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GTF3C2 general transcription factor IIIC subunit 2 [ Homo sapiens (human) ]

Gene ID: 2976, updated on 9-Sep-2025
Official Symbol
GTF3C2provided by HGNC
Official Full Name
general transcription factor IIIC subunit 2provided by HGNC
Primary source
HGNC:HGNC:4665
See related
Ensembl:ENSG00000115207 MIM:604883; AllianceGenome:HGNC:4665
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TF3C-beta; TFIIIC110; TFIIIC-BETA
Summary
Enables RNA polymerase III general transcription initiation factor activity. Contributes to DNA binding activity. Involved in transcription by RNA polymerase III. Located in nucleoplasm. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in thyroid (RPKM 13.6), skin (RPKM 10.5) and 25 other tissues See more
Orthologs
mouse all
NEW
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See GTF3C2 in Genome Data Viewer
Location:
2p23.3
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (27325854..27356764, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (27368277..27401404, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27548721..27579631, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 54 Neighboring gene mitochondrial inner membrane protein MPV17 Neighboring gene urocortin Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27543343-27543946 Neighboring gene Sharpr-MPRA regulatory regions 9483 and 12628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15498 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27545801-27546773 Neighboring gene GTF3C2 antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr2:27579025-27579638 and GRCh37_chr2:27579639-27580252 Neighboring gene GTF3C2 antisense RNA 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27582391-27583132 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27592451-27593412 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27593413-27594374 Neighboring gene eukaryotic translation initiation factor 2B subunit delta Neighboring gene sorting nexin 17 Neighboring gene zinc finger protein 513

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. A test of the model that RNA polymerase III transcription is regulated by selective induction of the 110 kDa subunit of TFIIIC. Innes F, et al. Nucleic Acids Res, 2006. PMID 16822860, Free PMC Article
  2. Human transcription factors IIIC2 , IIIC1 and a novel component IIIC0 fulfil different aspects of DNA binding to various pol III genes. Oettel S, et al. Nucleic Acids Res, 1997 Jun 15. PMID 9171097, Free PMC Article
  3. DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III. Wang Z, et al. Mol Cell, 1998 Apr. PMID 9660958
  4. RNA polymerase III transcription repressed by Rb through its interactions with TFIIIB and TFIIIC2. Chu WM, et al. J Biol Chem, 1997 Jun 6. PMID 9169441
  5. Different functional modes of p300 in activation of RNA polymerase III transcription from chromatin templates. Mertens C, et al. Mol Cell Biol, 2008 Sep. PMID 18644873, Free PMC Article

See all (108) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The transcription factor Sp1 modulates RNA polymerase III gene transcription by controlling BRF1 and GTF3C2 expression in human cells.
    Title: The transcription factor Sp1 modulates RNA polymerase III gene transcription by controlling BRF1 and GTF3C2 expression in human cells.
  2. Evidence against the model that pol III transcription can be effectively modulated through the specific induction of TFIIIC110.
    Title: A test of the model that RNA polymerase III transcription is regulated by selective induction of the 110 kDa subunit of TFIIIC.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0011

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase III general transcription initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 5S class rRNA transcription by RNA polymerase III IC
Inferred by Curator
more info
 PubMed 
involved_in tRNA transcription by RNA polymerase III IC
Inferred by Curator
more info
 PubMed 
involved_in transcription by RNA polymerase III IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIIC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIIC complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
general transcription factor 3C polypeptide 2
Names
TFIIIC 110 kDa subunit
general transcription factor IIIC, polypeptide 2, beta 110kDa
transcription factor IIIC 110 kDa subunit
transcription factor IIIC subunit beta

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035521.3 → NP_001030598.1  general transcription factor 3C polypeptide 2 isoform b

    See identical proteins and their annotated locations for NP_001030598.1

    Status: VALIDATED

    Source sequence(s)
    BC020981, D13636, DB286393
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    D6W557, Q16632, Q8WUA4, Q9BWI7
    Related
    ENSP00000264720.3, ENST00000264720.8
    Conserved Domains (3) summary
    PTZ00449
    Location:62 → 255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558 → 595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559 → 644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001318909.4 → NP_001305838.2  general transcription factor 3C polypeptide 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    D6W557, Q16632, Q8WUA4, Q9BWI7
    Related
    ENSP00000352536.2, ENST00000359541.6
    Conserved Domains (3) summary
    PTZ00449
    Location:62 → 255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558 → 595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559 → 644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_001388380.3 → NP_001375309.2  general transcription factor 3C polypeptide 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    D6W557, Q16632, Q8WUA4, Q9BWI7
    Related
    ENSP00000542660.1, ENST00000872601.1
    Conserved Domains (3) summary
    PTZ00449
    Location:62 → 255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558 → 595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559 → 644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. NM_001394503.1 → NP_001381432.1  general transcription factor 3C polypeptide 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    D6W557, Q16632, Q8WUA4, Q9BWI7
    Related
    ENSP00000542655.1, ENST00000872596.1
    Conserved Domains (3) summary
    PTZ00449
    Location:62 → 255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558 → 595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559 → 644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. NM_001394504.1 → NP_001381433.1  general transcription factor 3C polypeptide 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    D6W557, Q16632, Q8WUA4, Q9BWI7
    Conserved Domains (3) summary
    PTZ00449
    Location:62 → 255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558 → 595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559 → 644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. NM_001394505.1 → NP_001381434.1  general transcription factor 3C polypeptide 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    D6W557, Q16632, Q8WUA4, Q9BWI7
    Conserved Domains (3) summary
    PTZ00449
    Location:62 → 255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558 → 595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559 → 644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  7. NM_001394506.1 → NP_001381435.1  general transcription factor 3C polypeptide 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    D6W557, Q16632, Q8WUA4, Q9BWI7
    Conserved Domains (3) summary
    PTZ00449
    Location:62 → 255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558 → 595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559 → 644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  8. NM_001394507.1 → NP_001381436.1  general transcription factor 3C polypeptide 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    D6W557, Q16632, Q8WUA4, Q9BWI7
    Related
    ENSP00000582178.1, ENST00000912119.1
    Conserved Domains (3) summary
    PTZ00449
    Location:62 → 255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558 → 595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559 → 644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  9. NM_001394508.1 → NP_001381437.1  general transcription factor 3C polypeptide 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    D6W557, Q16632, Q8WUA4, Q9BWI7
    Related
    ENSP00000542661.1, ENST00000872602.1
    Conserved Domains (3) summary
    PTZ00449
    Location:62 → 255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558 → 595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559 → 644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  10. NM_001394509.1 → NP_001381438.1  general transcription factor 3C polypeptide 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    D6W557, Q16632, Q8WUA4, Q9BWI7
    Conserved Domains (3) summary
    PTZ00449
    Location:62 → 255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558 → 595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559 → 644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  11. NM_001394510.1 → NP_001381439.1  general transcription factor 3C polypeptide 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    D6W557, Q16632, Q8WUA4, Q9BWI7
    Related
    ENSP00000542664.1, ENST00000872605.1
    Conserved Domains (3) summary
    PTZ00449
    Location:62 → 255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558 → 595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559 → 644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  12. NM_001394511.1 → NP_001381440.1  general transcription factor 3C polypeptide 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    D6W557, Q16632, Q8WUA4, Q9BWI7
    Related
    ENSP00000542658.1, ENST00000872599.1
    Conserved Domains (3) summary
    PTZ00449
    Location:62 → 255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558 → 595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559 → 644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  13. NM_001394512.1 → NP_001381441.1  general transcription factor 3C polypeptide 2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Related
    ENSP00000582180.1, ENST00000912121.1
    Conserved Domains (3) summary
    PTZ00449
    Location:62 → 255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:554 → 591
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:555 → 640
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  14. NM_001394514.1 → NP_001381443.1  general transcription factor 3C polypeptide 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Related
    ENSP00000582182.1, ENST00000912123.1
    Conserved Domains (3) summary
    PTZ00449
    Location:62 → 255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:532 → 569
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:533 → 618
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  15. NM_001394515.1 → NP_001381444.1  general transcription factor 3C polypeptide 2 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Conserved Domains (3) summary
    PTZ00449
    Location:62 → 255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00320
    Location:553 → 590
    WD40; WD40 repeats
    sd00039
    Location:564 → 604
    7WD40; WD40 repeat [structural motif]

  16. NM_001394516.1 → NP_001381445.1  general transcription factor 3C polypeptide 2 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Related
    ENSP00000542659.1, ENST00000872600.1
    Conserved Domains (3) summary
    PTZ00449
    Location:62 → 255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:482 → 519
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:483 → 568
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  17. NM_001521.4 → NP_001512.1  general transcription factor 3C polypeptide 2 isoform b

    See identical proteins and their annotated locations for NP_001512.1

    Status: VALIDATED

    Source sequence(s)
    BC020981, D13636, DA399212
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    D6W557, Q16632, Q8WUA4, Q9BWI7
    Related
    ENSP00000542656.1, ENST00000872597.1
    Conserved Domains (3) summary
    PTZ00449
    Location:62 → 255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558 → 595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559 → 644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    27325854..27356764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444016.1 → XP_047299972.1  general transcription factor 3C polypeptide 2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    27368277..27401404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341540.1 → XP_054197515.1  general transcription factor 3C polypeptide 2 isoform X4

    UniProtKB/Swiss-Prot
    D6W557, Q16632, Q8WUA4, Q9BWI7

  2. XM_054341539.1 → XP_054197514.1  general transcription factor 3C polypeptide 2 isoform X4

    UniProtKB/Swiss-Prot
    D6W557, Q16632, Q8WUA4, Q9BWI7

  3. XM_054341537.1 → XP_054197512.1  general transcription factor 3C polypeptide 2 isoform X2

  4. XM_054341538.1 → XP_054197513.1  general transcription factor 3C polypeptide 2 isoform X3

  5. XM_054341536.1 → XP_054197511.1  general transcription factor 3C polypeptide 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WUA4.2 GenPept UniProtKB/Swiss-Prot:Q8WUA4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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