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GTF2B general transcription factor IIB [ Homo sapiens (human) ]

Gene ID: 2959, updated on 21-Apr-2019

Summary

Official Symbol
GTF2Bprovided by HGNC
Official Full Name
general transcription factor IIBprovided by HGNC
Primary source
HGNC:HGNC:4648
See related
Ensembl:ENSG00000137947 MIM:189963
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TF2B; TFIIB
Summary
This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 18.5), gall bladder (RPKM 11.2) and 25 other tissues See more
Orthologs

Genomic context

See GTF2B in Genome Data Viewer
Location:
1p22.2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (88852638..88891944, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (89318321..89357301, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene protein kinase N2 Neighboring gene RNA, U6 small nuclear 125, pseudogene Neighboring gene elongin C pseudogene 19 Neighboring gene shieldin complex subunit 1 pseudogene Neighboring gene kynurenine aminotransferase 3 Neighboring gene RBMX like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Binding of HIV-1 Tat to p300 induces a conformational change in the CBP/p300 complex such that it can acquire and bind better to transcription factors such as TBP and TFIIB, indicating Tat helps CBP/p300 recruit new partners to the transcription machinery PubMed
tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme complex that supports Tat-mediated transactivation of the HIV-1 LTR in vitro upon addition of TBP and TFIIB PubMed
tat HIV-1 Tat interacts with a cellular protein, TAP (Tat-associated protein), that functions as a co-activator and bridges Tat to the general transcription machinery via TFIIB PubMed
tat HIV-1 Tat directly interacts with TFIIB as demonstrated by Tat-affinity column purification PubMed
tat Transactivation of the HIV-1 LTR by HIV-1 Tat and the cellular cofactor Tat-SF1 is mediated by basal transcription factors, including TFIIB PubMed
tat Overexpression of TFIIB inhibits HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter PubMed
tat The cysteine rich and core domains (amino acids 27-103) of HIV-1 Tat mediate binding to two domains of TFIIB, amino acids 27-103 in the N-terminal domain and the first direct repeat of the C-terminal domain between amino acids 148-163 PubMed
Vpr vpr Specific binding of HIV-1 Vpr (amino acids 15-35) to TFIIB (amino acids 52-55) causes a conformational change in TFIIB and is correlated with the ability of Vpr to stimulate transcription through the glucocorticoid receptor pathway PubMed
nucleocapsid gag HIV-1 Nucleocapsid has been shown to bind to the HIV-1 LTR promoter and enhance NF-kappaB, Sp1, and TFIIB-induced HIV-1 LTR-directed RNA transcription PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II complex binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II general transcription initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
TBP-class protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
core promoter binding IDA
Inferred from Direct Assay
more info
PubMed 
histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thyroid hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA polymerase II core complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA polymerase II preinitiation complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II preinitiation complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone acetylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation by host of viral transcription IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of core promoter binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription initiation from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of viral transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein acetylation IDA
Inferred from Direct Assay
more info
PubMed 
snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
transcription initiation from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcriptional start site selection at RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
RNA polymerase II transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II transcription factor complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromosome IDA
Inferred from Direct Assay
more info
PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-DNA complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
PubMed 
transcriptional preinitiation complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription initiation factor IIB
Names
RNA polymerase II transcription factor IIB
S300-II
general transcription factor TFIIB
NP_001505.1
XP_011539601.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001514.6NP_001505.1  transcription initiation factor IIB

    See identical proteins and their annotated locations for NP_001505.1

    Status: REVIEWED

    Source sequence(s)
    AL445991
    Consensus CDS
    CCDS715.1
    UniProtKB/Swiss-Prot
    Q00403
    Related
    ENSP00000359531.5, ENST00000370500.10
    Conserved Domains (1) summary
    COG1405
    Location:14290
    SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    88852638..88891944 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541299.1XP_011539601.1  transcription initiation factor IIB isoform X1

    See identical proteins and their annotated locations for XP_011539601.1

    Conserved Domains (1) summary
    COG1405
    Location:2259
    SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]

RNA

  1. XR_001737129.1 RNA Sequence

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