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Guca2a guanylate cyclase activator 2a (guanylin) [ Mus musculus (house mouse) ]

Gene ID: 14915, updated on 26-Jun-2024

Summary

Official Symbol
Guca2aprovided by MGI
Official Full Name
guanylate cyclase activator 2a (guanylin)provided by MGI
Primary source
MGI:MGI:102738
See related
Ensembl:ENSMUSG00000023247 AllianceGenome:MGI:102738
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Guca2
Summary
Predicted to enable guanylate cyclase activator activity. Predicted to be located in extracellular region. Is expressed in several structures, including Meckel's cartilage; axial skeleton; esophagus; ganglia; and lower urinary tract. Orthologous to human GUCA2A (guanylate cyclase activator 2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 1725.5), large intestine adult (RPKM 563.5) and 2 other tissues See more
Orthologs
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Genomic context

See Guca2a in Genome Data Viewer
Location:
4 D2.1; 4 55.47 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (119494929..119496662)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (119637732..119639465)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene FSHD region gene 2 family member 1 Neighboring gene forkhead box J3 Neighboring gene STARR-seq mESC enhancer starr_11236 Neighboring gene STARR-seq mESC enhancer starr_11239 Neighboring gene guanylate cyclase activator 2b (retina) Neighboring gene predicted gene, 35761

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

General protein information

Preferred Names
guanylin
Names
guanylate cyclase activator 2 (guanylin 2, intestinal, heatstable)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008190.1NP_032216.1  guanylin precursor

    See identical proteins and their annotated locations for NP_032216.1

    Status: PROVISIONAL

    Source sequence(s)
    M95175
    Consensus CDS
    CCDS18586.1
    UniProtKB/Swiss-Prot
    P33680
    Related
    ENSMUSP00000024015.3, ENSMUST00000024015.3
    Conserved Domains (1) summary
    pfam02058
    Location:22116
    Guanylin; Guanylin precursor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    119494929..119496662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)