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Psmc3ip proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein [ Mus musculus (house mouse) ]

Gene ID: 19183, updated on 8-Feb-2024

Summary

Official Symbol
Psmc3ipprovided by MGI
Official Full Name
proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting proteinprovided by MGI
Primary source
MGI:MGI:1098610
See related
Ensembl:ENSMUSG00000019303 AllianceGenome:MGI:1098610
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HOP2; GT198; Tbpip
Summary
Predicted to enable several functions, including DNA binding domain binding activity; nuclear receptor binding activity; and nuclear receptor coactivator activity. Predicted to be involved in meiosis I and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within DNA recombination and meiotic cell cycle. Predicted to be located in nucleoplasm. Predicted to be part of DNA recombinase auxiliary factor complex. Predicted to be active in condensed nuclear chromosome. Is expressed in metanephros; submandibular gland primordium; telencephalon ventricular layer; tooth; and vibrissa. Human ortholog(s) of this gene implicated in ovarian dysgenesis 3. Orthologous to human PSMC3IP (PSMC3 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 36.1), CNS E11.5 (RPKM 17.1) and 11 other tissues See more
Orthologs
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Genomic context

See Psmc3ip in Genome Data Viewer
Location:
11 D; 11 64.19 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100981238..100986261, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101092141..101095435, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene hydroxysteroid (17-beta) dehydrogenase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100943626-100943809 Neighboring gene STARR-positive B cell enhancer ABC_E7065 Neighboring gene Coenzyme A synthase Neighboring gene MAX-like protein X Neighboring gene STARR-positive B cell enhancer ABC_E11773 Neighboring gene reticulophagy regulator family member 3 Neighboring gene STARR-positive B cell enhancer ABC_E4001 Neighboring gene STARR-positive B cell enhancer ABC_E1843 Neighboring gene tubulin, gamma 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding domain binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear androgen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear glucocorticoid receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables recombinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
 
involved_in homologous chromosome pairing at meiosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in homologous chromosome pairing at meiosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in meiotic joint molecule formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in meiotic strand invasion involved in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in reciprocal meiotic recombination ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of DNA recombinase auxiliary factor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in condensed nuclear chromosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
homologous-pairing protein 2 homolog
Names
PSMC3-interacting protein
TBP-1-interacting protein
proteasome 26S ATPase subunit 3-interacting protein
tat-binding protein 1-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008949.3NP_032975.1  homologous-pairing protein 2 homolog

    See identical proteins and their annotated locations for NP_032975.1

    Status: VALIDATED

    Source sequence(s)
    AK133462, BF658859, BX255926
    Consensus CDS
    CCDS25448.1
    UniProtKB/Swiss-Prot
    O35047, Q3V035
    UniProtKB/TrEMBL
    C4PFH5
    Related
    ENSMUSP00000019447.9, ENSMUST00000019447.15
    Conserved Domains (1) summary
    pfam07106
    Location:16179
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100981238..100986261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245675.2XP_030101535.1  homologous-pairing protein 2 homolog isoform X1

    UniProtKB/TrEMBL
    C4PFH6
    Conserved Domains (1) summary
    pfam18517
    Location:45100
    LZ3wCH; Leucine zipper with capping helix domain
  2. XM_006532524.4XP_006532587.1  homologous-pairing protein 2 homolog isoform X1

    See identical proteins and their annotated locations for XP_006532587.1

    UniProtKB/TrEMBL
    C4PFH6
    Conserved Domains (1) summary
    pfam18517
    Location:45100
    LZ3wCH; Leucine zipper with capping helix domain