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CDCA4 cell division cycle associated 4 [ Homo sapiens (human) ]

Gene ID: 55038, updated on 25-Nov-2021

Summary

Official Symbol
CDCA4provided by HGNC
Official Full Name
cell division cycle associated 4provided by HGNC
Primary source
HGNC:HGNC:14625
See related
Ensembl:ENSG00000170779 MIM:612270
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEPP; SEI-3/HEPP
Summary
This gene encodes a protein that belongs to the E2F family of transcription factors. This protein regulates E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein pathway. It also functions in the regulation of JUN oncogene expression. This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1. [provided by RefSeq, May 2014]
Expression
Broad expression in bone marrow (RPKM 19.7), placenta (RPKM 6.5) and 19 other tissues See more
Orthologs
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Genomic context

See CDCA4 in Genome Data Viewer
Location:
14q32.33
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (105009573..105021083, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (105475910..105487420, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene phospholipase D family member 4 Neighboring gene AHNAK nucleoprotein 2 Neighboring gene clathrin binding box of aftiphilin containing 1 Neighboring gene Sharpr-MPRA regulatory region 5751 Neighboring gene G protein-coupled receptor 132

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20764, FLJ52878, MGC19517

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
cell division cycle-associated protein 4
Names
hematopoietic progenitor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017955.4NP_060425.2  cell division cycle-associated protein 4

    See identical proteins and their annotated locations for NP_060425.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF322239, AL512802, BG354577, CN427719
    Consensus CDS
    CCDS9996.1
    UniProtKB/Swiss-Prot
    Q9BXL8
    UniProtKB/TrEMBL
    A0A024R6P3
    Related
    ENSP00000337226.3, ENST00000336219.4
    Conserved Domains (1) summary
    pfam06031
    Location:3773
    SERTA; SERTA motif
  2. NM_145701.4NP_663747.1  cell division cycle-associated protein 4

    See identical proteins and their annotated locations for NP_663747.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL512802, BC011736, BG354577, CN427719
    Consensus CDS
    CCDS9996.1
    UniProtKB/Swiss-Prot
    Q9BXL8
    UniProtKB/TrEMBL
    A0A024R6P3
    Related
    ENSP00000376369.3, ENST00000392590.3
    Conserved Domains (1) summary
    pfam06031
    Location:3773
    SERTA; SERTA motif

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    105009573..105021083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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