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Gtf2b general transcription factor IIB [ Mus musculus (house mouse) ]

Gene ID: 229906, updated on 9-Mar-2023

Summary

Official Symbol
Gtf2bprovided by MGI
Official Full Name
general transcription factor IIBprovided by MGI
Primary source
MGI:MGI:2385191
See related
Ensembl:ENSMUSG00000028271 AllianceGenome:MGI:2385191
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables DNA binding activity and promoter-specific chromatin binding activity. Predicted to be involved in several processes, including RNA polymerase II core complex assembly; positive regulation of core promoter binding activity; and transcription initiation from RNA polymerase II promoter. Located in nucleus. Is expressed in cerebral cortex; pancreas; and testis. Orthologous to human GTF2B (general transcription factor IIB). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 50.6), liver E18 (RPKM 42.4) and 28 other tissues See more
Orthologs
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Genomic context

See Gtf2b in Genome Data Viewer
Location:
3; 3 H1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (142471008..142489367)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (142765247..142783606)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene human immunodeficiency virus type I enhancer binding protein 1 pseudogene Neighboring gene kynurenine aminotransferase 3 Neighboring gene predicted gene, 24457 Neighboring gene predicted gene, 25965 Neighboring gene protein kinase N2 Neighboring gene RIKEN cDNA 9530052C20 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC6859

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II complex binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II core promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
enables TBP-class protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
 
enables acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA-templated transcription initiation IEA
Inferred from Electronic Annotation
more info
 
involved_in RNA polymerase II core complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in RNA polymerase II core complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in RNA polymerase II preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in chromosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryo development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of core promoter binding ISO
Inferred from Sequence Orthology
more info
 
involved_in protein acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transcription initiation at RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
involved_in transcription preinitiation complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in transcriptional start site selection at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transcriptional start site selection at RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
involved_in viral transcription ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell division site IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in condensed chromosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in germinal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription initiation factor IIB
Names
RNA polymerase II alpha initiation factor
general transcription factor TFIIB
NP_663521.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145546.1NP_663521.1  transcription initiation factor IIB

    See identical proteins and their annotated locations for NP_663521.1

    Status: PROVISIONAL

    Source sequence(s)
    BC016637
    Consensus CDS
    CCDS17882.1
    UniProtKB/Swiss-Prot
    P29053, P62915
    UniProtKB/TrEMBL
    A0A6P5PG10, A0A8C6GVW6, Q3ULN2
    Related
    ENSMUSP00000029938.9, ENSMUST00000029938.10
    Conserved Domains (1) summary
    COG1405
    Location:14290
    SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    142471008..142489367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)