrin binding box of aftiphilin containing 1 Neighboring gene cell division cycle associated 4 Neighboring gene long intergenic non-protein coding RNA 2298 Neighboring gene jagged canonical Notch ligand 2 Neighboring gene microRNA 6765

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

General gene information

Markers

Potential readthrough

Included gene: CDCA4

Homology

Clone Names

  • MGC99642

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
probable G-protein coupled receptor 132
Names
G2 accumulation protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278694.1NP_001265623.1  probable G-protein coupled receptor 132 isoform 1

    See identical proteins and their annotated locations for NP_001265623.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA714520, AK292142, BC084546, W15172
    Consensus CDS
    CCDS9997.1
    UniProtKB/Swiss-Prot
    Q9UNW8
    Related
    ENSP00000438094.2, ENST00000539291.6
    Conserved Domains (1) summary
    cd15364
    Location:43319
    7tmA_GPR132_G2A; proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001278695.1NP_001265624.1  probable G-protein coupled receptor 132 isoform 2

    See identical proteins and their annotated locations for NP_001265624.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct and shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA714520, AB465600, W15172
    Consensus CDS
    CCDS61567.1
    UniProtKB/Swiss-Prot
    Q9UNW8
    Related
    ENSP00000376364.2, ENST00000392585.2
    Conserved Domains (1) summary
    pfam00001
    Location:85299
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. NM_001278696.1NP_001265625.1  probable G-protein coupled receptor 132 isoform 3

    See identical proteins and their annotated locations for NP_001265625.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region and uses a downstream, in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA714520, BC084546, DB137292, W15172
    UniProtKB/Swiss-Prot
    Q9UNW8
    Conserved Domains (1) summary
    pfam00001
    Location:16120
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  4. NM_013345.4NP_037477.1  probable G-protein coupled receptor 132 isoform 1

    See identical proteins and their annotated locations for NP_037477.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA714520, AB465599
    Consensus CDS
    CCDS9997.1
    UniProtKB/Swiss-Prot
    Q9UNW8
    Related
    ENSP00000328818.3, ENST00000329797.8
    Conserved Domains (1) summary
    cd15364
    Location:43319
    7tmA_GPR132_G2A; proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    105049389..105065550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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