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GTF3C2 general transcription factor IIIC subunit 2 [ Homo sapiens (human) ]

Gene ID: 2976, updated on 4-Dec-2022

Summary

Official Symbol
GTF3C2provided by HGNC
Official Full Name
general transcription factor IIIC subunit 2provided by HGNC
Primary source
HGNC:HGNC:4665
See related
Ensembl:ENSG00000115207 MIM:604883; AllianceGenome:HGNC:4665
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TF3C-beta; TFIIIC110; TFIIIC-BETA
Summary
Contributes to DNA binding activity. Involved in transcription by RNA polymerase III. Located in nucleoplasm. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 13.6), skin (RPKM 10.5) and 25 other tissues See more
Orthologs
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Genomic context

See GTF3C2 in Genome Data Viewer
Location:
2p23.3
Exon count:
22
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (27325854..27356764, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (27368277..27399147, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27548721..27579631, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 54 Neighboring gene mitochondrial inner membrane protein MPV17 Neighboring gene urocortin Neighboring gene Sharpr-MPRA regulatory regions 9483 and 12628 Neighboring gene GTF3C2 antisense RNA 1 Neighboring gene GTF3C2 antisense RNA 2 Neighboring gene eukaryotic translation initiation factor 2B subunit delta Neighboring gene sorting nexin 17 Neighboring gene zinc finger protein 513

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0011

General protein information

Preferred Names
general transcription factor 3C polypeptide 2
Names
TFIIIC 110 kDa subunit
general transcription factor IIIC, polypeptide 2, beta 110kDa
transcription factor IIIC 110 kDa subunit
transcription factor IIIC subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035521.3NP_001030598.1  general transcription factor 3C polypeptide 2 isoform b

    See identical proteins and their annotated locations for NP_001030598.1

    Status: VALIDATED

    Source sequence(s)
    BC020981, D13636, DB286393
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    Q8WUA4, Q9BWI7
    Related
    ENSP00000264720.3, ENST00000264720.8
    Conserved Domains (3) summary
    PTZ00449
    Location:62255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001318909.4NP_001305838.2  general transcription factor 3C polypeptide 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    Q9BWI7
    Related
    ENSP00000352536.2, ENST00000359541.6
    Conserved Domains (3) summary
    PTZ00449
    Location:62255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001388380.3NP_001375309.2  general transcription factor 3C polypeptide 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    Q9BWI7
    Conserved Domains (3) summary
    PTZ00449
    Location:62255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_001394503.1NP_001381432.1  general transcription factor 3C polypeptide 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    Q9BWI7
    Conserved Domains (3) summary
    PTZ00449
    Location:62255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. NM_001394504.1NP_001381433.1  general transcription factor 3C polypeptide 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    Q9BWI7
    Conserved Domains (3) summary
    PTZ00449
    Location:62255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. NM_001394505.1NP_001381434.1  general transcription factor 3C polypeptide 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    Q9BWI7
    Conserved Domains (3) summary
    PTZ00449
    Location:62255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. NM_001394506.1NP_001381435.1  general transcription factor 3C polypeptide 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    Q9BWI7
    Conserved Domains (3) summary
    PTZ00449
    Location:62255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  8. NM_001394507.1NP_001381436.1  general transcription factor 3C polypeptide 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    Q9BWI7
    Conserved Domains (3) summary
    PTZ00449
    Location:62255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  9. NM_001394508.1NP_001381437.1  general transcription factor 3C polypeptide 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    Q9BWI7
    Conserved Domains (3) summary
    PTZ00449
    Location:62255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  10. NM_001394509.1NP_001381438.1  general transcription factor 3C polypeptide 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    Q9BWI7
    Conserved Domains (3) summary
    PTZ00449
    Location:62255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  11. NM_001394510.1NP_001381439.1  general transcription factor 3C polypeptide 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    Q9BWI7
    Conserved Domains (3) summary
    PTZ00449
    Location:62255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  12. NM_001394511.1NP_001381440.1  general transcription factor 3C polypeptide 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    Q9BWI7
    Conserved Domains (3) summary
    PTZ00449
    Location:62255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  13. NM_001394512.1NP_001381441.1  general transcription factor 3C polypeptide 2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Conserved Domains (3) summary
    PTZ00449
    Location:62255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:554591
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:555640
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  14. NM_001394514.1NP_001381443.1  general transcription factor 3C polypeptide 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Conserved Domains (3) summary
    PTZ00449
    Location:62255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:532569
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:533618
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  15. NM_001394515.1NP_001381444.1  general transcription factor 3C polypeptide 2 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Conserved Domains (3) summary
    PTZ00449
    Location:62255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00320
    Location:553590
    WD40; WD40 repeats
    sd00039
    Location:564604
    7WD40; WD40 repeat [structural motif]
  16. NM_001394516.1NP_001381445.1  general transcription factor 3C polypeptide 2 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC013413, AC074117, AC109828
    Conserved Domains (3) summary
    PTZ00449
    Location:62255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:482519
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:483568
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  17. NM_001521.4NP_001512.1  general transcription factor 3C polypeptide 2 isoform b

    See identical proteins and their annotated locations for NP_001512.1

    Status: VALIDATED

    Source sequence(s)
    BC020981, D13636, DA399212
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    Q8WUA4, Q9BWI7
    Conserved Domains (3) summary
    PTZ00449
    Location:62255
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00039
    Location:558595
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:559644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    27325854..27356764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444016.1XP_047299972.1  general transcription factor 3C polypeptide 2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    27368277..27399147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)