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GTF3C2 general transcription factor IIIC subunit 2 [ Homo sapiens (human) ]

Gene ID: 2976, updated on 4-Oct-2020

Summary

Official Symbol
GTF3C2provided by HGNC
Official Full Name
general transcription factor IIIC subunit 2provided by HGNC
Primary source
HGNC:HGNC:4665
See related
Ensembl:ENSG00000115207 MIM:604883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TFIIIC110; TFIIIC-BETA
Expression
Ubiquitous expression in thyroid (RPKM 13.6), skin (RPKM 10.5) and 25 other tissues See more
Orthologs

Genomic context

See GTF3C2 in Genome Data Viewer
Location:
2p23.3
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (27325851..27357376, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27548716..27580243, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 54 Neighboring gene mitochondrial inner membrane protein MPV17 Neighboring gene urocortin Neighboring gene Sharpr-MPRA regulatory regions 9483 and 12628 Neighboring gene GTF3C2 antisense RNA 1 Neighboring gene uncharacterized LOC105374363 Neighboring gene eukaryotic translation initiation factor 2B subunit delta Neighboring gene sorting nexin 17 Neighboring gene zinc finger protein 513

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0011

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
transcription factor TFIIIC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor TFIIIC complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
general transcription factor 3C polypeptide 2
Names
TF3C-beta
TFIIIC 110 kDa subunit
general transcription factor IIIC, polypeptide 2, beta 110kDa
transcription factor IIIC 110 kDa subunit
transcription factor IIIC subunit beta

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035521.3NP_001030598.1  general transcription factor 3C polypeptide 2 isoform b

    See identical proteins and their annotated locations for NP_001030598.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1 and 2 both encode the same isoform (b).
    Source sequence(s)
    BC020981, D13636, DB286393
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    Q8WUA4
    Related
    ENSP00000264720.3, ENST00000264720.7
    Conserved Domains (3) summary
    sd00039
    Location:558595
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:559644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl25751
    Location:62255
    DUF4045; Domain of unknown function (DUF4045)
  2. NM_001318909.2NP_001305838.1  general transcription factor 3C polypeptide 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC013413, AC109828, BC020981, BX647092
    UniProtKB/Swiss-Prot
    Q8WUA4
    Conserved Domains (3) summary
    COG2319
    Location:569734
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:569606
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:570655
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001521.4NP_001512.1  general transcription factor 3C polypeptide 2 isoform b

    See identical proteins and their annotated locations for NP_001512.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1 and 2 both encode the same isoform (b).
    Source sequence(s)
    BC020981, D13636, DA399212
    Consensus CDS
    CCDS1749.1
    UniProtKB/Swiss-Prot
    Q8WUA4
    Conserved Domains (3) summary
    sd00039
    Location:558595
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:559644
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl25751
    Location:62255
    DUF4045; Domain of unknown function (DUF4045)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    27325851..27357376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264272.5XP_005264329.1  general transcription factor 3C polypeptide 2 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:597762
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:597634
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:598683
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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