Dkk2 dickkopf WNT signaling pathway inhibitor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dkk2provided by RGD
Official Full Name: dickkopf WNT signaling pathway inhibitor 2provided by RGD
Primary source: RGD:1308639
See related: EnsemblRapid:ENSRNOG00000011360 AllianceGenome:RGD:1308639
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable co-receptor binding activity and receptor antagonist activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway and positive regulation of canonical Wnt signaling pathway. Predicted to be active in extracellular space. Orthologous to human DKK2 (dickkopf WNT signaling pathway inhibitor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 126.6), Muscle (RPKM 51.1) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q43

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (223242375..223334249)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (220568338..220660225)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (237148918..237240883)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-128 promotes osteogenic differentiation of bone marrow mesenchymal stem cells in rat by targeting DKK2.
Title: MiR-128 promotes osteogenic differentiation of bone marrow mesenchymal stem cells in rat by targeting DKK2.
there are distinct functions of DKK1 and DKK2 in controlling angiogenesis
Title: The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells.

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General gene information

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Markers

RH139355 (e-PCR)
- UniSTS:221441

AI071994 (e-PCR)
- UniSTS:244490

Dkk2 (e-PCR), detects polymorphism
- UniSTS:471822

Dkk2 (e-PCR), detects polymorphism
- UniSTS:472902

AU049557 (e-PCR)
- UniSTS:146004

Dkk2 (e-PCR), detects polymorphism
- UniSTS:277878

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables co-receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables co-receptor binding	ISO Inferred from Sequence Orthology more info
enables receptor antagonist activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dickkopf-related protein 2

Names: dickkopf 2 homolog; dickkopf homolog 2; dickkopf homolog 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.