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GUCA2A guanylate cyclase activator 2A [ Homo sapiens (human) ]

Gene ID: 2980, updated on 7-Jun-2020

Summary

Official Symbol
GUCA2Aprovided by HGNC
Official Full Name
guanylate cyclase activator 2Aprovided by HGNC
Primary source
HGNC:HGNC:4682
See related
Ensembl:ENSG00000197273 MIM:139392
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GUCA2; STARA; GCAP-I
Expression
Biased expression in small intestine (RPKM 352.1), colon (RPKM 198.7) and 1 other tissue See more
Orthologs

Genomic context

See GUCA2A in Genome Data Viewer
Location:
1p34.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (42162690..42164745, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (42628362..42630395, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein F pseudogene 1 Neighboring gene guanylate cyclase activator 2B Neighboring gene forkhead box J3 Neighboring gene ribosomal modification protein rimK like family member A Neighboring gene ribosomal protein S15a pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with GUCA2A as demonstrated by proximity dependent biotinylation proteomics PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
guanylate cyclase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
guanylate cyclase activator activity NAS
Non-traceable Author Statement
more info
PubMed 
hormone activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
digestion TAS
Traceable Author Statement
more info
 
positive regulation of guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
guanylin
Names
guanylate cyclase activator 2A (guanylin 2, intestinal, heat-stable)
guanylate cyclase-activating protein 1
guanylate cyclase-activating protein I
prepro-guanylin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033553.3NP_291031.2  guanylin precursor

    See identical proteins and their annotated locations for NP_291031.2

    Status: VALIDATED

    Source sequence(s)
    AC114492, M97496, T28160
    Consensus CDS
    CCDS465.1
    UniProtKB/Swiss-Prot
    Q02747
    Related
    ENSP00000349493.2, ENST00000357001.3
    Conserved Domains (1) summary
    pfam02058
    Location:22115
    Guanylin; Guanylin precursor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    42162690..42164745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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