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PSMC3IP PSMC3 interacting protein [ Homo sapiens (human) ]

Gene ID: 29893, updated on 22-Aug-2021

Summary

Official Symbol
PSMC3IPprovided by HGNC
Official Full Name
PSMC3 interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:17928
See related
Ensembl:ENSG00000131470 MIM:608665
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOP2; ODG3; GT198; TBPIP; HUMGT198A
Summary
This gene encodes a protein that functions in meiotic recombination. It is a subunit of the PSMC3IP/MND1 complex, which interacts with PSMC3/TBP1 to stimulate DMC1- and RAD51-mediated strand exchange during meiosis. The protein encoded by this gene can also co-activate ligand-driven transcription mediated by estrogen, androgen, glucocorticoid, progesterone, and thyroid nuclear receptors. Mutations in this gene cause XX female gonadal dysgenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Expression
Ubiquitous expression in duodenum (RPKM 12.8), small intestine (RPKM 12.7) and 25 other tissues See more
Orthologs
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Genomic context

See PSMC3IP in Genome Data Viewer
Location:
17q21.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (42572310..42577831, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40724328..40729849, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene HSD17B1 promoter Neighboring gene HSD17B1 antisense RNA 1 Neighboring gene hydroxysteroid 17-beta dehydrogenase 1 Neighboring gene Coenzyme A synthase Neighboring gene MAX dimerization protein MLX Neighboring gene reticulophagy regulator family member 3 Neighboring gene tubulin gamma 1 Neighboring gene CRISPRi-validated cis-regulatory element chr17.2672

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat TBPIP is a cellular protein that interacts with Tat-binding protein-1 (TBP-1) and enhances the inhibitory action of TBP-1 on Tat-mediated transactivation of the HIV-1 LTR promoter PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear receptor coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables recombinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in homologous chromosome pairing at meiosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in meiotic joint molecule formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in meiotic strand invasion involved in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in reciprocal meiotic recombination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of DNA recombinase auxiliary factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in condensed nuclear chromosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
homologous-pairing protein 2 homolog
Names
DBD-interacting
TBP-1-interacting protein
nuclear receptor coactivator GT198
proteasome 26S ATPase subunit 3-interacting protein
tat-binding protein 1-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031960.1 RefSeqGene

    Range
    5001..10522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001256014.2NP_001242943.1  homologous-pairing protein 2 homolog isoform 3

    See identical proteins and their annotated locations for NP_001242943.1

    Status: REVIEWED

    Source sequence(s)
    AC067852
    Consensus CDS
    CCDS59289.1
    UniProtKB/Swiss-Prot
    Q9P2W1
    UniProtKB/TrEMBL
    K7ERB6
    Related
    ENSP00000468188.1, ENST00000587209.5
    Conserved Domains (1) summary
    pfam07106
    Location:1118
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
  2. NM_001256015.2NP_001242944.1  homologous-pairing protein 2 homolog isoform 4

    See identical proteins and their annotated locations for NP_001242944.1

    Status: REVIEWED

    Source sequence(s)
    AC067852
    UniProtKB/Swiss-Prot
    Q9P2W1
    Conserved Domains (1) summary
    pfam07106
    Location:1102
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
  3. NM_001256016.2NP_001242945.1  homologous-pairing protein 2 homolog isoform 4

    See identical proteins and their annotated locations for NP_001242945.1

    Status: REVIEWED

    Source sequence(s)
    AC067852
    UniProtKB/Swiss-Prot
    Q9P2W1
    Conserved Domains (1) summary
    pfam07106
    Location:1102
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
  4. NM_013290.7NP_037422.2  homologous-pairing protein 2 homolog isoform 1

    See identical proteins and their annotated locations for NP_037422.2

    Status: REVIEWED

    Source sequence(s)
    AC067852
    Consensus CDS
    CCDS11431.1
    UniProtKB/Swiss-Prot
    Q9P2W1
    Related
    ENSP00000253789.4, ENST00000253789.9
    Conserved Domains (1) summary
    pfam07106
    Location:16169
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
  5. NM_016556.4NP_057640.1  homologous-pairing protein 2 homolog isoform 2

    See identical proteins and their annotated locations for NP_057640.1

    Status: REVIEWED

    Source sequence(s)
    AC067852
    Consensus CDS
    CCDS45688.1
    UniProtKB/Swiss-Prot
    Q9P2W1
    UniProtKB/TrEMBL
    A0A158RUX1
    Related
    ENSP00000377384.2, ENST00000393795.8
    Conserved Domains (1) summary
    pfam07106
    Location:16181
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)

RNA

  1. NR_045669.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    BC008792, BQ186038, FJ952181
  2. NR_045670.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    BC008792, BQ186038, FJ952183
  3. NR_045671.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC067852

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    42572310..42577831 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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