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DKK2 dickkopf WNT signaling pathway inhibitor 2 [ Homo sapiens (human) ]

Gene ID: 27123, updated on 5-Aug-2022

Summary

Official Symbol
DKK2provided by HGNC
Official Full Name
dickkopf WNT signaling pathway inhibitor 2provided by HGNC
Primary source
HGNC:HGNC:2892
See related
Ensembl:ENSG00000155011 MIM:605415; AllianceGenome:HGNC:2892
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DKK-2
Summary
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]
Expression
Broad expression in lung (RPKM 4.8), ovary (RPKM 3.0) and 14 other tissues See more
Orthologs
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Genomic context

See DKK2 in Genome Data Viewer
Location:
4q25
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (106921802..107036313, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (110226876..110341391, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (107842959..107957470, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377356 Neighboring gene ACTR6 pseudogene 1 Neighboring gene vomeronasal 1 receptor 22 pseudogene Neighboring gene vomeronasal 1 receptor 23 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables co-receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dickkopf-related protein 2
Names
dickkopf 2 homolog
dickkopf homolog 2
dickkopf-2
hDkk-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014421.3NP_055236.1  dickkopf-related protein 2 precursor

    See identical proteins and their annotated locations for NP_055236.1

    Status: REVIEWED

    Source sequence(s)
    AF177395, AP001819, AY358414
    Consensus CDS
    CCDS3675.1
    UniProtKB/Swiss-Prot
    Q9UBU2, Q9UIU3
    Related
    ENSP00000285311.3, ENST00000285311.8
    Conserved Domains (1) summary
    pfam04706
    Location:78128
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    106921802..107036313 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    110226876..110341391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)