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Dkk2 dickkopf WNT signaling pathway inhibitor 2 [ Mus musculus (house mouse) ]

Gene ID: 56811, updated on 17-Jan-2023

Summary

Official Symbol
Dkk2provided by MGI
Official Full Name
dickkopf WNT signaling pathway inhibitor 2provided by MGI
Primary source
MGI:MGI:1890663
See related
Ensembl:ENSMUSG00000028031 AllianceGenome:MGI:1890663
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables co-receptor binding activity. Involved in negative regulation of Wnt signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; eye; and genitourinary system. Orthologous to human DKK2 (dickkopf WNT signaling pathway inhibitor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 20.3), bladder adult (RPKM 10.5) and 5 other tissues See more
Orthologs
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Genomic context

See Dkk2 in Genome Data Viewer
Location:
3; 3 G3
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (131791027..131886065)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (132085266..132180304)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29949 Neighboring gene predicted gene, 22421 Neighboring gene predicted gene, 30147 Neighboring gene GIMAP family P-loop NTPase domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables co-receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables co-receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dickkopf-related protein 2
Names
dickkopf 2
dickkopf homolog 1
dickkopf homolog 2
dkk-2
mDkk-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020265.4NP_064661.2  dickkopf-related protein 2 precursor

    See identical proteins and their annotated locations for NP_064661.2

    Status: VALIDATED

    Source sequence(s)
    AC127260
    Consensus CDS
    CCDS17844.1
    UniProtKB/Swiss-Prot
    Q8BFW0, Q9QYZ8
    UniProtKB/TrEMBL
    A0A8C6IJ94
    Related
    ENSMUSP00000029665.6, ENSMUST00000029665.7
    Conserved Domains (1) summary
    pfam04706
    Location:78128
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    131791027..131886065
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501818.5XP_006501881.1  dickkopf-related protein 2 isoform X1

    Conserved Domains (1) summary
    pfam04706
    Location:91141
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region