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Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 [ Mus musculus (house mouse) ]

Gene ID: 16498, updated on 7-Apr-2025

Summary

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Official Symbol
Kcnab2provided by MGI
Official Full Name
potassium voltage-gated channel, shaker-related subfamily, beta member 2provided by MGI
Primary source
MGI:MGI:109239
See related
Ensembl:ENSMUSG00000028931 AllianceGenome:MGI:109239
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
F5; I2rf5; Kcnb3; kv-beta-2
Summary
Predicted to enable aldo-keto reductase (NADPH) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in neuromuscular process. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in axon terminus; juxtaparanode region of axon; and postsynaptic density. Is active in axon initial segment. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; intestine; and sensory organ. Used to study chromosome 1p36 deletion syndrome. Orthologous to human KCNAB2 (potassium voltage-gated channel subfamily A regulatory beta subunit 2). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in cortex adult (RPKM 40.8), frontal lobe adult (RPKM 32.0) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Kcnab2 in Genome Data Viewer
Location:
4 E2; 4 83.08 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (152475201..152561991, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (152390744..152477549, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9430083M05 gene Neighboring gene STARR-positive B cell enhancer ABC_E846 Neighboring gene ribosomal protein L22 Neighboring gene chromodomain helicase DNA binding protein 5 Neighboring gene predicted gene 16333 Neighboring gene nephronophthisis 4 (juvenile) homolog (human) Neighboring gene predicted gene, 30734 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of the T-lymphocyte activation gene, F5, by mature neurons. Arai M, et al. J Neurosci Res, 1992 Dec. PMID 1484386
  2. Characterization of a novel mRNA expressed by neurons in mature brain. Cohen JA, et al. J Neurosci Res, 1992 Feb. PMID 1573677
  3. Deletion of the mouse homolog of KCNAB2, a gene linked to monosomy 1p36, results in associative memory impairments and amygdala hyperexcitability. Perkowski JJ, et al. J Neurosci, 2011 Jan 5. PMID 21209188, Free PMC Article
  4. The potassium channel auxiliary subunit Kvβ2 (Kcnab2) regulates Kv1 channels and dopamine neuron firing. Yee JX, et al. J Neurophysiol, 2022 Jul 1. PMID 35788155, Free PMC Article
  5. Physiological role of Kvβ2 (AKR6) in murine skeletal muscle growth and regulation. Chapalamadugu KC, et al. Acta Physiol (Oxf), 2018 Oct. PMID 29704886, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The potassium channel auxiliary subunit Kvbeta2 (Kcnab2) regulates Kv1 channels and dopamine neuron firing.
    Title: The potassium channel auxiliary subunit Kvβ2 (Kcnab2) regulates Kv1 channels and dopamine neuron firing.
  2. Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvbeta Proteins.
    Title: Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvβ Proteins.
  3. Kvbeta2 subunits regulate the expression of myocardial Kv channels and confer redox sensitivity to Kv current and cardiac repolarization.
    Title: Metabolic regulation of Kv channels and cardiac repolarization by Kvβ2 subunits.
  4. Genetic deletion of Kvbeta2 leads to decreased skeletal muscle size along with isotype switching from fast to slow fiber type.
    Title: Physiological role of Kvβ2 (AKR6) in murine skeletal muscle growth and regulation.
  5. Article reports a newly identified protein-protein interaction between the postsynaptic density-protein ProSAP2/Shank3 and the voltage-gated potassium channel subunit Kvbeta2
    Title: The Kvβ2 subunit of voltage-gated potassium channels is interacting with ProSAP2/Shank3 in the PSD.
  6. the association of a Kvbeta subunit with TRPV1 channels, is reported.
    Title: Identification of voltage-gated K(+) channel beta 2 (Kvβ2) subunit as a novel interaction partner of the pain transducer Transient Receptor Potential Vanilloid 1 channel (TRPV1).
  7. This study demonistrated that loss of Kvbeta2 likely contributes to the cognitive and neurological impairments observed in 1p36DS patients.
    Title: Deletion of the mouse homolog of KCNAB2, a gene linked to monosomy 1p36, results in associative memory impairments and amygdala hyperexcitability.
  8. strain differences significantly affected survival, body weight and thermoregulation in Kv beta2-null mice
    Title: Genetic modifiers of the Kv beta2-null phenotype in mice.
  9. investigation of in vivo function
    Title: Genetic analysis of the mammalian K+ channel beta subunit Kvbeta 2 (Kcnab2).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aldo-keto reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldo-keto reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables aldo-keto reductase (NADPH) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables methylglyoxal reductase (NADPH) (acetol producing) activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuromuscular process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization to cell surface ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
  
is_active_in axon initial segment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon terminus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in juxtaparanode region of axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in juxtaparanode region of axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in juxtaparanode region of axon ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
  
located_in pinceau fiber ISO
Inferred from Sequence Orthology
more info
  
located_in pinceau fiber ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  
part_of potassium channel complex ISO
Inferred from Sequence Orthology
more info
  
part_of potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
voltage-gated potassium channel subunit beta-2
Names
K(+) channel subunit beta-2
neuroimmune protein F5
NP_001239583.1
NP_001239584.1
NP_001239585.1
NP_001342101.1
NP_001342102.1
NP_001408146.1
NP_001408147.1
NP_001408148.1
NP_001408150.1
NP_001408151.1
NP_001408152.1
NP_001408153.1
NP_001408154.1
NP_034728.2
XP_006538647.1
XP_006538648.1
XP_006538649.1
XP_006538650.1
XP_011248501.1
XP_030109127.1
XP_036019635.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252654.3 → NP_001239583.1  voltage-gated potassium channel subunit beta-2 isoform 2

    See identical proteins and their annotated locations for NP_001239583.1

    Status: VALIDATED

    Source sequence(s)
    AL611985
    Consensus CDS
    CCDS57316.1
    UniProtKB/TrEMBL
    Q3U0B0, Q3UPV6
    Related
    ENSMUSP00000030768.3, ENSMUST00000030768.10
    Conserved Domains (1) summary
    cd19141
    Location:25 → 333
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

  2. NM_001252655.3 → NP_001239584.1  voltage-gated potassium channel subunit beta-2 isoform 2

    See identical proteins and their annotated locations for NP_001239584.1

    Status: VALIDATED

    Source sequence(s)
    AL611985
    Consensus CDS
    CCDS57316.1
    UniProtKB/TrEMBL
    Q3U0B0, Q3UPV6
    Related
    ENSMUSP00000124156.3, ENSMUST00000159840.8
    Conserved Domains (1) summary
    cd19141
    Location:25 → 333
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

  3. NM_001252656.3 → NP_001239585.1  voltage-gated potassium channel subunit beta-2 isoform 1

    See identical proteins and their annotated locations for NP_001239585.1

    Status: VALIDATED

    Source sequence(s)
    AL611985
    Consensus CDS
    CCDS19000.1
    UniProtKB/Swiss-Prot
    P62482, P97381, Q60942, Q64284
    UniProtKB/TrEMBL
    Q3U0B0
    Related
    ENSMUSP00000101273.3, ENSMUST00000105648.10
    Conserved Domains (1) summary
    cd19141
    Location:38 → 347
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

  4. NM_001355172.2 → NP_001342101.1  voltage-gated potassium channel subunit beta-2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 5 encode the same isoform (1).
    Source sequence(s)
    AL611985
    Consensus CDS
    CCDS19000.1
    UniProtKB/Swiss-Prot
    P62482, P97381, Q60942, Q64284
    UniProtKB/TrEMBL
    Q3U0B0
    Conserved Domains (1) summary
    cd19141
    Location:38 → 347
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

  5. NM_001355173.2 → NP_001342102.1  voltage-gated potassium channel subunit beta-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL611985
    UniProtKB/TrEMBL
    Q3U0B0
    Related
    ENSMUSP00000158843.2, ENSMUST00000238738.2
    Conserved Domains (1) summary
    cd19141
    Location:38 → 363
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

  6. NM_001421217.1 → NP_001408146.1  voltage-gated potassium channel subunit beta-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL611985
    UniProtKB/Swiss-Prot
    P62482, P97381, Q60942, Q64284
    UniProtKB/TrEMBL
    Q3U0B0

  7. NM_001421218.1 → NP_001408147.1  voltage-gated potassium channel subunit beta-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL611985
    UniProtKB/TrEMBL
    Q3U0B0

  8. NM_001421219.1 → NP_001408148.1  voltage-gated potassium channel subunit beta-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL611985
    UniProtKB/TrEMBL
    A0A571BEM7
    Related
    ENSMUSP00000158839.2, ENSMUST00000238715.2

  9. NM_001421221.1 → NP_001408150.1  voltage-gated potassium channel subunit beta-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL611985
    UniProtKB/TrEMBL
    A0A571BEM7

  10. NM_001421222.1 → NP_001408151.1  voltage-gated potassium channel subunit beta-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL611985
    UniProtKB/TrEMBL
    A0A571BEM7

  11. NM_001421223.1 → NP_001408152.1  voltage-gated potassium channel subunit beta-2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL611985
    UniProtKB/TrEMBL
    A0A571BF54, Q3U0B0
    Related
    ENSMUSP00000158771.2, ENSMUST00000238252.2

  12. NM_001421224.1 → NP_001408153.1  voltage-gated potassium channel subunit beta-2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL611985
    UniProtKB/TrEMBL
    A0A571BEM7

  13. NM_001421225.1 → NP_001408154.1  voltage-gated potassium channel subunit beta-2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL611985
    UniProtKB/TrEMBL
    E0CXZ9, Q3U0B0
    Related
    ENSMUSP00000124588.3, ENSMUST00000159186.9

  14. NM_010598.5 → NP_034728.2  voltage-gated potassium channel subunit beta-2 isoform 1

    See identical proteins and their annotated locations for NP_034728.2

    Status: VALIDATED

    Source sequence(s)
    AL611985
    Consensus CDS
    CCDS19000.1
    UniProtKB/Swiss-Prot
    P62482, P97381, Q60942, Q64284
    UniProtKB/TrEMBL
    Q3U0B0
    Related
    ENSMUSP00000125058.2, ENSMUST00000160884.9
    Conserved Domains (1) summary
    cd19141
    Location:38 → 347
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    152475201..152561991 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250199.3 → XP_011248501.1  voltage-gated potassium channel subunit beta-2 isoform X3

    See identical proteins and their annotated locations for XP_011248501.1

    UniProtKB/TrEMBL
    Q3U0B0
    Conserved Domains (1) summary
    cd19141
    Location:38 → 363
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

  2. XM_006538586.4 → XP_006538649.1  voltage-gated potassium channel subunit beta-2 isoform X4

    See identical proteins and their annotated locations for XP_006538649.1

    UniProtKB/TrEMBL
    Q3U0B0
    Conserved Domains (1) summary
    cd19141
    Location:25 → 349
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

  3. XM_030253267.1 → XP_030109127.1  voltage-gated potassium channel subunit beta-2 isoform X5

    UniProtKB/Swiss-Prot
    P62482, P97381, Q60942, Q64284
    UniProtKB/TrEMBL
    Q3U0B0
    Conserved Domains (1) summary
    cd19141
    Location:38 → 347
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

  4. XM_006538585.4 → XP_006538648.1  voltage-gated potassium channel subunit beta-2 isoform X3

    See identical proteins and their annotated locations for XP_006538648.1

    UniProtKB/TrEMBL
    Q3U0B0
    Conserved Domains (1) summary
    cd19141
    Location:38 → 363
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

  5. XM_006538584.5 → XP_006538647.1  voltage-gated potassium channel subunit beta-2 isoform X3

    See identical proteins and their annotated locations for XP_006538647.1

    UniProtKB/TrEMBL
    Q3U0B0
    Conserved Domains (1) summary
    cd19141
    Location:38 → 363
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

  6. XM_006538587.5 → XP_006538650.1  voltage-gated potassium channel subunit beta-2 isoform X4

    See identical proteins and their annotated locations for XP_006538650.1

    UniProtKB/TrEMBL
    Q3U0B0
    Conserved Domains (1) summary
    cd19141
    Location:25 → 349
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

  7. XM_036163742.1 → XP_036019635.1  voltage-gated potassium channel subunit beta-2 isoform X3

    UniProtKB/TrEMBL
    Q3U0B0
    Conserved Domains (1) summary
    cd19141
    Location:38 → 363
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62482.1 GenPept UniProtKB/Swiss-Prot:P62482

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