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Kcnab2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29738, updated on 6-Jun-2024

Summary

Official Symbol
Kcnab2provided by RGD
Official Full Name
potassium voltage-gated channel subfamily A regulatory beta subunit 2provided by RGD
Primary source
RGD:61828
See related
Ensembl:ENSRNOG00000011550 AllianceGenome:RGD:61828
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables aldo-keto reductase (NADP) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in several processes, including NADPH oxidation; myoblast differentiation; and regulation of protein localization to cell surface. Located in cytosol; juxtaparanode region of axon; and pinceau fiber. Is extrinsic component of cytoplasmic side of plasma membrane. Part of potassium channel complex. Colocalizes with microtubule. Orthologous to human KCNAB2 (potassium voltage-gated channel subfamily A regulatory beta subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 249.8), Thymus (RPKM 121.4) and 3 other tissues See more
Orthologs
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Genomic context

See Kcnab2 in Genome Data Viewer
Location:
5q36
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (168182228..168270760, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (162899511..162988057, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (169570327..169658875, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103139 Neighboring gene ribosomal protein L22 Neighboring gene chromodomain helicase DNA binding protein 5 Neighboring gene small ribosomal subunit protein eS27-like Neighboring gene nephrocystin 4 Neighboring gene uncharacterized LOC134479049 Neighboring gene uncharacterized LOC102549399

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aldo-keto reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables aldo-keto reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables potassium channel regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables potassium channel regulator activity IEA
Inferred from Electronic Annotation
more info
 
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IEA
Inferred from Electronic Annotation
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in axon initial segment ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in juxtaparanode region of axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in juxtaparanode region of axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in juxtaparanode region of axon IEA
Inferred from Electronic Annotation
more info
 
located_in juxtaparanode region of axon ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in pinceau fiber IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated potassium channel complex IEA
Inferred from Electronic Annotation
more info
 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
voltage-gated potassium channel subunit beta-2
Names
K(+) channel subunit beta-2
kv-beta-2
potassium channel, voltage gated shaker-related subfamily A regulatory beta subunit 2
potassium channel, voltage gated subfamily A regulatory beta subunit 2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
NP_059000.1
XP_017448703.1
XP_017448704.1
XP_038965314.1
XP_063143337.1
XP_063143338.1
XP_063143339.1
XP_063143340.1
XP_063143341.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429742.1NP_001416671.1  voltage-gated potassium channel subunit beta-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A0G2K670
  2. NM_001429743.1NP_001416672.1  voltage-gated potassium channel subunit beta-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A0G2K670
  3. NM_001429744.1NP_001416673.1  voltage-gated potassium channel subunit beta-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I5ZVX6, A0A8L2Q7L3
  4. NM_001429745.1NP_001416674.1  voltage-gated potassium channel subunit beta-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I5ZVX6
  5. NM_001429746.1NP_001416675.1  voltage-gated potassium channel subunit beta-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P62483
    UniProtKB/TrEMBL
    A0A8I5ZVX6, A6IUI6
  6. NM_001429747.1NP_001416676.1  voltage-gated potassium channel subunit beta-2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I5ZVX6, A0A8I6GCY0
  7. NM_001429748.1NP_001416677.1  voltage-gated potassium channel subunit beta-2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I5ZVX6, A0A8I6GCY0
  8. NM_017304.3NP_059000.1  voltage-gated potassium channel subunit beta-2 isoform 5

    See identical proteins and their annotated locations for NP_059000.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P62483
    UniProtKB/TrEMBL
    A0A8I5ZVX6, A6IUI6
    Conserved Domains (1) summary
    cd19141
    Location:38347
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    168182228..168270760 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017593214.3XP_017448703.1  voltage-gated potassium channel subunit beta-2 isoform X1

    Related
    ENSRNOP00000015840.3
    Conserved Domains (1) summary
    cd19141
    Location:38363
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
  2. XM_039109386.2XP_038965314.1  voltage-gated potassium channel subunit beta-2 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZVX6
    Conserved Domains (1) summary
    cl00470
    Location:1296
    AKR_SF; Aldo-keto reductase (AKR) superfamily
  3. XM_063287270.1XP_063143340.1  voltage-gated potassium channel subunit beta-2 isoform X5

  4. XM_063287268.1XP_063143338.1  voltage-gated potassium channel subunit beta-2 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZVX6
  5. XM_063287269.1XP_063143339.1  voltage-gated potassium channel subunit beta-2 isoform X4

  6. XM_063287267.1XP_063143337.1  voltage-gated potassium channel subunit beta-2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZVX6
  7. XM_017593215.3XP_017448704.1  voltage-gated potassium channel subunit beta-2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZVX6, A0A8L2Q7L3
    Conserved Domains (1) summary
    cd19141
    Location:38363
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
  8. XM_063287271.1XP_063143341.1  voltage-gated potassium channel subunit beta-2 isoform X7